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Annotation rule MF_00723 |
General rule information
[?]
Accession |
MF_00723 |
Dates |
1-NOV-2003 (Created) 18-NOV-2019 (Last updated, Version 27) |
Scope |
Bacteria; Proteobacteria |
case <OC:Bacteria>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Glutathione-dependent formaldehyde-activating enzyme;
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EC 4.4.1.22;
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AltName:
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Full=S-(hydroxymethyl)glutathione synthase;
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Function |
Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione. |
Catalytic activity |
RHEA:22488: S-(hydroxymethyl)glutathione = formaldehyde + glutathione
EC 4.4.1.22
|
case <FTGroup:1>
Cofactor |
Zn(2+) Note: Binds 2 Zn(2+) ions per subunit. |
end case
Pathway |
One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3. |
Similarity |
Belongs to the Gfa family. |
case <FTGroup:1>
end case
GO:0051907; Molecular function: S-(hydroxymethyl)glutathione synthase activity.
GO:0046294; Biological process: formaldehyde catabolic process.
case <FTGroup:1>
end case
From: GFA_PARDE (Q51669) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
|
METAL
|
|
31
|
|
31
|
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Zinc 1; structural
|
|
|
|
C
|
|
1
|
METAL
|
|
33
|
|
33
|
|
Zinc 1; structural
|
|
|
|
C
|
|
1
|
METAL
|
|
52
|
|
52
|
|
Zinc 2; catalytic
|
|
|
|
C
|
|
1
|
METAL
|
|
54
|
|
54
|
|
Zinc 2; catalytic
|
|
|
|
C
|
|
1
|
METAL
|
|
57
|
|
57
|
|
Zinc 2; catalytic
|
|
|
|
C
|
|
1
|
METAL
|
|
99
|
|
99
|
|
Zinc 1; structural
|
|
|
|
C
|
|
1
|
METAL
|
|
102
|
|
102
|
|
Zinc 1; structural
|
|
|
|
C
|
|
1
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Additional information
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Size range |
187-194 amino acids |
Related rules |
None |
Fusion |
None |