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Annotation rule MF_00786
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General rule information [?]

Accession MF_00786
Dates 24-MAY-2004 (Created)
18-NOV-2019 (Last updated, Version 19)
Name CbiT
Scope
Archaea
Templates O26249 (CBIT_METTH); Q05632 (CBIT_SALTY); O87694 (CBIET_BACME): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CBIT
Protein name
RecName: Full=Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating);
EC 2.1.1.196;
Gene name
cbiT

Comments [?]

Function Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
Catalytic activity RHEA:36067: Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine
EC 2.1.1.196
Pathway Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10.
Similarity Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.

Keywords [?]

Cobalamin biosynthesis
Methyltransferase
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0008168; Molecular function: methyltransferase activity.
GO:0046140; Biological process: corrin biosynthetic process.

Cross-references [?]

Pfam PF08241; Methyltransf_11; 1;
TIGRFAMs TIGR02469; CbiT; 1;

Features [?]

From: CBIT_METTH (O26249)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     41     45       S-adenosyl-L-methionine binding     G-x-[GC]-[TS]-G  
BINDING     17     17       S-adenosyl-L-methionine     T  
BINDING     62     62       S-adenosyl-L-methionine     [DE]  
BINDING     91     91       S-adenosyl-L-methionine; via amide nitrogen     [AVG]  

Additional information [?]

Size range 163-202 amino acids
Related rules None
Fusion None


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