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HAMAP rule MF_00747

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General rule information [?]

Accession MF_00747
Dates 6-JAN-2004 (Created)
26-JAN-2023 (Last updated, Version 34)
Name AceK
Bacteria; Pseudomonadota
Template P11071 (ACEK_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Isocitrate dehydrogenase kinase/phosphatase;
Short=IDH kinase/phosphatase;
EC 3.1.3.-;
Gene name

Comments [?]

Function Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
Catalytic activity RHEA:43540: ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]
Subcellular location Cytoplasm.
Similarity Belongs to the AceK family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0008772; Molecular function: [isocitrate dehydrogenase (NADP+)] kinase activity.
GO:0006097; Biological process: glyoxylate cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF06315; AceK; 1;

Features [?]

From: ACEK_ECOLI (P11071)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     315     321       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     A-x-G-x-x-G-[LIVMT]  
ACT_SITE     371     371             D  
BINDING     336     336       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     K  

Additional information [?]

Size range 564-625 amino acids
Related rules None
Fusion None