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| Annotation rule MF_00842 |
General rule information
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| Accession | MF_00842 |
| Dates | 25-APR-2019 (Created) 18-NOV-2019 (Last updated, Version 4) |
| Name | OmpA |
| Scope | Bacteria; Proteobacteria |
| Template | P0A910 (OMPA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. |
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
| Function | Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. |
end case
| Subunit | Monomer and homodimer. |
| Subcellular location | Cell outer membrane; Multi-pass membrane protein. |
| Domain | The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins. |
| Similarity | Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family. |
Keywords
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case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
end case
case <FTTag:Disulfide>
end case
Gene Ontology
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GO:0009279; Cellular component: cell outer membrane.
GO:0034220; Biological process: ion transmembrane transport.
GO:0015288; Molecular function: porin activity.
GO:0034220; Biological process: ion transmembrane transport.
GO:0015288; Molecular function: porin activity.
Cross-references
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| PROSITE | PS01068; OMPA_1; 1; |
| PS51123; OMPA_2; 1; trigger=PRU00473; | |
| Pfam | PF00691; OmpA; 1; |
| PF01389; OmpA_membrane; 1; | |
| PRINTS | PR01021; OMPADOMAIN; 1; |
| PR01022; OUTRMMBRANEA; 1; |
Computed features
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| General | Signal; -; 0-1; trigger=yes; |
Features
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| From: OMPA_ECOLI (P0A910) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 27 | 37 | Beta stranded | |||||||||
| TRANSMEM | 55 | 66 | Beta stranded | |||||||||
| TRANSMEM | 70 | 78 | Beta stranded | |||||||||
| TRANSMEM | 96 | 107 | Beta stranded | |||||||||
| TRANSMEM | 112 | 120 | Beta stranded | |||||||||
| TRANSMEM | 142 | 151 | Beta stranded | |||||||||
| TRANSMEM | 156 | 163 | Beta stranded | |||||||||
| TRANSMEM | 182 | 190 | Beta stranded | |||||||||
| SITE | 73 | 73 | Part of salt bridge gating mechanism | E | ||||||||
| SITE | 159 | 159 | Part of salt bridge gating mechanism | R | ||||||||
| DISULFID (Optional) | 311 | 323 | Disulfide | C-x*-C | ||||||||
Additional information
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| Size range | 320-390 amino acids |
| Related rules | None |
| Fusion | None |