HAMAP rule MF_00747
General rule information
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| Accession | MF_00747 |
| Dates | 6-JAN-2004 (Created) 26-JAN-2023 (Last updated, Version 34) |
| Name | AceK |
| Scope | Bacteria; Pseudomonadota |
| Template | P11071 (ACEK_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. |
| Catalytic activity | RHEA:43540: ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]
EC 2.7.11.5 |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the AceK family. |
Keywords
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Cytoplasm
ATP-binding
Glyoxylate bypass
Hydrolase
Kinase
Nucleotide-binding
Protein phosphatase
Serine/threonine-protein kinase
Transferase
Tricarboxylic acid cycle
ATP-binding
Glyoxylate bypass
Hydrolase
Kinase
Nucleotide-binding
Protein phosphatase
Serine/threonine-protein kinase
Transferase
Tricarboxylic acid cycle
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0008772; Molecular function: [isocitrate dehydrogenase (NADP+)] kinase activity.
GO:0006097; Biological process: glyoxylate cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0005737; Cellular component: cytoplasm.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0008772; Molecular function: [isocitrate dehydrogenase (NADP+)] kinase activity.
GO:0006097; Biological process: glyoxylate cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF06315; AceK; 1; |
Features
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| From: ACEK_ECOLI (P11071) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 315 | 321 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | A-x-G-x-x-G-[LIVMT] | ||||||||
| ACT_SITE | 371 | 371 | D | |||||||||
| BINDING | 336 | 336 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
Additional information
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| Size range | 564-625 amino acids |
| Related rules | None |
| Fusion | None |