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HAMAP rule MF_00725

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General rule information [?]

Accession MF_00725
Dates 5-NOV-2003 (Created)
26-JAN-2023 (Last updated, Version 26)
Name FlhD
Bacteria; Pseudomonadota
Template P0A8S9 (FLHD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Flagellar transcriptional regulator FlhD;
Gene name

Comments [?]

Function Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Subunit Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
Subcellular location Cytoplasm.
Domain The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.
Similarity Belongs to the FlhD family.

Keywords [?]

case <FT:1>
end case

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:1902208; Biological process: regulation of bacterial-type flagellum assembly.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF05247; FlhD; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     65     65       Interchain     C  

Additional information [?]

Size range 85-127 amino acids
Related rules None
Fusion None