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HAMAP rule MF_00709

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General rule information [?]

Accession MF_00709
Dates 9-SEP-2003 (Created)
15-MAY-2020 (Last updated, Version 27)
Name Fumarate_red_D
Scope
Bacteria; Gammaproteobacteria
Bacteria; Mycobacterium
Template P0A8Q3 (FRDD_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FRDD
case <OC:Enterobacterales>
Protein name
RecName: Full=Fumarate reductase subunit D;
AltName: Full=Fumarate reductase 13 kDa hydrophobic protein;
AltName: Full=Quinol-fumarate reductase subunit D;
Short=QFR subunit D;
else
Protein name
RecName: Full=Fumarate reductase subunit D;
AltName: Full=Quinol-fumarate reductase subunit D;
Short=QFR subunit D;
end case
Gene name
frdD

Comments [?]

case <OC:Enterobacterales>
Function Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
else
Function Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
end case
Subunit Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the FrdD family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005886; Cellular component: plasma membrane.
GO:0045284; Cellular component: plasma membrane fumarate reductase complex.
GO:0000104; Molecular function: succinate dehydrogenase activity.

Cross-references [?]

Pfam PF02313; Fumarate_red_D; 1;

Computed features [?]

General Transmembrane; -; 3; trigger=yes;

Additional information [?]

Size range 114-130 amino acids
Related rules None
Fusion None


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