HAMAP rule MF_00767
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00767 |
| Accession | MF_00767 |
| Dates | 6-APR-2004 (Created)
2-SEP-2024 (Last updated, Version 28) |
| Name | Arg_catab_AstE |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P76215 (ASTE_ECOLI); Q7NU26 (ASTE_CHRVO); Q87Q40 (ASTE_VIBPA); [ Recover all ] |
| Triggered by |
HAMAP; MF_00767 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ASTE |
| Protein name | RecName: Full=Succinylglutamate desuccinylase; EC=3.5.1.96; |
| Gene name | Name=astE; |
Comments
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| FUNCTION | Transforms N(2)-succinylglutamate into succinate and glutamate. |
| CATALYTIC ACTIVITY | Reaction=N-succinyl-L-glutamate + H2O = L-glutamate + succinate; Xref=Rhea:RHEA:15169, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:30031, ChEBI:CHEBI:58763; EC=3.5.1.96; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| PATHWAY | Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 5/5. |
| SIMILARITY | Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. |
Keywords
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| Arginine metabolism | |
| Hydrolase | |
| case <FTGroup:1> | |
| Zinc | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0016788; Molecular function:hydrolase activity, acting on ester bonds | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0019544; Biological process:arginine catabolic process to glutamate | |
| GO:0019545; Biological process:arginine catabolic process to succinate | |
Cross-references
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| Pfam | PF04952; AstE_AspA; 1; |
| PIRSF | PIRSF017020; AstE; 1; |
| NCBIfam | TIGR03242; Arg_catab_astE; 1; |
Features
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| From: ASTE_CHRVO (Q7NU26) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 214 | 214 | E | |||||||||
| BINDING | 56 | 56 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 59 | 59 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | 1 | |||||||
| BINDING | 149 | 149 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
Additional information
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| Size range | 322-351 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |