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HAMAP rule MF_00840

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General rule information [?]

Accession MF_00840
Dates 10-MAY-2016 (Created)
18-NOV-2019 (Last updated, Version 6)
Name DacZ
Scope(s) Archaea
Template(s) Q58408 (DACZ_METJA); D4GZM5 (DACZ_HALVD); [ Recover all ]
Triggered by HAMAP; MF_00840 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DACZ
Protein name RecName: Full=Diadenylate cyclase;
AltName: Full=Cyclic-di-AMP synthase;
                 Short=c-di-AMP synthase;
Gene name Name=dacZ;

Comments [?]

FUNCTIONDiadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
CATALYTIC ACTIVITY Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
SIMILARITYBelongs to the adenylate cyclase family. DacZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004016; Molecular function:adenylate cyclase activity
GO:0005524; Molecular function:ATP binding
GO:0016779; Molecular function:nucleotidyltransferase activity
GO:0030145; Molecular function:manganese ion binding
GO:0019932; Biological process:second-messenger-mediated signaling

Cross-references [?]

PROSITE PS51794; DAC; 1;
Pfam PF02457; DisA_N; 1;
PIRSF PIRSF019073; UCP019073; 1;

Features [?]

Additional information [?]

Size range 239-312 amino acids
Related rules MF_00838
Fusion Nter: None Cter: None
Comments Found in some Euryarchaeota, there are also possible members in some bacteria but they are not currently annotated as such. The gene name was given in PMID 23812326.

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