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HAMAP rule MF_00786

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General rule information [?]

Accession MF_00786
Dates 24-MAY-2004 (Created)
1-MAR-2024 (Last updated, Version 24)
Name CbiT
Scope(s) Archaea
Template(s) O26249 (CBIT_METTH); Q05632 (CBIT_SALTY); O87694 (CBIET_PRIMG); [ Recover all ]
Triggered by HAMAP; MF_00786 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CBIT
Protein name RecName: Full=Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating);
                 EC=2.1.1.196;
Gene name Name=cbiT;

Comments [?]

FUNCTIONCatalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
CATALYTIC ACTIVITY Reaction=Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:36067, ChEBI:CHEBI:16526, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:70791, ChEBI:CHEBI:72780; EC=2.1.1.196;
PATHWAYCofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10.
SIMILARITYBelongs to the methyltransferase superfamily. Archaeal-type CbiT family.

Keywords [?]


Gene Ontology [?]

GO:0008168; Molecular function:methyltransferase activity
GO:0019251; Biological process:anaerobic cobalamin biosynthetic process

Cross-references [?]

Pfam PF08241; Methyltransf_11; 1;
NCBIfam TIGR02469; CbiT; 1;

Features [?]

From: CBIT_METTH (O26249)
Key From To Description Tag Condition FTGroup
BINDING 41 45 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
G-x-[GC]-[TS]-G
BINDING 17 17 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
T
BINDING 62 62 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[DE]
BINDING 91 91 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[AVG]

Additional information [?]

Size range 163-202 amino acids
Related rules None
Fusion Nter: None Cter: None



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