HAMAP rule MF_00840
General rule information
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Accession | MF_00840 |
Dates | 10-MAY-2016 (Created)
18-NOV-2019 (Last updated, Version 6) |
Name | DacZ |
Scope(s) |
Archaea |
Template(s) | Q58408 (DACZ_METJA); D4GZM5 (DACZ_HALVD); [ Recover all ] |
Triggered by |
HAMAP; MF_00840 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DACZ |
Protein name | RecName: Full=Diadenylate cyclase; Short=DAC; EC=2.7.7.85; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase; |
Gene name | Name=dacZ; |
Comments
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FUNCTION | Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. |
CATALYTIC ACTIVITY | Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85; |
COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
SIMILARITY | Belongs to the adenylate cyclase family. DacZ subfamily. |
Keywords
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Gene Ontology
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GO:0004016; Molecular function:adenylate cyclase activity |
GO:0005524; Molecular function:ATP binding |
GO:0016779; Molecular function:nucleotidyltransferase activity |
GO:0030145; Molecular function:manganese ion binding |
GO:0019932; Biological process:second-messenger-mediated signaling |
Cross-references
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PROSITE | PS51794; DAC; 1; |
Pfam | PF02457; DisA_N; 1; |
PIRSF | PIRSF019073; UCP019073; 1; |
Features
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Additional information
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Size range | 239-312 amino acids |
Related rules |
MF_00838 MF_01438 MF_01499 |
Fusion | Nter: None Cter: None |
Comments | Found in some Euryarchaeota, there are also possible members in some bacteria but they are not currently annotated as such. The gene name was given in PMID 23812326. |