HAMAP rule MF_00786
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00786 |
| Accession | MF_00786 |
| Dates | 24-MAY-2004 (Created)
2-SEP-2024 (Last updated, Version 25) |
| Name | CbiT |
| Scope(s) |
Archaea |
| Template(s) | O26249 (CBIT_METTH); Q05632 (CBIT_SALTY); O87694 (CBIET_PRIMG); [ Recover all ] |
| Triggered by |
HAMAP; MF_00786 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CBIT |
| Protein name | RecName: Full=Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating); EC=2.1.1.196; |
| Gene name | Name=cbiT; |
Comments
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| FUNCTION | Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. |
| CATALYTIC ACTIVITY | Reaction=Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + S-adenosyl-L-homocysteine + CO2; Xref=Rhea:RHEA:36067, ChEBI:CHEBI:16526, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:70791, ChEBI:CHEBI:72780; EC=2.1.1.196; |
| PATHWAY | Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10. |
| SIMILARITY | Belongs to the methyltransferase superfamily. Archaeal-type CbiT family. |
Keywords
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Gene Ontology
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| GO:0008168; Molecular function:methyltransferase activity |
| GO:0019251; Biological process:anaerobic cobalamin biosynthetic process |
Cross-references
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Features
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| From: CBIT_METTH (O26249) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 41 | 45 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-x-[GC]-[TS]-G | ||||||||
| BINDING | 17 | 17 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
T | ||||||||
| BINDING | 62 | 62 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE] | ||||||||
| BINDING | 91 | 91 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[AVG] | ||||||||
Additional information
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| Size range | 163-202 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |