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Annotation rule MF_00757
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General rule information [?]

Accession MF_00757
Dates 19-MAR-2004 (Created)
18-NOV-2019 (Last updated, Version 14)
Name RNase_P_4
Scope
Archaea
Templates O27655 (RNP4_METTH); O59248 (RNP4_PYRHO); P62378 (RNP4_METMP); Q58372 (RNP4_METJA); Q8U0H6 (RNP4_PYRFU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RNP4
Protein name
RecName: Full=Ribonuclease P protein component 4;
Short=RNase P component 4;
EC 3.1.26.5;
AltName: Full=Rpp21;
Gene name
rnp4

Comments [?]

Function Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Catalytic activity Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=3.1.26.5;
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Subunit Consists of a catalytic RNA component and at least 4-5 protein subunits.
Subcellular location Cytoplasm.
Similarity Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

Keywords [?]

Cytoplasm
Endonuclease
Hydrolase
Nuclease
tRNA processing
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0004526; Molecular function: ribonuclease P activity.
GO:0001682; Biological process: tRNA 5'-leader removal.
GO:0030677; Cellular component: ribonuclease P complex.
GO:0005737; Cellular component: cytoplasm.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF04032; Rpr2; 1;

Features [?]

From: RNP4_PYRHO (O59248)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     68     68       Zinc     C   1
METAL     71     71       Zinc     C   1
METAL     97     97       Zinc     C   1
METAL     100     100       Zinc     C   1

Additional information [?]

Size range 91-140 amino acids
Related rules None
Fusion None
Comments Zinc-binding residues are conserved in eukaryotes too, even though they aren't members of this family.


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