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| Annotation rule MF_00801 |
General rule information
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| Accession | MF_00801 |
| Dates | 24-NOV-2004 (Created) 14-MAY-2022 (Last updated, Version 28) |
| Name | Endonuclease_5 |
| Scope | Bacteria
Archaea |
| Templates | P68739 (NFI_ECOLI); O30108 (NFI_ARCFU); Q9X2H9 (NFI_THEMA): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. |
| Catalytic activity | Reaction=Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.; EC=3.1.21.7; |
case <FTGroup:1>
| Cofactor | Mg(2+) |
end case
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the endonuclease V family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0043737; Molecular function: deoxyribonuclease V activity.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF04493; Endonuclease_5; 1; |
Features
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| From: NFI_THEMA (Q9X2H9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 43 | 43 | /ligand="Mg(2+)" /ligand_id="18420 | D | 1 | |||||||
| BINDING | 110 | 110 | /ligand="Mg(2+)" /ligand_id="18420 | [DEN] | 1 | |||||||
| SITE | 80 | 80 | Interaction with target DNA | Y | ||||||||
Additional information
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| Size range | 191-290 amino acids |
| Related rules | None |
| Fusion | Nter: <Methyltransferase>; Cter: None |
| Comments | Some archaea are bifunctional and contain a N-terminal methyltransferase domain. |