HAMAP rule MF_00841
General rule information
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Accession | MF_00841 |
Dates | 18-MAR-2019 (Created) 13-JAN-2023 (Last updated, Version 7) |
Name | Gtf3 |
Scope | Bacteria; Bacillota |
Templates | B5A7L9 (GTF3_STRPA); A0A0H2UR93 (GTF3_STRPN); A0A0M3KKZ0 (GTF3_STRA6); B3XPQ7 (GTF3_LIMR1); F8KEJ1 (GTF3_LIMR5): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
|
Gene name |
|
Comments
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case <OC:Streptococcus>
Function | Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring glucose from UDP-glucose to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] resulting from the first glycosylation step. |
else
Function | Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring a sugar from a UDP-activated sugar to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl-[protein] resulting from the first glycosylation step. |
end case
Pathway | Protein modification; protein glycosylation. |
Subunit | Homotetramer; a dimer of dimers. |
Domain | Dimerizes via the C-terminus; dimerization is required for tetramer formation. Binds protein substrate via an exposed loop in the N-terminus. |
Similarity | Belongs to the Gtf3 glucosyltransferase family. |
Keywords
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Gene Ontology
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case <OC:Streptococcus>
GO:0035251; Molecular function: UDP-glucosyltransferase activity.
else
GO:0008194; Molecular function: UDP-glycosyltransferase activity.
end case
Cross-references
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PIRSF | PIRSF007023; UDP-Galf_transf; 1; |
Features
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From: GTF3_STRPA (B5A7L9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 244 | 249 | /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223 | [NPS]-[FHY]-K-x-[AGS]-[AIST] | ||||||||
BINDING (Optional) | 16 | 16 | /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223 | T | ||||||||
BINDING | 179 | 179 | /ligand="UDP" /ligand_id="ChEBI:CHEBI:58223 | [KRT] |
Additional information
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Size range | 309-345 amino acids |
Related rules | None |
Fusion | None |