HAMAP rule MF_00782

General rule information [?]

Accession	MF_00782
Dates	4-MAY-2004 (Created) 1-JUN-2023 (Last updated, Version 26)

Name	Glut_biosynth

Scope

Bacteria; Bacillota

Bacteria; Pseudomonadota

Template

Q8DXM9 (GSHAB_STRA5)

Triggered by

HAMAP; MF_00782 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GSHAB

Protein name

RecName:		Full=Glutathione biosynthesis bifunctional protein GshAB;
AltName:		Full=Gamma-GCS-GS;
		Short=GCS-GS;
Includes:
	RecName:		Full=Glutamate--cysteine ligase;
			EC 6.3.2.2;
	AltName:		Full=Gamma-ECS;
			Short=GCS;
	AltName:		Full=Gamma-glutamylcysteine synthetase;
Includes:
	RecName:		Full=Glutathione synthetase;
			EC 6.3.2.3;
	AltName:		Full=GSH synthetase;
			Short=GS;
			Short=GSH-S;
			Short=GSHase;
	AltName:		Full=Glutathione synthase;

Gene name

gshAB, gshF

Comments [?]

Function	Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
Catalytic activity	RHEA:13285: ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate EC 6.3.2.2
	RHEA:13557: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate EC 6.3.2.3
Pathway	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
	Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.
Subunit	Monomer.
Similarity	In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.

Keywords [?]

ATP-binding
Glutathione biosynthesis
Ligase
Multifunctional enzyme
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004363; Molecular function: glutathione synthase activity.
GO:0004357; Molecular function: glutamate-cysteine ligase activity.
GO:0006750; Biological process: glutathione biosynthetic process.

Cross-references [?]

Pfam	PF04262; Glu_cys_ligase; 1;
NCBIfam	TIGR01435; Glu_cys_lig_rel; 1;
PROSITE	PS50975; ATP_GRASP; 1; trigger=PRU00409;

Features [?]

From: GSHAB_STRA5 (Q8DXM9)

Key From To Description Tag Condition FTGroup

REGION Nter 333 Glutamate--cysteine ligase

Additional information [?]

Size range	750-779 amino acids
Related rules	MF_00578 (GSH1)
Fusion	None

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