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Annotation rule MF_00723
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General rule information [?]

Accession MF_00723
Dates 1-NOV-2003 (Created)
18-NOV-2019 (Last updated, Version 27)
Name Formald_GSH
Scope
Bacteria; Proteobacteria
Template Q51669 (GFA_PARDE)
case <OC:Bacteria>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GFA
Protein name
RecName: Full=Glutathione-dependent formaldehyde-activating enzyme;
EC 4.4.1.22;
AltName: Full=S-(hydroxymethyl)glutathione synthase;
Gene name
gfa

Comments [?]

Function Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.
Catalytic activity RHEA:22488: S-(hydroxymethyl)glutathione = formaldehyde + glutathione
EC 4.4.1.22
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.
end case
Pathway One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.
Similarity Belongs to the Gfa family.

Keywords [?]

Lyase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0051907; Molecular function: S-(hydroxymethyl)glutathione synthase activity.
GO:0046294; Biological process: formaldehyde catabolic process.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF04828; GFA; 1;
PIRSF PIRSF033318; Formald_GSH; 1;
TIGRFAMs TIGR02820; Formald_GSH; 1;
PROSITE PS51891; CENP_V_GFA; 1; trigger=PRU01239;

Features [?]

From: GFA_PARDE (Q51669)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     31     31       Zinc 1; structural     C   1
METAL     33     33       Zinc 1; structural     C   1
METAL     52     52       Zinc 2; catalytic     C   1
METAL     54     54       Zinc 2; catalytic     C   1
METAL     57     57       Zinc 2; catalytic     C   1
METAL     99     99       Zinc 1; structural     C   1
METAL     102     102       Zinc 1; structural     C   1

Additional information [?]

Size range 187-194 amino acids
Related rules None
Fusion None


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