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HAMAP rule MF_00801

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General rule information [?]

Accession MF_00801
Dates 24-NOV-2004 (Created)
19-NOV-2022 (Last updated, Version 29)
Name Endonuclease_5
Templates P68739 (NFI_ECOLI); O30108 (NFI_ARCFU); Q9X2H9 (NFI_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Endonuclease V;
AltName: Full=Deoxyinosine 3'endonuclease;
AltName: Full=Deoxyribonuclease V;
Short=DNase V;
Gene name

Comments [?]

Function DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
Catalytic activity Reaction=Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.; EC=;
case <FTGroup:1>
Cofactor Mg(2+)
end case
Subcellular location Cytoplasm.
Similarity Belongs to the endonuclease V family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0043737; Molecular function: deoxyribonuclease V activity.
GO:0006281; Biological process: DNA repair.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF04493; Endonuclease_5; 1;

Features [?]

From: NFI_THEMA (Q9X2H9)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     43     43       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1
BINDING     110     110       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [DEN]   1
SITE     80     80       Interaction with target DNA     Y  

Additional information [?]

Size range 191-290 amino acids
Related rules None
Fusion Nter: <Methyltransferase>; Cter: None
Comments Some archaea are bifunctional and contain a N-terminal methyltransferase domain.