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HAMAP rule MF_00811

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General rule information [?]

Accession MF_00811
Dates 30-JUN-2005 (Created)
1-JUN-2023 (Last updated, Version 25)
Name DapD
Scope(s) Bacteria
Template(s) P56220 (DAPD_UNKP); P0A9D8 (DAPD_ECOLI); Q8X8Y7 (DAPD_ECO57); [ Recover all ]
Triggered by HAMAP; MF_00811 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DAPD
Protein name RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;
                 EC=2.3.1.117;
AltName: Full=Tetrahydrodipicolinate N-succinyltransferase;
                 Short=THDP succinyltransferase;
                 Short=THP succinyltransferase;
                 Short=Tetrahydropicolinate succinylase;
Gene name Name=dapD;

Comments [?]

CATALYTIC ACTIVITY Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)- 2-succinylamino-6-oxoheptanedioate + CoA; Xref=Rhea:RHEA:17325, ChEBI:CHEBI:15377, ChEBI:CHEBI:15685, ChEBI:CHEBI:16845, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292; EC=2.3.1.117;
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.
SUBUNITHomotrimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the transferase hexapeptide repeat family.

Keywords [?]


Gene Ontology [?]

GO:0008666; Molecular function:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
GO:0019877; Biological process:diaminopimelate biosynthetic process
GO:0009089; Biological process:lysine biosynthetic process via diaminopimelate
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00132; Hexapep; 5;
NCBIfam TIGR00965; DapD; 1;
PROSITE PS00101; HEXAPEP_TRANSFERASES; 1;

Features [?]

From: DAPD_UNKP (P56220)
Key From To Description Tag Condition FTGroup
BINDING 104 104 /ligand="substrate" R
BINDING 141 141 /ligand="substrate" D

Additional information [?]

Size range 271-289 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments There is a second family of DapD (see MF_02122).



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