HAMAP rule MF_00823
General rule information
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| Accession | MF_00823 |
| Dates | 6-FEB-2006 (Created)
1-JUN-2023 (Last updated, Version 29) |
| Name | AcetylCoA_CT_alpha |
| Scope(s) |
Bacteria Plastid |
| Template(s) | P0ABD5 (ACCA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00823 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACCA |
| Protein name | RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Short=ACCase subunit alpha; Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha; EC=2.1.3.15; |
| Gene name | Name=accA; |
Comments
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| FUNCTION | Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. |
| CATALYTIC ACTIVITY | Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=2.1.3.15; |
| PATHWAY | Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. |
| SUBUNIT | Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| case not <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the AccA family. |
Keywords
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| ATP-binding | |
| case not <OG:Chloroplast> | |
| Cytoplasm | |
| end case | |
| Fatty acid biosynthesis | |
| Fatty acid metabolism | |
| Lipid biosynthesis | |
| Lipid metabolism | |
| Nucleotide-binding | |
| Transferase | |
Gene Ontology
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| GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity | |
| GO:0006633; Biological process:fatty acid biosynthetic process | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
| case not <OG:Chloroplast> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
Cross-references
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| Pfam | PF03255; ACCA; 1; |
| Pfam | PF01039; Carboxyl_trans; 1; |
| Pfam | PF00378; ECH; 1; |
| PRINTS | PR01069; ACCCTRFRASEA; 1; |
| NCBIfam | TIGR00513; AccA; 1; |
| PROSITE | PS50989; COA_CT_CTER; 1; |
Features
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Additional information
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| Size range | 255-368 amino acids |
| Related rules |
None |
| Fusion | Nter: MF_01395 (accD) Cter: None |
| Comments | A few Bacillota encode a fusion between accD and accA (CLOTE, EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations. The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes. |