HAMAP rule MF_00811
General rule information
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| Accession | MF_00811 |
| Dates | 30-JUN-2005 (Created)
3-SEP-2024 (Last updated, Version 26) |
| Name | DapD |
| Scope(s) |
Bacteria |
| Template(s) | P56220 (DAPD_UNKP); P0A9D8 (DAPD_ECOLI); Q8X8Y7 (DAPD_ECO57); [ Recover all ] |
| Triggered by |
HAMAP; MF_00811 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DAPD |
| Protein name | RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; EC=2.3.1.117; AltName: Full=Tetrahydrodipicolinate N-succinyltransferase; Short=THDP succinyltransferase; Short=THP succinyltransferase; Short=Tetrahydropicolinate succinylase; |
| Gene name | Name=dapD; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)- 2-succinylamino-6-oxoheptanedioate + CoA; Xref=Rhea:RHEA:17325, ChEBI:CHEBI:15377, ChEBI:CHEBI:15685, ChEBI:CHEBI:16845, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292; EC=2.3.1.117; |
| PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. |
| SUBUNIT | Homotrimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the transferase hexapeptide repeat family. |
Keywords
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| Acyltransferase |
| Amino-acid biosynthesis |
| Cytoplasm |
| Diaminopimelate biosynthesis |
| Lysine biosynthesis |
| Repeat |
| Transferase |
Gene Ontology
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| GO:0008666; Molecular function:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity |
| GO:0019877; Biological process:diaminopimelate biosynthetic process |
| GO:0009089; Biological process:lysine biosynthetic process via diaminopimelate |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: DAPD_UNKP (P56220) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 104 | 104 | /ligand="substrate" | R | ||||||||
| BINDING | 141 | 141 | /ligand="substrate" | D | ||||||||
Additional information
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| Size range | 271-289 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | There is a second family of DapD (see MF_02122). |