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HAMAP rule MF_00747

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General rule information [?]

Accession MF_00747
Dates 6-JAN-2004 (Created)
26-JAN-2023 (Last updated, Version 34)
Name AceK
Scope(s) Bacteria
Template(s) P11071 (ACEK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00747 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACEK
Protein name RecName: Full=Isocitrate dehydrogenase kinase/phosphatase;
                 Short=IDH kinase/phosphatase;
Gene name Name=aceK;

Comments [?]

FUNCTIONBifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
CATALYTIC ACTIVITY Reaction=ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O- phospho-L-seryl-[isocitrate dehydrogenase]; Xref=Rhea:RHEA:43540, Rhea:RHEA-COMP:10605, Rhea:RHEA-COMP:10606, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;
SIMILARITYBelongs to the AceK family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016788; Molecular function:hydrolase activity, acting on ester bonds
GO:0008772; Molecular function:[isocitrate dehydrogenase (NADP+)] kinase activity
GO:0006097; Biological process:glyoxylate cycle
GO:0006099; Biological process:tricarboxylic acid cycle
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF06315; AceK; 1;

Features [?]

From: ACEK_ECOLI (P11071)
Key From To Description Tag Condition FTGroup
BINDING 315 321 /ligand="ATP"
ACT_SITE 371 371 D
BINDING 336 336 /ligand="ATP"

Additional information [?]

Size range 564-625 amino acids
Related rules None
Fusion Nter: None Cter: None

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