HAMAP rule MF_00719
General rule information
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Accession | MF_00719 |
Dates | 10-OCT-2003 (Created) 1-JUN-2023 (Last updated, Version 37) |
Name | CobS |
Scope | Bacteria
Archaea |
Templates | P36561 (COBS_ECOLI); P29936 (COBV_SINSX); Q05602 (COBS_SALTY): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate. |
Catalytic activity | RHEA:16049: adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)
EC 2.7.8.26 |
RHEA:23560: adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
EC 2.7.8.26 |
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Cofactor | Mg(2+) |
Pathway | Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the CobS family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Cell membrane
Cobalamin biosynthesis
Magnesium
Membrane
Transferase
Transmembrane
Transmembrane helix
Cobalamin biosynthesis
Magnesium
Membrane
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0008818; Molecular function: cobalamin 5'-phosphate synthase activity.
GO:0051073; Molecular function: adenosylcobinamide-GDP ribazoletransferase activity.
GO:0009236; Biological process: cobalamin biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0051073; Molecular function: adenosylcobinamide-GDP ribazoletransferase activity.
GO:0009236; Biological process: cobalamin biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 4-8; trigger=yes; |
Additional information
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Size range | 199-307 amino acids |
Related rules | None |
Fusion | None |