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Annotation rule MF_00719
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General rule information [?]

Accession MF_00719
Dates 10-OCT-2003 (Created)
18-NOV-2019 (Last updated, Version 36)
Name CobS
Scope
Bacteria
Archaea
Templates P36561 (COBS_ECOLI); P29936 (COBV_SINSX); Q05602 (COBS_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COBS
Protein name
RecName: Full=Adenosylcobinamide-GDP ribazoletransferase;
EC 2.7.8.26;
AltName: Full=Cobalamin-5'-phosphate synthase;
AltName: Full=Cobalamin synthase;
Gene name
cobS

Comments [?]

Function Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Catalytic activity RHEA:16049: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)
EC 2.7.8.26
RHEA:23560: adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
EC 2.7.8.26
Cofactor Mg(2+)
Pathway Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the CobS family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Cobalamin biosynthesis
Magnesium
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008818; Molecular function: cobalamin 5'-phosphate synthase activity.
GO:0051073; Molecular function: adenosylcobinamide-GDP ribazoletransferase activity.
GO:0009236; Biological process: cobalamin biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02654; CobS; 1;
PRINTS PR01036; TCRTETB; 1;
TIGRFAMs TIGR00317; CobS; 1;

Computed features [?]

General Transmembrane; -; 4-8; trigger=yes;

Additional information [?]

Size range 199-307 amino acids
Related rules None
Fusion None


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