HAMAP rule MF_00841
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00841 |
| Accession | MF_00841 |
| Dates | 18-MAR-2019 (Created)
15-FEB-2024 (Last updated, Version 8) |
| Name | Gtf3 |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | B5A7L9 (GTF3_STRPA); A0A0H2UR93 (GTF3_STRPN); A0A0M3KKZ0 (GTF3_STRA6); B3XPQ7 (GTF3_LIMR1); F8KEJ1 (GTF3_LIMR5); [ Recover all ] |
| Triggered by |
HAMAP; MF_00841 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GTF3 |
| Protein name | RecName: Full=Glucosyltransferase 3; EC=2.4.1.-; |
| Gene name | Name=gtf3; |
Comments
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| case <OC:Streptococcus> | |
| FUNCTION | Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring glucose from UDP-glucose to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl- [protein] resulting from the first glycosylation step. |
| else | |
| FUNCTION | Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring a sugar from a UDP-activated sugar to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L- seryl-[protein] resulting from the first glycosylation step. |
| end case | |
| PATHWAY | Protein modification; protein glycosylation. |
| SUBUNIT | Homotetramer; a dimer of dimers. |
| DOMAIN | Dimerizes via the C-terminus; dimerization is required for tetramer formation. Binds protein substrate via an exposed loop in the N-terminus. |
| SIMILARITY | Belongs to the Gtf3 glucosyltransferase family. |
Keywords
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Gene Ontology
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| case <OCellular component:Streptococcus> | |
| GO:0035251; Molecular function:UDP-glucosyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0008194; Molecular function:UDP-glycosyltransferase activity | |
| end case | |
| GO:0006486; Biological process:protein glycosylation | |
Cross-references
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| PIRSF | PIRSF007023; UDP-Galf_transf; 1; |
Features
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| From: GTF3_STRPA (B5A7L9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 244 | 249 | /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223" |
[NPS]-[FHY]-K-x-[AGS]-[AIST] | ||||||||
| BINDING | 16 | 16 | /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223" |
T | ||||||||
| BINDING | 179 | 179 | /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223" |
[KRT] | ||||||||
Additional information
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| Size range | 309-345 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |