HAMAP rule MF_00820
General rule information
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Accession | MF_00820 |
Dates | 29-NOV-2005 (Created) 19-NOV-2022 (Last updated, Version 16) |
Name | Diketo_gul_reduc |
Scope | Bacteria; Gammaproteobacteria |
Template | P37672 (DLGD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. |
Catalytic activity | RHEA:21924: 3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH
EC 1.1.1.130 |
RHEA:21928: 3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH
EC 1.1.1.130 |
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Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily. |
Keywords
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Gene Ontology
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GO:0047559; Molecular function: 3-dehydro-L-gulonate 2-dehydrogenase activity.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF02615; Ldh_2; 1; |
Features
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From: DLGD_ECOLI (P37672) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 168 | 174 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | x-x-M-x-D-x-S | ||||||||
BINDING | 224 | 225 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | W-K | ||||||||
BINDING | 304 | 306 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G-x-E | ||||||||
ACT_SITE | 44 | 44 | Proton donor | H |
Additional information
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Size range | 332-332 amino acids |
Related rules | None |
Fusion | None |