HAMAP rule MF_00820

General rule information [?]

Accession	MF_00820
Dates	29-NOV-2005 (Created) 19-NOV-2022 (Last updated, Version 16)

Name	Diketo_gul_reduc

Scope

Bacteria; Gammaproteobacteria

Template

P37672 (DLGD_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DLGD

Protein name

RecName:		Full=2,3-diketo-L-gulonate reductase;
		Short=2,3-DKG reductase;
		EC 1.1.1.130;
AltName:		Full=3-dehydro-L-gulonate 2-dehydrogenase;

Gene name

dlgD

Comments [?]

Function	Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
Catalytic activity	RHEA:21924: 3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH EC 1.1.1.130
	RHEA:21928: 3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH EC 1.1.1.130
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0047559; Molecular function: 3-dehydro-L-gulonate 2-dehydrogenase activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF02615; Ldh_2; 1;

Features [?]

From: DLGD_ECOLI (P37672)

Key From To Description Tag Condition FTGroup

BINDING 168 174 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 x-x-M-x-D-x-S

BINDING 224 225 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 W-K

BINDING 304 306 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G-x-E

ACT_SITE 44 44 Proton donor H

Additional information [?]