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Annotation rule MF_00804
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General rule information [?]

Accession MF_00804
Dates 20-JAN-2005 (Created)
12-JAN-2021 (Last updated, Version 22)
Name BADH
Scope
Bacteria; Proteobacteria
Templates P17445 (BETB_ECOLI); Q9HTJ1 (BETB_PSEAE); Q3JLL8 (BETB_BURP1): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
BETB
Protein name
RecName: Full=Betaine aldehyde dehydrogenase;
Short=BADH;
EC 1.2.1.8;
Gene name
betB

Comments [?]

Function Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
Catalytic activity RHEA:15305: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH
EC 1.2.1.8
PhysiologicalDirection=left-to-right (RHEA:15306)
Cofactor K(+)
Note: Binds 2 potassium ions per subunit.
Pathway Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit Dimer of dimers.
Similarity Belongs to the aldehyde dehydrogenase family.

Keywords [?]


Gene Ontology [?]

GO:0008802; Molecular function: betaine-aldehyde dehydrogenase activity.
GO:0019285; Biological process: glycine betaine biosynthetic process from choline.

Cross-references [?]

Pfam PF00171; Aldedh; 1;
TIGRFAMs TIGR01804; BADH; 1;
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1;
PS00687; ALDEHYDE_DEHYDR_GLU; 1;

Features [?]

From: BETB_ECOLI (P17445)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     150     152       NAD     G-A-W  
NP_BIND     176     179       NAD     K-P-S-E  
NP_BIND     230     233       NAD     G-x(2)-[ST]  
ACT_SITE     162     162       Charge relay system     K  
ACT_SITE     252     252       Proton acceptor     E  
ACT_SITE     286     286       Nucleophile     C  
ACT_SITE     464     464       Charge relay system     E  
METAL     26     26       Potassium 1     [TS]  
METAL     27     27       Potassium 1; via carbonyl oxygen     [IV]  
METAL     93     93       Potassium 1     [DN]  
METAL     180     180       Potassium 1; via carbonyl oxygen     I  
METAL     246     246       Potassium 2; via carbonyl oxygen     [LVI]  
METAL     457     457       Potassium 2; via carbonyl oxygen     K  
METAL     460     460       Potassium 2; via carbonyl oxygen     G  
BINDING     254     254       NAD; via amide nitrogen     G  
BINDING     286     286       NAD;covalent     C  
BINDING     387     387       NAD     E  
SITE     248     248       Seems to be a necessary countercharge to the potassium cations     [ED]  
MOD_RES     286     286       Cysteine sulfenic acid (-SOH)     C  

Additional information [?]

Size range 481-493 amino acids
Related rules None
Fusion None
Comments BetB from P.aeruginosa can use NADP(+) with similar efficiency to NAD(+), a property that can be used by the bacterium to produce the NADPH needed to combat the oxidative stress imposed by the host defenses.