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HAMAP rule MF_00766

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General rule information [?]

Accession MF_00766
Dates 8-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 37)
Name PGT_MtgA
Scope(s) Bacteria
Template(s) P46022 (MTGA_ECOLI); Q48465 (MTGA_KLEOX); [ Recover all ]
Triggered by HAMAP; MF_00766 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTGA
Protein name RecName: Full=Biosynthetic peptidoglycan transglycosylase;
AltName: Full=Glycan polymerase;
AltName: Full=Peptidoglycan glycosyltransferase MtgA;
Gene name Name=mtgA;

Comments [?]

FUNCTIONPeptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
CATALYTIC ACTIVITY Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
end case
SIMILARITYBelongs to the glycosyltransferase 51 family.

Keywords [?]

Gene Ontology [?]

GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00912; Transgly; 1;
NCBIfam TIGR02070; Mono_pep_trsgly; 1;
General Transmembrane; -; 1;

Features [?]

Additional information [?]

Size range 190-300 amino acids
Related rules None
Fusion Nter: None Cter: None

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