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HAMAP rule MF_00842

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General rule information [?]

Accession MF_00842
Dates 25-APR-2019 (Created)
7-FEB-2023 (Last updated, Version 7)
Name OmpA
Bacteria; Pseudomonadota
Template P0A910 (OMPA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Outer membrane protein A;
AltName: Full=Outer membrane porin A;
Gene name

Comments [?]

Function With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
Function Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
end case
Subunit Monomer and homodimer.
Subcellular location Cell outer membrane; Multi-pass membrane protein.
Domain The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.
Similarity Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.

Keywords [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> or <OC:Klebsiella> or <OC:Erwinia>
end case
case <FTTag:Disulfide>
end case

Gene Ontology [?]

GO:0009279; Cellular component: cell outer membrane.
GO:0034220; Biological process: monoatomic ion transmembrane transport.
GO:0015288; Molecular function: porin activity.

Cross-references [?]

PROSITE PS01068; OMPA_1; 1;
PS51123; OMPA_2; 1; trigger=PRU00473;
Pfam PF00691; OmpA; 1;
PF01389; OmpA_membrane; 1;

Computed features [?]

General Signal; -; 0-1; trigger=yes;

Features [?]

From: OMPA_ECOLI (P0A910)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     27     37       Beta stranded        
TRANSMEM     55     66       Beta stranded        
TRANSMEM     70     78       Beta stranded        
TRANSMEM     96     107       Beta stranded        
TRANSMEM     112     120       Beta stranded        
TRANSMEM     142     151       Beta stranded        
TRANSMEM     156     163       Beta stranded        
TRANSMEM     182     190       Beta stranded        
SITE     73     73       Part of salt bridge gating mechanism     E  
SITE     159     159       Part of salt bridge gating mechanism     R  
DISULFID (Optional)     311     323           Disulfide   C-x*-C  

Additional information [?]

Size range 320-390 amino acids
Related rules None
Fusion None