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Annotation rule MF_00804 |
Accession | MF_00804 |
Dates | 20-JAN-2005 (Created) 5-MAY-2020 (Last updated, Version 21) |
Name | BADH |
Scope | Bacteria; Proteobacteria |
Templates | P17445 (BETB_ECOLI); Q9HTJ1 (BETB_PSEAE): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. |
Catalytic activity | RHEA:15305: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH
EC 1.2.1.8 |
Cofactor | K(+) Note: Binds 2 potassium ions per subunit. |
Pathway | Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. |
Subunit | Dimer of dimers. |
Similarity | Belongs to the aldehyde dehydrogenase family. |
Pfam | PF00171; Aldedh; 1; |
TIGRFAMs | TIGR01804; BADH; 1; |
PROSITE | PS00070; ALDEHYDE_DEHYDR_CYS; 1; |
PS00687; ALDEHYDE_DEHYDR_GLU; 1; |
From: BETB_PSEAE (Q9HTJ1) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 150 | 153 | NAD/NADP | G-A-W-N | ||||||||
NP_BIND | 176 | 179 | NAD/NADP | K-P-S-E | ||||||||
NP_BIND | 229 | 234 | NAD/NADP | G-x(3)-[ST]-G | ||||||||
ACT_SITE | 162 | 162 | Charge relay system | K | ||||||||
ACT_SITE | 252 | 252 | Proton acceptor | E | ||||||||
ACT_SITE | 464 | 464 | Charge relay system | E | ||||||||
METAL | 26 | 26 | Potassium 1 | [TS] | ||||||||
METAL | 27 | 27 | Potassium 1; via carbonyl oxygen | [IV] | ||||||||
METAL | 93 | 93 | Potassium 1 | [DN] | ||||||||
METAL | 180 | 180 | Potassium 1; via carbonyl oxygen | I | ||||||||
METAL | 246 | 246 | Potassium 2; via carbonyl oxygen | [LVI] | ||||||||
METAL | 457 | 457 | Potassium 2; via carbonyl oxygen | K | ||||||||
METAL | 460 | 460 | Potassium 2; via carbonyl oxygen | G | ||||||||
BINDING | 209 | 209 | NAD/NADP; via amide nitrogen | [GA] | ||||||||
BINDING | 286 | 286 | NAD/NADP | C | ||||||||
BINDING | 387 | 387 | NAD/NADP | E | ||||||||
SITE | 248 | 248 | Seems to be a necessary countercharge to the potassium cations | [ED] | ||||||||
MOD_RES | 286 | 286 | Cysteine sulfenic acid (-SOH) | C |
Size range | 481-493 amino acids |
Related rules | None |
Fusion | None |