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HAMAP rule MF_00843

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General rule information [?]

Accession MF_00843
Dates 21-MAY-2019 (Created)
26-JAN-2023 (Last updated, Version 6)
Name Lpp
Scope
Bacteria; Pseudomonadota
Template P69776 (LPP_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPP
Protein name
RecName: Full=Major outer membrane lipoprotein Lpp;
case <OC:Escherichia> or <OC:Yersinia> or <OC:Salmonella>
Protein name
AltName: Full=Braun lipoprotein;
Short=BLP;
end case
case <OC:Escherichia> or <OC:Salmonella>
Protein name
AltName: Full=Murein lipoprotein;
end case
Protein name
Flags: Precursor;
Gene name
lpp

Comments [?]

Function A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
Subunit Homotrimer.
Subcellular location Cell outer membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall; Peptidoglycan-anchor. Note=Attached via its lipidated N-terminus to the inner leaflet of the outer membrane. Attached to the peptidoglycan network (PGN) via its C-terminus.
Similarity Belongs to the Lpp family.

Keywords [?]

Cell outer membrane
Cell wall
Lipoprotein
Membrane
Palmitate
Peptidoglycan-anchor
Repeat
Secreted

Gene Ontology [?]

GO:0009279; Cellular component: cell outer membrane.
GO:0008289; Molecular function: lipid binding.
GO:0042834; Molecular function: peptidoglycan binding.
GO:0030258; Biological process: lipid modification.
GO:0043580; Biological process: periplasmic space organization.

Cross-references [?]

PROSITE PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303;
Pfam PF04728; LPP; 1;
PIRSF PIRSF002855; Murein-lipoprotein; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Features [?]

From: LPP_ECOLI (P69776)
Key     From     To       Description   Tag   Condition   FTGroup
REPEAT     24     34                
REPEAT     38     48                
MOD_RES     78     78       N6-murein peptidoglycan lysine     K  
LIPID     21     21       N-palmitoyl cysteine     C  
LIPID     21     21       S-diacylglycerol cysteine     C  

Additional information [?]

Size range 62-119 amino acids
Related rules None
Fusion None
Comments Quite similar to YqhH, but it has a C-terminal Glu residue. Duplicated in Salmonella.


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