HAMAP logo

HAMAP rule MF_00840

Send feedback

General rule information [?]

Accession MF_00840
Dates 10-MAY-2016 (Created)
18-NOV-2019 (Last updated, Version 6)
Name DacZ
Templates Q58408 (DACZ_METJA); D4GZM5 (DACZ_HALVD): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Diadenylate cyclase;
AltName: Full=Cyclic-di-AMP synthase;
Short=c-di-AMP synthase;
Gene name

Comments [?]

Function Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
Catalytic activity RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
Cofactor Mn(2+)
Similarity Belongs to the adenylate cyclase family. DacZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004016; Molecular function: adenylate cyclase activity.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0019932; Biological process: second-messenger-mediated signaling.

Cross-references [?]

PROSITE PS51794; DAC; 1; trigger=PRU01130;
Pfam PF02457; DisA_N; 1;
PIRSF PIRSF019073; UCP019073; 1;

Additional information [?]

Size range 239-312 amino acids
Related rules MF_00838 (DACB); MF_01438 (DISA); MF_01499 (DACA)
Fusion None
Comments Found in some Euryarchaeota, there are also possible members in some bacteria but they are not currently annotated as such. The gene name was given in PMID 23812326.