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HAMAP rule MF_00841

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General rule information [?]

Accession MF_00841
Dates 18-MAR-2019 (Created)
15-FEB-2024 (Last updated, Version 8)
Name Gtf3
Scope(s) Bacteria
Bacillota
Template(s) B5A7L9 (GTF3_STRPA); A0A0H2UR93 (GTF3_STRPN); A0A0M3KKZ0 (GTF3_STRA6); B3XPQ7 (GTF3_LIMR1); F8KEJ1 (GTF3_LIMR5); [ Recover all ]
Triggered by HAMAP; MF_00841 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GTF3
Protein name RecName: Full=Glucosyltransferase 3;
                 EC=2.4.1.-;
Gene name Name=gtf3;

Comments [?]

case <OC:Streptococcus>
FUNCTIONRequired for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring glucose from UDP-glucose to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-seryl- [protein] resulting from the first glycosylation step.
else
FUNCTIONRequired for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the second step in glycosylation by transferring a sugar from a UDP-activated sugar to the terminal GlcNAc moiety of the 3-O-(N-acetyl-alpha-D-glucosaminyl)-L- seryl-[protein] resulting from the first glycosylation step.
end case
PATHWAYProtein modification; protein glycosylation.
SUBUNITHomotetramer; a dimer of dimers.
DOMAINDimerizes via the C-terminus; dimerization is required for tetramer formation. Binds protein substrate via an exposed loop in the N-terminus.
SIMILARITYBelongs to the Gtf3 glucosyltransferase family.

Keywords [?]


Gene Ontology [?]

case <OCellular component:Streptococcus>
GO:0035251; Molecular function:UDP-glucosyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0008194; Molecular function:UDP-glycosyltransferase activity
end case
GO:0006486; Biological process:protein glycosylation

Cross-references [?]

PIRSF PIRSF007023; UDP-Galf_transf; 1;

Features [?]

From: GTF3_STRPA (B5A7L9)
Key From To Description Tag Condition FTGroup
BINDING 244 249 /ligand="UDP"
/ligand_id="ChEBI:CHEBI:58223"
[NPS]-[FHY]-K-x-[AGS]-[AIST]
BINDING 16 16 /ligand="UDP"
/ligand_id="ChEBI:CHEBI:58223"
T
BINDING 179 179 /ligand="UDP"
/ligand_id="ChEBI:CHEBI:58223"
[KRT]

Additional information [?]

Size range 309-345 amino acids
Related rules None
Fusion Nter: None Cter: None



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