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HAMAP rule MF_00757

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General rule information [?]

Accession MF_00757
Dates 19-MAR-2004 (Created)
19-NOV-2022 (Last updated, Version 16)
Name RNase_P_4
Scope(s) Archaea
Template(s) O27655 (RNP4_METTH); O59248 (RNP4_PYRHO); P62378 (RNP4_METMP); Q58372 (RNP4_METJA); Q8U0H6 (RNP4_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_00757 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RNP4
Protein name RecName: Full=Ribonuclease P protein component 4;
                 Short=RNase P component 4;
AltName: Full=Rpp21;
Gene name Name=rnp4;

Comments [?]

FUNCTIONPart of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.; EC=;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SUBUNITConsists of a catalytic RNA component and at least 4-5 protein subunits.
SIMILARITYBelongs to the eukaryotic/archaeal RNase P protein component 4 family.

Keywords [?]

Gene Ontology [?]

GO:0004526; Molecular function:ribonuclease P activity
GO:0001682; Biological process:tRNA 5'-leader removal
GO:0030677; Cellular component:ribonuclease P complex
GO:0005737; Cellular component:cytoplasm
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF04032; Rpr2; 1;

Features [?]

From: RNP4_PYRHO (O59248)
Key From To Description Tag Condition FTGroup
BINDING 68 68 /ligand="Zn(2+)"
C 1
BINDING 71 71 /ligand="Zn(2+)"
C 1
BINDING 97 97 /ligand="Zn(2+)"
C 1
BINDING 100 100 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 91-140 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Zinc-binding residues are conserved in eukaryotes too, even though they aren't members of this family.

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