HAMAP rule MF_00842
General rule information
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| Accession | MF_00842 |
| Dates | 25-APR-2019 (Created)
7-FEB-2023 (Last updated, Version 7) |
| Name | OmpA |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0A910 (OMPA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00842 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | OMPA |
| Protein name | RecName: Full=Outer membrane protein A; AltName: Full=Outer membrane porin A; |
| Gene name | Name=ompA; |
Comments
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| FUNCTION | With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage. |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia> | |
| FUNCTION | Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. |
| end case | |
| SUBUNIT | Monomer and homodimer. |
| SUBCELLULAR LOCATION | Cell outer membrane; Multi-pass membrane protein. |
| DOMAIN | The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins. |
| SIMILARITY | Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family. |
Keywords
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| Cell outer membrane | |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia> | |
| Conjugation | |
| end case | |
| case <FTTag:Disulfide> | |
| Disulfide bond | |
| end case | |
| Ion transport | |
| Membrane | |
| Porin | |
| Transmembrane | |
| Transmembrane beta strand | |
| Transport | |
Gene Ontology
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| GO:0009279; Cellular component:cell outer membrane |
| GO:0034220; Biological process:monoatomic ion transmembrane transport |
| GO:0015288; Molecular function:porin activity |
Cross-references
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| PROSITE | PS01068; OMPA_1; 1; |
| PROSITE | PS51123; OMPA_2; 1; |
| Pfam | PF00691; OmpA; 1; |
| Pfam | PF01389; OmpA_membrane; 1; |
| PRINTS | PR01021; OMPADOMAIN; 1; |
| PRINTS | PR01022; OUTRMMBRANEA; 1; |
| General | Signal; -; 0-1; |
Features
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| From: OMPA_ECOLI (P0A910) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 27 | 37 | /note="Beta stranded" | |||||||||
| TRANSMEM | 55 | 66 | /note="Beta stranded" | |||||||||
| TRANSMEM | 70 | 78 | /note="Beta stranded" | |||||||||
| TRANSMEM | 96 | 107 | /note="Beta stranded" | |||||||||
| TRANSMEM | 112 | 120 | /note="Beta stranded" | |||||||||
| TRANSMEM | 142 | 151 | /note="Beta stranded" | |||||||||
| TRANSMEM | 156 | 163 | /note="Beta stranded" | |||||||||
| TRANSMEM | 182 | 190 | /note="Beta stranded" | |||||||||
| SITE | 73 | 73 | /note="Part of salt bridge gating mechanism" | E | ||||||||
| SITE | 159 | 159 | /note="Part of salt bridge gating mechanism" | R | ||||||||
| DISULFID | 311 | 323 | Disulfide | C-x*-C | ||||||||
Additional information
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| Size range | 320-390 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |