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HAMAP rule MF_00725

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General rule information [?]

Accession MF_00725
Dates 5-NOV-2003 (Created)
28-NOV-2023 (Last updated, Version 27)
Name FlhD
Scope(s) Bacteria
Template(s) P0A8S9 (FLHD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00725 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FLHD
Protein name RecName: Full=Flagellar transcriptional regulator FlhD;
Gene name Name=flhD;

Comments [?]

FUNCTIONFunctions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
SUBUNITHomodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
DOMAINThe C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.
SIMILARITYBelongs to the FlhD family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:1902208; Biological process:regulation of bacterial-type flagellum assembly
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF05247; FlhD; 1;

Features [?]

Key From To Description Tag Condition FTGroup
DISULFID 65 65 /note="Interchain" C

Additional information [?]

Size range 85-127 amino acids
Related rules None
Fusion Nter: None Cter: None

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