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HAMAP rule MF_00835

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General rule information [?]

Accession MF_00835
Dates 27-JUN-2011 (Created)
1-JUN-2023 (Last updated, Version 7)
Name BioC
Scope(s) Bacteria
Template(s) P12999 (BIOC_ECOLI); P36571 (BIOC_SERMA); [ Recover all ]
Triggered by HAMAP; MF_00835 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BIOC
Protein name RecName: Full=Malonyl-[acyl-carrier protein] O-methyltransferase;
                 Short=Malonyl-ACP O-methyltransferase;
AltName: Full=Biotin synthesis protein BioC;
Gene name Name=bioC;

Comments [?]

FUNCTIONConverts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
CATALYTIC ACTIVITY Reaction=malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:17105, Rhea:RHEA- COMP:9623, Rhea:RHEA-COMP:9954, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:78449, ChEBI:CHEBI:78845; EC=;
PATHWAYCofactor biosynthesis; biotin biosynthesis.
SIMILARITYBelongs to the methyltransferase superfamily.

Keywords [?]

Gene Ontology [?]

GO:0010340; Molecular function:carboxyl-O-methyltransferase activity
GO:0009102; Biological process:biotin biosynthetic process

Cross-references [?]

Pfam PF08241; Methyltransf_11; 1;
Pfam PF08242; Methyltransf_12; 1;
NCBIfam TIGR02072; BioC; 1;

Features [?]

Additional information [?]

Size range 245-350 amino acids
Related rules None
Fusion Nter: MF_01260 (BioH) Cter: MF_00336 (BioD); <Unknown>

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