HAMAP rule MF_00840

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00840
Accession	MF_00840
Dates	10-MAY-2016 (Created) 01-MAR-2024 (Last updated, Version 8)
Name	DacZ
Scope(s)	Archaea
Template(s)	Q58408; D4GZM5; [ Recover all ]
Triggered by	HAMAP; MF_00840 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DACZ
Protein name	RecName: Full=Diadenylate cyclase; Short=DAC; EC=2.7.7.85; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase;
Gene name	Name=dacZ;

Comments [?]

FUNCTION	Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
CATALYTIC ACTIVITY	Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
COFACTOR	Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
SIMILARITY	Belongs to the adenylate cyclase family. DacZ subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004016; Molecular function:adenylate cyclase activity

GO:0005524; Molecular function:ATP binding

GO:0016779; Molecular function:nucleotidyltransferase activity

GO:0030145; Molecular function:manganese ion binding

Cross-references [?]

Features [?]

Additional information [?]

Size range	239-312 amino acids
Related rules	MF_00838 MF_01438 MF_01499
Fusion	Nter: None Cter: None
Comments	Found in some Euryarchaeota, there are also possible members in some bacteria but they are not currently annotated as such. The gene name was given in PMID 23812326.