HAMAP logo

HAMAP rule MF_00801

Send feedback

General rule information [?]

Accession MF_00801
Dates 24-NOV-2004 (Created)
19-NOV-2022 (Last updated, Version 29)
Name Endonuclease_5
Scope(s) Bacteria
Template(s) P68739 (NFI_ECOLI); O30108 (NFI_ARCFU); Q9X2H9 (NFI_THEMA); [ Recover all ]
Triggered by HAMAP; MF_00801 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NFI
Protein name RecName: Full=Endonuclease V;
AltName: Full=Deoxyinosine 3'endonuclease;
AltName: Full=Deoxyribonuclease V;
                 Short=DNase V;
Gene name Name=nfi;

Comments [?]

FUNCTIONDNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.; EC=;
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the endonuclease V family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0043737; Molecular function:deoxyribonuclease V activity
GO:0006281; Biological process:DNA repair
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF04493; Endonuclease_5; 1;

Features [?]

From: NFI_THEMA (Q9X2H9)
Key From To Description Tag Condition FTGroup
BINDING 43 43 /ligand="Mg(2+)"
D 1
BINDING 110 110 /ligand="Mg(2+)"
[DEN] 1
SITE 80 80 /note="Interaction with target DNA" Y

Additional information [?]

Size range 191-290 amino acids
Related rules None
Fusion Nter: <Methyltransferase> Cter: None
Comments Some archaea are bifunctional and contain a N-terminal methyltransferase domain.

View rule in raw text format (no links)