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Annotation rule MF_00776
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General rule information [?]

Accession MF_00776
Dates 25-APR-2004 (Created)
13-JAN-2021 (Last updated, Version 19)
Name GyaR
Scope
Archaea
Templates Q9C4M5 (GYAR_THELN); O58320 (GYAR_PYRHO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GYAR
Protein name
RecName: Full=Glyoxylate reductase;
EC 1.1.1.26;
Gene name
gyaR

Comments [?]

Catalytic activity RHEA:18229: glycolate + NAD(+) = glyoxylate + H(+) + NADH
EC 1.1.1.26
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.

Keywords [?]

Cytoplasm
Oxidoreductase
NAD

Gene Ontology [?]

GO:0047964; Molecular function: glyoxylate reductase (NAD+) activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00389; 2-Hacid_dh; 1;
PF02826; 2-Hacid_dh_C; 1;
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1;
PS00670; D_2_HYDROXYACID_DH_2; 1;
PS00671; D_2_HYDROXYACID_DH_3; 1;

Features [?]

From: GYAR_THELN (Q9C4M5)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     158     161       NADP     [FLM]-G-R-I  
NP_BIND (Optional)     180     182       NADP     S-R-[ST]  
NP_BIND     239     241       NADP     [ITV]-x-R  
NP_BIND     288     290       NADP     H-x-[AG]  
ACT_SITE     241     241             R  
ACT_SITE     270     270             E  
ACT_SITE     288     288       Proton donor     H  

Additional information [?]

Size range 331-339 amino acids
Related rules None
Fusion None


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