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HAMAP rule MF_00740

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General rule information [?]

Accession MF_00740
Dates 26-NOV-2003 (Created)
24-JAN-2024 (Last updated, Version 30)
Name Phosphopentomut
Scope(s) Bacteria
Template(s) P0A6K6 (DEOB_ECOLI); Q8DTU0 (DEOB_STRMU); [ Recover all ]
Triggered by HAMAP; MF_00740 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DEOB
Protein name RecName: Full=Phosphopentomutase;
AltName: Full=Phosphodeoxyribomutase;
Gene name Name=deoB;

Comments [?]

FUNCTIONIsomerase that catalyzes the conversion of deoxy-ribose 1- phosphate (dRib-1-P) and ribose 1-phosphate (Rib-1-P) to deoxy-ribose 5-phosphate (dRib-5-P) and ribose 5-phosphate (Rib-5-P), respectively.
CATALYTIC ACTIVITY Reaction=2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5- phosphate; Xref=Rhea:RHEA:27658, ChEBI:CHEBI:57259, ChEBI:CHEBI:62877; EC=;
CATALYTIC ACTIVITY Reaction=alpha-D-ribose 1-phosphate = D-ribose 5-phosphate; Xref=Rhea:RHEA:18793, ChEBI:CHEBI:57720, ChEBI:CHEBI:78346; EC=;
case <FTGroup:1> and <FTGroup:2>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions.;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
end case
PATHWAYCarbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 1/2.
SIMILARITYBelongs to the phosphopentomutase family.

Keywords [?]

Gene Ontology [?]

GO:0030145; Molecular function:manganese ion binding
GO:0008973; Molecular function:phosphopentomutase activity
GO:0006018; Biological process:2-deoxyribose 1-phosphate catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01676; Metalloenzyme; 1;
NCBIfam TIGR01696; deoB; 1;
PIRSF PIRSF001491; Ppentomutase; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 13 13 /ligand="Mn(2+)"
D 1
BINDING 298 298 /ligand="Mn(2+)"
D 2
BINDING 303 303 /ligand="Mn(2+)"
H 2
BINDING 339 339 /ligand="Mn(2+)"
D 1
BINDING 340 340 /ligand="Mn(2+)"
H 1
BINDING 351 351 /ligand="Mn(2+)"
H 2

Additional information [?]

Size range 388-418 amino acids
Related rules None
Fusion Nter: None Cter: None

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