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Annotation rule MF_00782
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General rule information [?]

Accession MF_00782
Dates 4-MAY-2004 (Created)
18-NOV-2019 (Last updated, Version 22)
Name Glut_biosynth
Scope
Bacteria; Firmicutes
Bacteria; Proteobacteria
Template Q8DXM9 (GSHAB_STRA5)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GSHAB
Protein name
RecName: Full=Glutathione biosynthesis bifunctional protein GshAB;
AltName: Full=Gamma-GCS-GS;
Short=GCS-GS;
Includes:
RecName: Full=Glutamate--cysteine ligase;
EC 6.3.2.2;
AltName: Full=Gamma-ECS;
Short=GCS;
AltName: Full=Gamma-glutamylcysteine synthetase;
Includes:
RecName: Full=Glutathione synthetase;
EC 6.3.2.3;
AltName: Full=GSH synthetase;
Short=GS;
Short=GSH-S;
Short=GSHase;
AltName: Full=Glutathione synthase;
Gene name
gshAB, gshF

Comments [?]

Function Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
Catalytic activity RHEA:13285: ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate
EC 6.3.2.2
RHEA:13557: ATP + glycine + L-gamma-glutamyl-L-cysteine = ADP + glutathione + H(+) + phosphate
EC 6.3.2.3
Pathway Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.
Subunit Monomer.
Similarity In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004363; Molecular function: glutathione synthase activity.
GO:0004357; Molecular function: glutamate-cysteine ligase activity.
GO:0006750; Biological process: glutathione biosynthetic process.

Cross-references [?]

Pfam PF04262; Glu_cys_ligase; 1;
TIGRFAMs TIGR01435; Glu_cys_lig_rel; 1;
PROSITE PS50975; ATP_GRASP; 1; trigger=PRU00409;

Features [?]

From: GSHAB_STRA5 (Q8DXM9)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     333       Glutamate--cysteine ligase        

Additional information [?]

Size range 750-779 amino acids
Related rules MF_00578 (GSH1)
Fusion None