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Annotation rule MF_00801 |
General rule information
[?]
Accession |
MF_00801 |
Dates |
24-NOV-2004 (Created) 14-MAY-2022 (Last updated, Version 28) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Endonuclease V;
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EC 3.1.21.7;
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AltName:
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Full=Deoxyinosine 3'endonuclease;
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AltName:
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Full=Deoxyribonuclease V;
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Short=DNase V;
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Function |
DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. |
Catalytic activity |
Reaction=Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.; EC=3.1.21.7; |
case <FTGroup:1>
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the endonuclease V family. |
case <FTGroup:1>
end case
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
From: NFI_THEMA (Q9X2H9) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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43
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43
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/ligand="Mg(2+)" /ligand_id="18420
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D
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1
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BINDING
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110
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110
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/ligand="Mg(2+)" /ligand_id="18420
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[DEN]
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1
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SITE
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80
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80
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Interaction with target DNA
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Y
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Additional information
[?]
Size range |
191-290 amino acids |
Related rules |
None |
Fusion |
Nter: <Methyltransferase>; Cter: None |
Comments |
Some archaea are bifunctional and contain a N-terminal methyltransferase domain. |