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HAMAP rule MF_00823

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General rule information [?]

Accession MF_00823
Dates 6-FEB-2006 (Created)
1-JUN-2023 (Last updated, Version 29)
Name AcetylCoA_CT_alpha
Scope(s) Bacteria
Template(s) P0ABD5 (ACCA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00823 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACCA
Protein name RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha;
                 Short=ACCase subunit alpha;
                 Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha;
Gene name Name=accA;

Comments [?]

FUNCTIONComponent of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
CATALYTIC ACTIVITY Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=;
PATHWAYLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
SUBUNITAcetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
case not <OG:Chloroplast>
end case
SIMILARITYBelongs to the AccA family.

Keywords [?]

Gene Ontology [?]

GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity
GO:0006633; Biological process:fatty acid biosynthetic process
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case
case not <OG:Chloroplast>
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Pfam PF03255; ACCA; 1;
Pfam PF01039; Carboxyl_trans; 1;
Pfam PF00378; ECH; 1;
NCBIfam TIGR00513; AccA; 1;

Features [?]

Additional information [?]

Size range 255-368 amino acids
Related rules None
Fusion Nter: MF_01395 (accD) Cter: None
Comments A few Bacillota encode a fusion between accD and accA (CLOTE, EUBR3, FRAAA, FRACC, FRASN, NATTJ) as do a few Actinomycetota (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations. The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes.

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