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| Annotation rule MF_00776 |
General rule information
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| Accession | MF_00776 |
| Dates | 25-APR-2004 (Created) 18-NOV-2019 (Last updated, Version 18) |
| Name | GyaR |
| Scope | Archaea |
| Templates | Q9C4M5 (GYAR_THELN); O58320 (GYAR_PYRHO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Catalytic activity | RHEA:18229: glycolate + NAD(+) = glyoxylate + H(+) + NADH
EC 1.1.1.26 |
| Subunit | Homodimer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily. |
Keywords
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Gene Ontology
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GO:0047964; Molecular function: glyoxylate reductase activity.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00389; 2-Hacid_dh; 1; |
| PF02826; 2-Hacid_dh_C; 1; | |
| PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
| PS00670; D_2_HYDROXYACID_DH_2; 1; | |
| PS00671; D_2_HYDROXYACID_DH_3; 1; |
Features
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| From: GYAR_THELN (Q9C4M5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 158 | 161 | NADP | [FLM]-G-R-I | ||||||||
| NP_BIND (Optional) | 180 | 182 | NADP | S-R-[ST] | ||||||||
| NP_BIND | 239 | 241 | NADP | [ITV]-x-R | ||||||||
| NP_BIND | 288 | 290 | NADP | H-x-[AG] | ||||||||
| ACT_SITE | 241 | 241 | R | |||||||||
| ACT_SITE | 270 | 270 | E | |||||||||
| ACT_SITE | 288 | 288 | Proton donor | H | ||||||||
Additional information
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| Size range | 331-339 amino acids |
| Related rules | None |
| Fusion | None |