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HAMAP rule MF_00767

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General rule information [?]

Accession MF_00767
Dates 6-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 26)
Name Arg_catab_AstE
Scope(s) Bacteria
Template(s) P76215 (ASTE_ECOLI); Q7NU26 (ASTE_CHRVO); Q87Q40 (ASTE_VIBPA); [ Recover all ]
Triggered by HAMAP; MF_00767 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ASTE
Protein name RecName: Full=Succinylglutamate desuccinylase;
Gene name Name=astE;

Comments [?]

FUNCTIONTransforms N(2)-succinylglutamate into succinate and glutamate.
CATALYTIC ACTIVITY Reaction=H2O + N-succinyl-L-glutamate = L-glutamate + succinate; Xref=Rhea:RHEA:15169, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:30031, ChEBI:CHEBI:58763; EC=;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
PATHWAYAmino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5.
SIMILARITYBelongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.

Keywords [?]

Arginine metabolism
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016788; Molecular function:hydrolase activity, acting on ester bonds
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0019544; Biological process:arginine catabolic process to glutamate

Cross-references [?]

Pfam PF04952; AstE_AspA; 1;
PIRSF PIRSF017020; AstE; 1;
NCBIfam TIGR03242; Arg_catab_astE; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 214 214 E
BINDING 56 56 /ligand="Zn(2+)"
H 1
BINDING 59 59 /ligand="Zn(2+)"
E 1
BINDING 149 149 /ligand="Zn(2+)"
H 1

Additional information [?]

Size range 322-351 amino acids
Related rules None
Fusion Nter: None Cter: None

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