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HAMAP rule MF_00823

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General rule information [?]

Accession MF_00823
Dates 6-FEB-2006 (Created)
13-JAN-2023 (Last updated, Version 28)
Name AcetylCoA_CT_alpha
Scope
Bacteria
Plastid
Template P0ABD5 (ACCA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ACCA
Protein name
RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha;
Short=ACCase subunit alpha;
Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha;
EC 2.1.3.15;
Gene name
accA

Comments [?]

Function Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Catalytic activity RHEA:54728: acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]
EC 2.1.3.15
Pathway Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Subunit Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
case not <OG:Chloroplast>
Subcellular location Cytoplasm.
end case
Similarity Belongs to the AccA family.

Keywords [?]

ATP-binding
case not <OG:Chloroplast>
Cytoplasm
end case
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0016743; Molecular function: carboxyl- or carbamoyltransferase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

Pfam PF03255; ACCA; 1;
PF01039; Carboxyl_trans; 1;
PF00378; ECH; 1;
PRINTS PR01069; ACCCTRFRASEA; 1;
TIGRFAMs TIGR00513; AccA; 1;
PROSITE PS50989; COA_CT_CTER; 1; trigger=PRU01137;

Additional information [?]

Size range 255-368 amino acids
Related rules None
Fusion Nter: MF_01395 (accD); Cter: None
Comments A few Bacillota encode a fusion between accD and accA (CLOTE, EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations. The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes.


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