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HAMAP rule MF_00820

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General rule information [?]

Accession MF_00820
Dates 29-NOV-2005 (Created)
19-NOV-2022 (Last updated, Version 16)
Name Diketo_gul_reduc
Bacteria; Gammaproteobacteria
Template P37672 (DLGD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2,3-diketo-L-gulonate reductase;
Short=2,3-DKG reductase;
AltName: Full=3-dehydro-L-gulonate 2-dehydrogenase;
Gene name

Comments [?]

Function Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
Catalytic activity RHEA:21924: 3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH
RHEA:21928: 3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0047559; Molecular function: 3-dehydro-L-gulonate 2-dehydrogenase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02615; Ldh_2; 1;

Features [?]

From: DLGD_ECOLI (P37672)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     168     174       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     x-x-M-x-D-x-S  
BINDING     224     225       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     W-K  
BINDING     304     306       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     G-x-E  
ACT_SITE     44     44       Proton donor     H  

Additional information [?]

Size range 332-332 amino acids
Related rules None
Fusion None