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Annotation rule MF_00804
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General rule information [?]

Accession MF_00804
Dates 20-JAN-2005 (Created)
5-MAY-2020 (Last updated, Version 21)
Name BADH
Scope
Bacteria; Proteobacteria
Templates P17445 (BETB_ECOLI); Q9HTJ1 (BETB_PSEAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
BETB
Protein name
RecName: Full=NAD/NADP-dependent betaine aldehyde dehydrogenase;
Short=BADH;
EC 1.2.1.8;
Gene name
betB

Comments [?]

Function Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.
Catalytic activity RHEA:15305: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH
EC 1.2.1.8
Cofactor K(+)
Note: Binds 2 potassium ions per subunit.
Pathway Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit Dimer of dimers.
Similarity Belongs to the aldehyde dehydrogenase family.

Keywords [?]

NAD
NADP
Oxidoreductase
Oxidation
Metal-binding
Potassium

Gene Ontology [?]

GO:0008802; Molecular function: betaine-aldehyde dehydrogenase activity.
GO:0019285; Biological process: glycine betaine biosynthetic process from choline.

Cross-references [?]

Pfam PF00171; Aldedh; 1;
TIGRFAMs TIGR01804; BADH; 1;
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1;
PS00687; ALDEHYDE_DEHYDR_GLU; 1;

Features [?]

From: BETB_PSEAE (Q9HTJ1)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     150     153       NAD/NADP     G-A-W-N  
NP_BIND     176     179       NAD/NADP     K-P-S-E  
NP_BIND     229     234       NAD/NADP     G-x(3)-[ST]-G  
ACT_SITE     162     162       Charge relay system     K  
ACT_SITE     252     252       Proton acceptor     E  
ACT_SITE     464     464       Charge relay system     E  
METAL     26     26       Potassium 1     [TS]  
METAL     27     27       Potassium 1; via carbonyl oxygen     [IV]  
METAL     93     93       Potassium 1     [DN]  
METAL     180     180       Potassium 1; via carbonyl oxygen     I  
METAL     246     246       Potassium 2; via carbonyl oxygen     [LVI]  
METAL     457     457       Potassium 2; via carbonyl oxygen     K  
METAL     460     460       Potassium 2; via carbonyl oxygen     G  
BINDING     209     209       NAD/NADP; via amide nitrogen     [GA]  
BINDING     286     286       NAD/NADP     C  
BINDING     387     387       NAD/NADP     E  
SITE     248     248       Seems to be a necessary countercharge to the potassium cations     [ED]  
MOD_RES     286     286       Cysteine sulfenic acid (-SOH)     C  

Additional information [?]

Size range 481-493 amino acids
Related rules None
Fusion None


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