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HAMAP rule MF_00826

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General rule information [?]

Accession MF_00826
Dates 1-SEP-2006 (Created)
5-MAY-2020 (Last updated, Version 17)
Name GRDA
Scope
Bacteria
Templates P26971 (GRDA_ACESD); P52216 (GRDA_PEPLI); P50972 (GRDA1_PEPAC): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GRDA
Protein name
RecName: Full=Glycine/sarcosine/betaine reductase complex component A;
EC 1.21.4.2;
EC 1.21.4.3;
EC 1.21.4.4;
AltName: Full=Selenoprotein PA;
AltName: Full=Thioredoxin reductase complex selenoprotein A;
Gene name
grdA

Comments [?]

Function In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
Catalytic activity RHEA:12232: [thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate
EC 1.21.4.2
RHEA:12825: [thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine
EC 1.21.4.3
RHEA:11848: [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate
EC 1.21.4.4
Subunit Monomer. Component of the glycine, sarcosine and betaine reductase complexes, together with components B and C.
Similarity Belongs to the GrdA family.

Keywords [?]


Gene Ontology [?]

GO:0030699; Molecular function: glycine reductase activity.
GO:0050485; Molecular function: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor.

Cross-references [?]

Pfam PF04723; GRDA; 1;

Features [?]

From: GRDA_ACESD (P26971)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     44     44             [CU]  

Additional information [?]

Size range 150-161 amino acids
Related rules None
Fusion None