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Annotation rule MF_00747 |
Accession | MF_00747 |
Dates | 6-JAN-2004 (Created) 3-NOV-2020 (Last updated, Version 31) |
Name | AceK |
Scope | Bacteria; Proteobacteria |
Template | P11071 (ACEK_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. |
Catalytic activity | RHEA:43540: ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]
EC 2.7.11.5 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the AceK family. |
Pfam | PF06315; AceK; 1; |
From: ACEK_ECOLI (P11071) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 315 | 321 | ATP | A-x-G-x-x-G-[LIVMT] | ||||||||
ACT_SITE | 371 | 371 | D | |||||||||
BINDING | 336 | 336 | ATP | K |
Size range | 564-625 amino acids |
Related rules | None |
Fusion | None |