HAMAP rule MF_00713

General rule information [?]

Accession	MF_00713
Dates	1-OCT-2003 (Created) 3-FEB-2022 (Last updated, Version 22)
Name	GcvPB
Scope(s)	Bacteria Archaea
Template(s)	P54377 (GCSPB_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_00713 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GCSPB
Protein name	RecName: Full=Probable glycine dehydrogenase (decarboxylating) subunit 2; EC=1.4.4.2; AltName: Full=Glycine cleavage system P-protein subunit 2; AltName: Full=Glycine decarboxylase subunit 2; AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 2;
Gene name	Name=gcvPB;

Comments [?]

FUNCTION	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
CATALYTIC ACTIVITY	Reaction=(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl- [glycine-cleavage complex H protein] + CO2; Xref=Rhea:RHEA:24304, Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099, ChEBI:CHEBI:83143; EC=1.4.4.2;
COFACTOR	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
SUBUNIT	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.
SIMILARITY	Belongs to the GcvP family. C-terminal subunit subfamily.

Keywords [?]

Gene Ontology [?]

GO:0019464; Biological process:glycine decarboxylation via glycine cleavage system

Cross-references [?]

Pfam	PF02347; GDC-P; 1;

Features [?]

From: GCSPB_BACSU (P54377)

Key

From

Description

Tag

Condition

FTGroup

MOD_RES

273

/note="N6-(pyridoxal phosphate)lysine"

Additional information [?]