HAMAP rule MF_00843
General rule information
[?]
| Accession | MF_00843 |
| Dates | 21-MAY-2019 (Created)
26-JAN-2023 (Last updated, Version 6) |
| Name | Lpp |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P69776 (LPP_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00843 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | LPP |
| Protein name | RecName: Full=Major outer membrane lipoprotein Lpp; |
| case <OC:Escherichia> or <OC:Yersinia> or <OC:Salmonella> | |
| Protein name | AltName: Full=Braun lipoprotein; Short=BLP; |
| end case | |
| case <OC:Escherichia> or <OC:Salmonella> | |
| Protein name | AltName: Full=Murein lipoprotein; |
| end case | |
| Protein name | Flags: Precursor; |
| Gene name | Name=lpp; |
Comments
[?]
| FUNCTION | A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. |
| SUBUNIT | Homotrimer. |
| SUBCELLULAR LOCATION | Cell outer membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall; Peptidoglycan-anchor. Note=Attached via its lipidated N-terminus to the inner leaflet of the outer membrane. Attached to the peptidoglycan network (PGN) via its C-terminus. |
| SIMILARITY | Belongs to the Lpp family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0009279; Cellular component:cell outer membrane |
| GO:0008289; Molecular function:lipid binding |
| GO:0042834; Molecular function:peptidoglycan binding |
| GO:0030258; Biological process:lipid modification |
| GO:0043580; Biological process:periplasmic space organization |
Cross-references
[?]
| PROSITE | PS51257; PROKAR_LIPOPROTEIN; 1; |
| Pfam | PF04728; LPP; 1; |
| PIRSF | PIRSF002855; Murein-lipoprotein; 1; |
| General | Coiled_coil; -; 0-unlimited; |
Features
[?]
| From: LPP_ECOLI (P69776) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | 24 | 34 | ||||||||||
| REPEAT | 38 | 48 | ||||||||||
| MOD_RES | 78 | 78 | /note="N6-murein peptidoglycan lysine" | K | ||||||||
| LIPID | 21 | 21 | /note="N-palmitoyl cysteine" | C | ||||||||
| LIPID | 21 | 21 | /note="S-diacylglycerol cysteine" | C | ||||||||
Additional information
[?]
| Size range | 62-119 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Quite similar to YqhH, but it has a C-terminal Glu residue. Duplicated in Salmonella. |