HAMAP rule MF_00725
General rule information
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Accession | MF_00725 |
Dates | 5-NOV-2003 (Created)
26-JAN-2023 (Last updated, Version 26) |
Name | FlhD |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0A8S9 (FLHD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00725 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | FLHD |
Protein name | RecName: Full=Flagellar transcriptional regulator FlhD; |
Gene name | Name=flhD; |
Comments
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FUNCTION | Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways. |
SUBUNIT | Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers. |
SUBCELLULAR LOCATION | Cytoplasm. |
DOMAIN | The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA. |
SIMILARITY | Belongs to the FlhD family. |
Keywords
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Activator | |
Bacterial flagellum biogenesis | |
Cytoplasm | |
case <FT:1> | |
Disulfide bond | |
end case | |
DNA-binding | |
Transcription | |
Transcription regulation |
Gene Ontology
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GO:0003677; Molecular function:DNA binding |
GO:0006355; Biological process:regulation of DNA-templated transcription |
GO:1902208; Biological process:regulation of bacterial-type flagellum assembly |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF05247; FlhD; 1; |
Features
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From: FLHD_ECOLI (P0A8S9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 65 | 65 | /note="Interchain" | C |
Additional information
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Size range | 85-127 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |