HAMAP rule MF_00835

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00835
Accession	MF_00835
Dates	27-JUN-2011 (Created) 01-JUN-2023 (Last updated, Version 8)
Name	BioC
Scope(s)	Bacteria
Template(s)	P12999; P36571; [ Recover all ]
Triggered by	HAMAP; MF_00835 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	BIOC
Protein name	RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase; Short=Malonyl-ACP O-methyltransferase; EC=2.1.1.197; AltName: Full=Biotin synthesis protein BioC;
Gene name	Name=bioC;

Comments [?]

FUNCTION	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
CATALYTIC ACTIVITY	Reaction=malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17105, Rhea:RHEA- COMP:9623, Rhea:RHEA-COMP:9954, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:78449, ChEBI:CHEBI:78845; EC=2.1.1.197;
PATHWAY	Cofactor biosynthesis; biotin biosynthesis.
SIMILARITY	Belongs to the methyltransferase superfamily.

Keywords [?]

Gene Ontology [?]

GO:0010340; Molecular function:carboxyl-O-methyltransferase activity

GO:0009102; Biological process:biotin biosynthetic process

Cross-references [?]

Features [?]

Additional information [?]

Size range	245-350 amino acids
Related rules	None
Fusion	Nter: MF_01260 (BioH) Cter: MF_00336 (BioD); <Unknown>