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HAMAP rule MF_00766

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General rule information [?]

Accession MF_00766
Dates 8-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 37)
Name PGT_MtgA
Scope
Bacteria
Templates P46022 (MTGA_ECOLI); Q48465 (MTGA_KLEOX): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTGA
Protein name
RecName: Full=Biosynthetic peptidoglycan transglycosylase;
EC 2.4.1.129;
AltName: Full=Glycan polymerase;
AltName: Full=Peptidoglycan glycosyltransferase MtgA;
Short=PGT;
Gene name
mtgA

Comments [?]

Function Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
Catalytic activity RHEA:23708: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
EC 2.4.1.129
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Subcellular location Cell inner membrane; Single-pass membrane protein.
else
Subcellular location Cell membrane; Single-pass membrane protein.
end case
Similarity Belongs to the glycosyltransferase 51 family.

Keywords [?]

case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Membrane
Peptidoglycan synthesis
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008955; Molecular function: peptidoglycan glycosyltransferase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00912; Transgly; 1;
NCBIfam TIGR02070; Mono_pep_trsgly; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Additional information [?]

Size range 190-300 amino acids
Related rules None
Fusion None


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