HAMAP rule MF_00840

Accession	MF_00840
Dates	10-MAY-2016 (Created) 18-NOV-2019 (Last updated, Version 6)

Name

DacZ

Scope

Archaea

Templates

Q58408 (DACZ_METJA); D4GZM5 (DACZ_HALVD): [Recover all]

Triggered by

HAMAP; MF_00840 (Get profile general information and statistics)

Identifier

DACZ

Protein name

RecName: Full=Diadenylate cyclase; Short=DAC; EC 2.7.7.85; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase;

Gene name

dacZ

Function	Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
Catalytic activity	RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate EC 2.7.7.85
Cofactor	Mn(2+)
Similarity	Belongs to the adenylate cyclase family. DacZ subfamily.

ATP-binding
Manganese
Nucleotide-binding
Nucleotidyltransferase
Transferase

GO:0004016; Molecular function: adenylate cyclase activity.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0030145; Molecular function: manganese ion binding.
GO:0019932; Biological process: second-messenger-mediated signaling.

PROSITE	PS51794; DAC; 1; trigger=PRU01130;
Pfam	PF02457; DisA_N; 1;
PIRSF	PIRSF019073; UCP019073; 1;

Size range	239-312 amino acids
Related rules	MF_00838 (DACB); MF_01438 (DISA); MF_01499 (DACA)
Fusion	None
Comments	Found in some Euryarchaeota, there are also possible members in some bacteria but they are not currently annotated as such. The gene name was given in PMID 23812326.

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