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HAMAP rule MF_00843

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General rule information [?]

Accession MF_00843
Dates 21-MAY-2019 (Created)
26-JAN-2023 (Last updated, Version 6)
Name Lpp
Scope(s) Bacteria
Template(s) P69776 (LPP_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00843 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPP
Protein name RecName: Full=Major outer membrane lipoprotein Lpp;
case <OC:Escherichia> or <OC:Yersinia> or <OC:Salmonella>
Protein name AltName: Full=Braun lipoprotein;
end case
case <OC:Escherichia> or <OC:Salmonella>
Protein name AltName: Full=Murein lipoprotein;
end case
Protein name Flags: Precursor;
Gene name Name=lpp;

Comments [?]

FUNCTIONA highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
SUBCELLULAR LOCATIONCell outer membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall; Peptidoglycan-anchor. Note=Attached via its lipidated N-terminus to the inner leaflet of the outer membrane. Attached to the peptidoglycan network (PGN) via its C-terminus.
SIMILARITYBelongs to the Lpp family.

Keywords [?]

Gene Ontology [?]

GO:0009279; Cellular component:cell outer membrane
GO:0008289; Molecular function:lipid binding
GO:0042834; Molecular function:peptidoglycan binding
GO:0030258; Biological process:lipid modification
GO:0043580; Biological process:periplasmic space organization

Cross-references [?]

Pfam PF04728; LPP; 1;
PIRSF PIRSF002855; Murein-lipoprotein; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

From: LPP_ECOLI (P69776)
Key From To Description Tag Condition FTGroup
REPEAT 24 34
REPEAT 38 48
MOD_RES 78 78 /note="N6-murein peptidoglycan lysine" K
LIPID 21 21 /note="N-palmitoyl cysteine" C
LIPID 21 21 /note="S-diacylglycerol cysteine" C

Additional information [?]

Size range 62-119 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Quite similar to YqhH, but it has a C-terminal Glu residue. Duplicated in Salmonella.

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