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HAMAP rule MF_00740

General rule information [?]

Accession	MF_00740
Dates	26-NOV-2003 (Created) 24-JAN-2024 (Last updated, Version 30)
Name	Phosphopentomut
Scope(s)	Bacteria
Template(s)	P0A6K6 (DEOB_ECOLI); Q8DTU0 (DEOB_STRMU); [ Recover all ]
Triggered by	HAMAP; MF_00740 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DEOB
Protein name	RecName: Full=Phosphopentomutase; EC=5.4.2.7; AltName: Full=Phosphodeoxyribomutase;
Gene name	Name=deoB;

Comments [?]

FUNCTION	Isomerase that catalyzes the conversion of deoxy-ribose 1- phosphate (dRib-1-P) and ribose 1-phosphate (Rib-1-P) to deoxy-ribose 5-phosphate (dRib-5-P) and ribose 5-phosphate (Rib-5-P), respectively.
CATALYTIC ACTIVITY	Reaction=2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5- phosphate; Xref=Rhea:RHEA:27658, ChEBI:CHEBI:57259, ChEBI:CHEBI:62877; EC=5.4.2.7;
CATALYTIC ACTIVITY	Reaction=alpha-D-ribose 1-phosphate = D-ribose 5-phosphate; Xref=Rhea:RHEA:18793, ChEBI:CHEBI:57720, ChEBI:CHEBI:78346; EC=5.4.2.7;
case <FTGroup:1> and <FTGroup:2>
COFACTOR	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions.;
else
COFACTOR	Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
end case
PATHWAY	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 1/2.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the phosphopentomutase family.

Keywords [?]

Gene Ontology [?]

GO:0030145; Molecular function:manganese ion binding

GO:0008973; Molecular function:phosphopentomutase activity

GO:0006018; Biological process:2-deoxyribose 1-phosphate catabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: DEOB_STRMU (Q8DTU0)
Key	From	To	Description	Tag	Condition	FTGroup
BINDING	13	13	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		D	1
BINDING	298	298	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		D	2
BINDING	303	303	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		H	2
BINDING	339	339	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		D	1
BINDING	340	340	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="1"		H	1
BINDING	351	351	/ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="2"		H	2

Additional information [?]