HAMAP rule MF_00757
General rule information
[?]
| Accession | MF_00757 |
| Dates | 19-MAR-2004 (Created)
19-NOV-2022 (Last updated, Version 16) |
| Name | RNase_P_4 |
| Scope(s) |
Archaea |
| Template(s) | O27655 (RNP4_METTH); O59248 (RNP4_PYRHO); P62378 (RNP4_METMP); Q58372 (RNP4_METJA); Q8U0H6 (RNP4_PYRFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00757 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | RNP4 |
| Protein name | RecName: Full=Ribonuclease P protein component 4; Short=RNase P component 4; EC=3.1.26.5; AltName: Full=Rpp21; |
| Gene name | Name=rnp4; |
Comments
[?]
| FUNCTION | Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. |
| CATALYTIC ACTIVITY | Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=3.1.26.5; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SUBUNIT | Consists of a catalytic RNA component and at least 4-5 protein subunits. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the eukaryotic/archaeal RNase P protein component 4 family. |
Keywords
[?]
| Cytoplasm | |
| Endonuclease | |
| Hydrolase | |
| Nuclease | |
| tRNA processing | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
[?]
| GO:0004526; Molecular function:ribonuclease P activity | |
| GO:0001682; Biological process:tRNA 5'-leader removal | |
| GO:0030677; Cellular component:ribonuclease P complex | |
| GO:0005737; Cellular component:cytoplasm | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
[?]
| Pfam | PF04032; Rpr2; 1; |
Features
[?]
| From: RNP4_PYRHO (O59248) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 68 | 68 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 71 | 71 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 97 | 97 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 100 | 100 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
[?]
| Size range | 91-140 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Zinc-binding residues are conserved in eukaryotes too, even though they aren't members of this family. |