HAMAP rule MF_00820
General rule information
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Accession | MF_00820 |
Dates | 29-NOV-2005 (Created)
19-NOV-2022 (Last updated, Version 16) |
Name | Diketo_gul_reduc |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P37672 (DLGD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00820 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DLGD |
Protein name | RecName: Full=2,3-diketo-L-gulonate reductase; Short=2,3-DKG reductase; EC=1.1.1.130; AltName: Full=3-dehydro-L-gulonate 2-dehydrogenase; |
Gene name | Name=dlgD; |
Comments
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FUNCTION | Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. |
CATALYTIC ACTIVITY | Reaction=3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH; Xref=Rhea:RHEA:21924, ChEBI:CHEBI:15378, ChEBI:CHEBI:57441, ChEBI:CHEBI:57540, ChEBI:CHEBI:57655, ChEBI:CHEBI:57945; EC=1.1.1.130; |
CATALYTIC ACTIVITY | Reaction=3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH; Xref=Rhea:RHEA:21928, ChEBI:CHEBI:15378, ChEBI:CHEBI:57441, ChEBI:CHEBI:57655, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.130; |
SUBUNIT | Homodimer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily. |
Keywords
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Gene Ontology
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GO:0047559; Molecular function:3-dehydro-L-gulonate 2-dehydrogenase activity |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF02615; Ldh_2; 1; |
Features
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From: DLGD_ECOLI (P37672) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 168 | 174 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
x-x-M-x-D-x-S | ||||||||
BINDING | 224 | 225 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
W-K | ||||||||
BINDING | 304 | 306 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-x-E | ||||||||
ACT_SITE | 44 | 44 | /note="Proton donor" | H |
Additional information
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Size range | 332-332 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |