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HAMAP rule MF_00719

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General rule information [?]

Accession MF_00719
Dates 10-OCT-2003 (Created)
1-JUN-2023 (Last updated, Version 37)
Name CobS
Scope(s) Bacteria
Template(s) P36561 (COBS_ECOLI); P29936 (COBV_SINSX); Q05602 (COBS_SALTY); [ Recover all ]
Triggered by HAMAP; MF_00719 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COBS
Protein name RecName: Full=Adenosylcobinamide-GDP ribazoletransferase;
AltName: Full=Cobalamin-5'-phosphate synthase;
AltName: Full=Cobalamin synthase;
Gene name Name=cobS;

Comments [?]

FUNCTIONJoins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate.
CATALYTIC ACTIVITY Reaction=adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+); Xref=Rhea:RHEA:16049, ChEBI:CHEBI:10329, ChEBI:CHEBI:15378, ChEBI:CHEBI:18408, ChEBI:CHEBI:58115, ChEBI:CHEBI:60487; EC=;
CATALYTIC ACTIVITY Reaction=adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+); Xref=Rhea:RHEA:23560, ChEBI:CHEBI:15378, ChEBI:CHEBI:57918, ChEBI:CHEBI:58115, ChEBI:CHEBI:60487, ChEBI:CHEBI:60493; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYCofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the CobS family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Cobalamin biosynthesis
Transmembrane helix

Gene Ontology [?]

GO:0008818; Molecular function:cobalamin 5'-phosphate synthase activity
GO:0051073; Molecular function:adenosylcobinamide-GDP ribazoletransferase activity
GO:0009236; Biological process:cobalamin biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02654; CobS; 1;
NCBIfam TIGR00317; CobS; 1;
General Transmembrane; -; 4-8;

Features [?]

Additional information [?]

Size range 199-307 amino acids
Related rules None
Fusion Nter: None Cter: None

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