HAMAP rule MF_00842
General rule information
[?]
| Accession | MF_00842 |
| Dates | 25-APR-2019 (Created) 7-FEB-2023 (Last updated, Version 7) |
| Name | OmpA |
| Scope | Bacteria; Pseudomonadota |
| Template | P0A910 (OMPA_ECOLI) |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||
| Gene name |
|
Comments
[?]
| Function | With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. |
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
| Function | Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. |
end case
| Subunit | Monomer and homodimer. |
| Subcellular location | Cell outer membrane; Multi-pass membrane protein. |
| Domain | The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins. |
| Similarity | Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family. |
Keywords
[?]
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
end case
case <FTTag:Disulfide>
end case
Gene Ontology
[?]
GO:0009279; Cellular component: cell outer membrane.
GO:0034220; Biological process: monoatomic ion transmembrane transport.
GO:0015288; Molecular function: porin activity.
GO:0034220; Biological process: monoatomic ion transmembrane transport.
GO:0015288; Molecular function: porin activity.
Cross-references
[?]
| PROSITE | PS01068; OMPA_1; 1; |
| PS51123; OMPA_2; 1; trigger=PRU00473; | |
| Pfam | PF00691; OmpA; 1; |
| PF01389; OmpA_membrane; 1; | |
| PRINTS | PR01021; OMPADOMAIN; 1; |
| PR01022; OUTRMMBRANEA; 1; |
Computed features
[?]
| General | Signal; -; 0-1; trigger=yes; |
Features
[?]
| From: OMPA_ECOLI (P0A910) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 27 | 37 | Beta stranded | |||||||||
| TRANSMEM | 55 | 66 | Beta stranded | |||||||||
| TRANSMEM | 70 | 78 | Beta stranded | |||||||||
| TRANSMEM | 96 | 107 | Beta stranded | |||||||||
| TRANSMEM | 112 | 120 | Beta stranded | |||||||||
| TRANSMEM | 142 | 151 | Beta stranded | |||||||||
| TRANSMEM | 156 | 163 | Beta stranded | |||||||||
| TRANSMEM | 182 | 190 | Beta stranded | |||||||||
| SITE | 73 | 73 | Part of salt bridge gating mechanism | E | ||||||||
| SITE | 159 | 159 | Part of salt bridge gating mechanism | R | ||||||||
| DISULFID (Optional) | 311 | 323 | Disulfide | C-x*-C | ||||||||
Additional information
[?]
| Size range | 320-390 amino acids |
| Related rules | None |
| Fusion | None |