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HAMAP rule MF_00731

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General rule information [?]

Accession MF_00731
Dates 20-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 29)
Name MenE
Scope(s) Bacteria
Template(s) P23971 (MENE_BACSU); [ Recover all ]
Triggered by HAMAP; MF_00731 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MENE
Protein name RecName: Full=2-succinylbenzoate--CoA ligase;
AltName: Full=o-succinylbenzoyl-CoA synthetase;
                 Short=OSB-CoA synthetase;
Gene name Name=menE;

Comments [?]

FUNCTIONConverts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
CATALYTIC ACTIVITY Reaction=2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:17009, ChEBI:CHEBI:18325, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57364, ChEBI:CHEBI:456215; EC=;
PATHWAYQuinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7.
case not <OC:Cyanobacteriota>
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteriota>
PATHWAYCofactor biosynthesis; phylloquinone biosynthesis.
end case
SIMILARITYBelongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.

Keywords [?]

case not <OC:Cyanobacteriota>
Menaquinone biosynthesis
end case

Gene Ontology [?]

GO:0008756; Molecular function:o-succinylbenzoate-CoA ligase activity
case not <OCellular component:Cyanobacteriota>
GO:0009234; Biological process:menaquinone biosynthetic process
else case <OCellular component:Cyanobacteriota>
GO:0042372; Biological process:phylloquinone biosynthetic process
end case

Cross-references [?]

Pfam PF00501; AMP-binding; 1;
Pfam PF13193; AMP-binding_C; 1;
NCBIfam TIGR01923; MenE; 1;

Features [?]

Additional information [?]

Size range 438-514 amino acids
Related rules None
Fusion Nter: None Cter: None

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