HAMAP rule MF_00731
General rule information
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| Accession | MF_00731 |
| Dates | 20-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | MenE |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P23971 (MENE_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00731 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MENE |
| Protein name | RecName: Full=2-succinylbenzoate--CoA ligase; EC=6.2.1.26; AltName: Full=o-succinylbenzoyl-CoA synthetase; Short=OSB-CoA synthetase; |
| Gene name | Name=menE; |
Comments
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| FUNCTION | Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). |
| CATALYTIC ACTIVITY | Reaction=2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:17009, ChEBI:CHEBI:18325, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57364, ChEBI:CHEBI:456215; EC=6.2.1.26; |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7. |
| case not <OC:Cyanobacteriota> | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. |
Keywords
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| ATP-binding | |
| Ligase | |
| case not <OC:Cyanobacteriota> | |
| Menaquinone biosynthesis | |
| end case | |
| Nucleotide-binding | |
Gene Ontology
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| GO:0008756; Molecular function:o-succinylbenzoate-CoA ligase activity | |
| case not <OCellular component:Cyanobacteriota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0042372; Biological process:phylloquinone biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF00501; AMP-binding; 1; |
| Pfam | PF13193; AMP-binding_C; 1; |
| NCBIfam | TIGR01923; MenE; 1; |
| PROSITE | PS00455; AMP_BINDING; 1; |
Features
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Additional information
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| Size range | 438-514 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |