HAMAP rule MF_00840
General rule information
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Accession | MF_00840 |
Dates | 10-MAY-2016 (Created) 18-NOV-2019 (Last updated, Version 6) |
Name | DacZ |
Scope | Archaea |
Templates | Q58408 (DACZ_METJA); D4GZM5 (DACZ_HALVD): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. |
Catalytic activity | RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
EC 2.7.7.85 |
Cofactor | Mn(2+) |
Similarity | Belongs to the adenylate cyclase family. DacZ subfamily. |
Keywords
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Gene Ontology
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GO:0004016; Molecular function: adenylate cyclase activity.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0019932; Biological process: second-messenger-mediated signaling.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0019932; Biological process: second-messenger-mediated signaling.
Cross-references
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PROSITE | PS51794; DAC; 1; trigger=PRU01130; |
Pfam | PF02457; DisA_N; 1; |
PIRSF | PIRSF019073; UCP019073; 1; |
Additional information
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Size range | 239-312 amino acids |
Related rules | MF_00838 (DACB); MF_01438 (DISA); MF_01499 (DACA) |
Fusion | None |
Comments | Found in some Euryarchaeota, there are also possible members in some bacteria but they are not currently annotated as such. The gene name was given in PMID 23812326. |