HAMAP rule MF_00725

General rule information [?]

Accession	MF_00725
Dates	5-NOV-2003 (Created) 26-JAN-2023 (Last updated, Version 26)

Name

FlhD

Scope

Bacteria; Pseudomonadota

Template

P0A8S9 (FLHD_ECOLI)

Triggered by

HAMAP; MF_00725 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FLHD

Protein name

RecName:

Full=Flagellar transcriptional regulator FlhD;

Gene name

flhD

Comments [?]

Function	Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Subunit	Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
Subcellular location	Cytoplasm.
Domain	The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.
Similarity	Belongs to the FlhD family.

Keywords [?]

Activator
Bacterial flagellum biogenesis
Cytoplasm

case <FT:1>

Disulfide bond

end case

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:1902208; Biological process: regulation of bacterial-type flagellum assembly.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF05247; FlhD; 1;

Features [?]

From: FLHD_ECOLI (P0A8S9)

Key From To Description Tag Condition FTGroup

DISULFID 65 65 Interchain C

Additional information [?]

Size range	85-127 amino acids
Related rules	None
Fusion	None

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