HAMAP rule MF_00731
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00731 |
| Accession | MF_00731 |
| Dates | 28-FEB-2005 (Created)
11-MAR-2026 (Last updated, Version ) |
| Name | MenE |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P23971; [ Recover all ] |
| Triggered by |
HAMAP; MF_00731 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MENE |
| Protein name | RecName: Full=2-succinylbenzoate--CoA ligase; EC=6.2.1.26; AltName: Full=o-succinylbenzoyl-CoA synthetase; Short=OSB-CoA synthetase; |
| Gene name | Name=menE; |
Comments
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| FUNCTION | Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). |
| CATALYTIC ACTIVITY | Reaction=2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:17009, ChEBI:CHEBI:18325, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57364, ChEBI:CHEBI:456215; EC=6.2.1.26; |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7. |
| case not <OC:Cyanobacteriota> | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
| end case | |
| SIMILARITY | Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. |
Keywords
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| ATP-binding | |
| Ligase | |
| case not <OC:Cyanobacteriota> | |
| Menaquinone biosynthesis | |
| end case | |
| Nucleotide-binding | |
Gene Ontology
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| GO:0008756; Molecular function:o-succinylbenzoate-CoA ligase activity | |
| case not <OCellular component:Cyanobacteriota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0042372; Biological process:phylloquinone biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF00501; AMP-binding; 1; |
| Pfam | PF13193; AMP-binding_C; 1; |
| NCBIfam | TIGR01923; menE; 1; |
| PROSITE | PS00455; AMP_BINDING; 1; |
Features
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| From: MENE_BACSU (P23971) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 152 | 152 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
| BINDING | 153 | 153 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
S | ||||||||
| BINDING | 154 | 154 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[GA] | ||||||||
| BINDING | 155 | 155 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS] | ||||||||
| BINDING | 156 | 156 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
| BINDING | 160 | 160 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 285 | 285 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[ST] | ||||||||
| BINDING | 289 | 289 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
T | ||||||||
| BINDING | 367 | 367 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
| BINDING | 382 | 382 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
Additional information
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| Size range | 438-514 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |