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HAMAP rule MF_00842

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General rule information [?]

Accession MF_00842
Dates 25-APR-2019 (Created)
7-FEB-2023 (Last updated, Version 7)
Name OmpA
Scope(s) Bacteria
Template(s) P0A910 (OMPA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00842 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier OMPA
Protein name RecName: Full=Outer membrane protein A;
AltName: Full=Outer membrane porin A;
Gene name Name=ompA;

Comments [?]

FUNCTIONWith TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
FUNCTIONRequired for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
end case
SUBUNITMonomer and homodimer.
SUBCELLULAR LOCATIONCell outer membrane; Multi-pass membrane protein.
DOMAINThe extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.
SIMILARITYBelongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.

Keywords [?]

Cell outer membrane
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
end case
case <FTTag:Disulfide>
Disulfide bond
end case
Ion transport
Transmembrane beta strand

Gene Ontology [?]

GO:0009279; Cellular component:cell outer membrane
GO:0034220; Biological process:monoatomic ion transmembrane transport
GO:0015288; Molecular function:porin activity

Cross-references [?]

PROSITE PS01068; OMPA_1; 1;
PROSITE PS51123; OMPA_2; 1;
Pfam PF00691; OmpA; 1;
Pfam PF01389; OmpA_membrane; 1;
General Signal; -; 0-1;

Features [?]

From: OMPA_ECOLI (P0A910)
Key From To Description Tag Condition FTGroup
TRANSMEM 27 37 /note="Beta stranded"
TRANSMEM 55 66 /note="Beta stranded"
TRANSMEM 70 78 /note="Beta stranded"
TRANSMEM 96 107 /note="Beta stranded"
TRANSMEM 112 120 /note="Beta stranded"
TRANSMEM 142 151 /note="Beta stranded"
TRANSMEM 156 163 /note="Beta stranded"
TRANSMEM 182 190 /note="Beta stranded"
SITE 73 73 /note="Part of salt bridge gating mechanism" E
SITE 159 159 /note="Part of salt bridge gating mechanism" R
DISULFID 311 323 Disulfide C-x*-C

Additional information [?]

Size range 320-390 amino acids
Related rules None
Fusion Nter: None Cter: None

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