HAMAP rule MF_00740
General rule information
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Accession | MF_00740 |
Dates | 26-NOV-2003 (Created)
24-JAN-2024 (Last updated, Version 30) |
Name | Phosphopentomut |
Scope(s) |
Bacteria |
Template(s) | P0A6K6 (DEOB_ECOLI); Q8DTU0 (DEOB_STRMU); [ Recover all ] |
Triggered by |
HAMAP; MF_00740 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DEOB |
Protein name | RecName: Full=Phosphopentomutase; EC=5.4.2.7; AltName: Full=Phosphodeoxyribomutase; |
Gene name | Name=deoB; |
Comments
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FUNCTION | Isomerase that catalyzes the conversion of deoxy-ribose 1- phosphate (dRib-1-P) and ribose 1-phosphate (Rib-1-P) to deoxy-ribose 5-phosphate (dRib-5-P) and ribose 5-phosphate (Rib-5-P), respectively. |
CATALYTIC ACTIVITY | Reaction=2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5- phosphate; Xref=Rhea:RHEA:27658, ChEBI:CHEBI:57259, ChEBI:CHEBI:62877; EC=5.4.2.7; |
CATALYTIC ACTIVITY | Reaction=alpha-D-ribose 1-phosphate = D-ribose 5-phosphate; Xref=Rhea:RHEA:18793, ChEBI:CHEBI:57720, ChEBI:CHEBI:78346; EC=5.4.2.7; |
case <FTGroup:1> and <FTGroup:2> | |
COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions.; |
else | |
COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
end case | |
PATHWAY | Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 1/2. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the phosphopentomutase family. |
Keywords
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Gene Ontology
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GO:0030145; Molecular function:manganese ion binding |
GO:0008973; Molecular function:phosphopentomutase activity |
GO:0006018; Biological process:2-deoxyribose 1-phosphate catabolic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF01676; Metalloenzyme; 1; |
NCBIfam | TIGR01696; deoB; 1; |
PIRSF | PIRSF001491; Ppentomutase; 1; |
Features
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From: DEOB_STRMU (Q8DTU0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 13 | 13 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | 1 | |||||||
BINDING | 298 | 298 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
D | 2 | |||||||
BINDING | 303 | 303 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
H | 2 | |||||||
BINDING | 339 | 339 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
D | 1 | |||||||
BINDING | 340 | 340 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1" |
H | 1 | |||||||
BINDING | 351 | 351 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2" |
H | 2 |
Additional information
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Size range | 388-418 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |