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HAMAP rule MF_00841

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General rule information [?]

Accession MF_00841
Dates 18-MAR-2019 (Created)
13-JAN-2023 (Last updated, Version 7)
Name Gtf3
Scope
Bacteria; Bacillota
Templates B5A7L9 (GTF3_STRPA); A0A0H2UR93 (GTF3_STRPN); A0A0M3KKZ0 (GTF3_STRA6); B3XPQ7 (GTF3_LIMR1); F8KEJ1 (GTF3_LIMR5): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GTF3
Protein name
RecName: Full=Glucosyltransferase 3;
EC 2.4.1.-;
Gene name
gtf3

Comments [?]

case <OC:Streptococcus>
Function Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring glucose from UDP-glucose to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] resulting from the first glycosylation step.
else
Function Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring a sugar from a UDP-activated sugar to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] resulting from the first glycosylation step.
end case
Pathway Protein modification; protein glycosylation.
Subunit Homotetramer; a dimer of dimers.
Domain Dimerizes via the C-terminus; dimerization is required for tetramer formation. Binds protein substrate via an exposed loop in the N-terminus.
Similarity Belongs to the Gtf3 glucosyltransferase family.

Keywords [?]

Glycosyltransferase
Nucleotide-binding
Transferase

Gene Ontology [?]

case <OC:Streptococcus>
GO:0035251; Molecular function: UDP-glucosyltransferase activity.
else
GO:0008194; Molecular function: UDP-glycosyltransferase activity.
end case

Cross-references [?]

PIRSF PIRSF007023; UDP-Galf_transf; 1;

Features [?]

From: GTF3_STRPA (B5A7L9)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     244     249       /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223     [NPS]-[FHY]-K-x-[AGS]-[AIST]  
BINDING (Optional)     16     16       /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223     T  
BINDING     179     179       /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223     [KRT]  

Additional information [?]

Size range 309-345 amino acids
Related rules None
Fusion None


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