HAMAP rule MF_00801

General rule information [?]

Accession	MF_00801
Dates	24-NOV-2004 (Created) 19-NOV-2022 (Last updated, Version 29)

Name	Endonuclease_5

Scope

Bacteria

Archaea

Templates

P68739 (NFI_ECOLI); O30108 (NFI_ARCFU); Q9X2H9 (NFI_THEMA): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NFI

Protein name

RecName:		Full=Endonuclease V;
		EC 3.1.21.7;
AltName:		Full=Deoxyinosine 3'endonuclease;
AltName:		Full=Deoxyribonuclease V;
		Short=DNase V;

Gene name

nfi

Comments [?]

Function	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Catalytic activity	Reaction=Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.; EC=3.1.21.7;

case <FTGroup:1>

Cofactor

end case

Subcellular location	Cytoplasm.
Similarity	Belongs to the endonuclease V family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

case <FTGroup:1>

GO:0000287; Molecular function: magnesium ion binding.

end case

GO:0043737; Molecular function: deoxyribonuclease V activity.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF04493; Endonuclease_5; 1;

Features [?]

From: NFI_THEMA (Q9X2H9)

Key From To Description Tag Condition FTGroup

BINDING 43 43 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D 1

BINDING 110 110 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 [DEN] 1

SITE 80 80 Interaction with target DNA Y

Additional information [?]

Size range	191-290 amino acids
Related rules	None
Fusion	Nter: <Methyltransferase>; Cter: None
Comments	Some archaea are bifunctional and contain a N-terminal methyltransferase domain.