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HAMAP rule MF_00782

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General rule information [?]

Accession MF_00782
Dates 4-MAY-2004 (Created)
1-JUN-2023 (Last updated, Version 26)
Name Glut_biosynth
Scope(s) Bacteria
Template(s) Q8DXM9 (GSHAB_STRA5); [ Recover all ]
Triggered by HAMAP; MF_00782 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GSHAB
Protein name RecName: Full=Glutathione biosynthesis bifunctional protein GshAB;
AltName: Full=Gamma-GCS-GS;
RecName: Full=Glutamate--cysteine ligase;
AltName: Full=Gamma-ECS;
AltName: Full=Gamma-glutamylcysteine synthetase;
RecName: Full=Glutathione synthetase;
AltName: Full=GSH synthetase;
AltName: Full=Glutathione synthase;
Gene name Name=gshAB; Synonyms=gshF;

Comments [?]

FUNCTIONSynthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
CATALYTIC ACTIVITY Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate; Xref=Rhea:RHEA:13557, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:57925, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=;
PATHWAYSulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
PATHWAYSulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.
SIMILARITYIn the N-terminal section; belongs to the glutamate-- cysteine ligase type 1 family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004363; Molecular function:glutathione synthase activity
GO:0004357; Molecular function:glutamate-cysteine ligase activity
GO:0006750; Biological process:glutathione biosynthetic process

Cross-references [?]

Pfam PF04262; Glu_cys_ligase; 1;
NCBIfam TIGR01435; Glu_cys_lig_rel; 1;

Features [?]

Key From To Description Tag Condition FTGroup
REGION Nter 333 /note="Glutamate--cysteine ligase"

Additional information [?]

Size range 750-779 amino acids
Related rules MF_00578
Fusion Nter: None Cter: None

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