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HAMAP rule MF_00820

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General rule information [?]

Accession MF_00820
Dates 29-NOV-2005 (Created)
19-NOV-2022 (Last updated, Version 16)
Name Diketo_gul_reduc
Scope(s) Bacteria
Template(s) P37672 (DLGD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00820 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DLGD
Protein name RecName: Full=2,3-diketo-L-gulonate reductase;
                 Short=2,3-DKG reductase;
AltName: Full=3-dehydro-L-gulonate 2-dehydrogenase;
Gene name Name=dlgD;

Comments [?]

FUNCTIONCatalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
CATALYTIC ACTIVITY Reaction=3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH; Xref=Rhea:RHEA:21924, ChEBI:CHEBI:15378, ChEBI:CHEBI:57441, ChEBI:CHEBI:57540, ChEBI:CHEBI:57655, ChEBI:CHEBI:57945; EC=;
CATALYTIC ACTIVITY Reaction=3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH; Xref=Rhea:RHEA:21928, ChEBI:CHEBI:15378, ChEBI:CHEBI:57441, ChEBI:CHEBI:57655, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=;
SIMILARITYBelongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0047559; Molecular function:3-dehydro-L-gulonate 2-dehydrogenase activity
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02615; Ldh_2; 1;

Features [?]

From: DLGD_ECOLI (P37672)
Key From To Description Tag Condition FTGroup
BINDING 168 174 /ligand="NAD(+)"
BINDING 224 225 /ligand="NAD(+)"
BINDING 304 306 /ligand="NAD(+)"
ACT_SITE 44 44 /note="Proton donor" H

Additional information [?]

Size range 332-332 amino acids
Related rules None
Fusion Nter: None Cter: None

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