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HAMAP rule MF_00740

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General rule information [?]

Accession MF_00740
Dates 26-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 29)
Name Phosphopentomut
Scope(s) Bacteria
Template(s) P0A6K6 (DEOB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00740 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DEOB
Protein name RecName: Full=Phosphopentomutase;
AltName: Full=Phosphodeoxyribomutase;
Gene name Name=deoB;

Comments [?]

FUNCTIONPhosphotransfer between the C1 and C5 carbon atoms of pentose.
CATALYTIC ACTIVITY Reaction=alpha-D-ribose 1-phosphate = D-ribose 5-phosphate; Xref=Rhea:RHEA:18793, ChEBI:CHEBI:57720, ChEBI:CHEBI:78346; EC=;
CATALYTIC ACTIVITY Reaction=2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5- phosphate; Xref=Rhea:RHEA:27658, ChEBI:CHEBI:57259, ChEBI:CHEBI:62877;
PATHWAYMetabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 or 2 manganese ions.;
SIMILARITYBelongs to the phosphopentomutase family.

Keywords [?]

case <FT:6>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0030145; Molecular function:manganese ion binding
GO:0008973; Molecular function:phosphopentomutase activity
GO:0009264; Biological process:deoxyribonucleotide catabolic process
GO:0009166; Biological process:nucleotide catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01676; Metalloenzyme; 1;
NCBIfam TIGR01696; DeoB; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 10 10 /ligand="Mn(2+)"
D 1
BINDING 311 311 /ligand="Mn(2+)"
H 1
BINDING 347 347 /ligand="Mn(2+)"
D 1
BINDING 348 348 /ligand="Mn(2+)"
H 1
BINDING 359 359 /ligand="Mn(2+)"
H 1
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 287 287 /note="N6-acetyllysine" K
end case

Additional information [?]

Size range 388-418 amino acids
Related rules None
Fusion Nter: None Cter: None

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