HAMAP rule MF_00776
General rule information
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| Accession | MF_00776 |
| Dates | 25-APR-2004 (Created)
19-NOV-2022 (Last updated, Version 21) |
| Name | GyaR |
| Scope(s) |
Archaea |
| Template(s) | Q9C4M5 (GYAR_THELN); O58320 (GYAR_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00776 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GYAR |
| Protein name | RecName: Full=Glyoxylate reductase; EC=1.1.1.26; |
| Gene name | Name=gyaR; |
Comments
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| CATALYTIC ACTIVITY | Reaction=glycolate + NAD(+) = glyoxylate + H(+) + NADH; Xref=Rhea:RHEA:18229, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:36655, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.26; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily. |
Keywords
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Gene Ontology
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| GO:0047964; Molecular function:glyoxylate reductase (NAD+) activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00389; 2-Hacid_dh; 1; |
| Pfam | PF02826; 2-Hacid_dh_C; 1; |
| PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
| PROSITE | PS00670; D_2_HYDROXYACID_DH_2; 1; |
| PROSITE | PS00671; D_2_HYDROXYACID_DH_3; 1; |
Features
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| From: GYAR_THELN (Q9C4M5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 158 | 161 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[FLM]-G-R-I | ||||||||
| BINDING | 180 | 182 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
S-R-[ST] | ||||||||
| BINDING | 239 | 241 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[ITV]-x-R | ||||||||
| BINDING | 288 | 290 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
H-x-[AG] | ||||||||
| ACT_SITE | 241 | 241 | R | |||||||||
| ACT_SITE | 270 | 270 | E | |||||||||
| ACT_SITE | 288 | 288 | /note="Proton donor" | H | ||||||||
Additional information
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| Size range | 331-339 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |