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HAMAP rule MF_00844

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General rule information [?]

Accession MF_00844
Dates 29-JUL-2019 (Created)
18-NOV-2019 (Last updated, Version 4)
Name RqcH
Templates O34693 (RQCH_BACSU); Q59020 (RQCH_METJA): [Recover all]
case <OC:Bacteria>
end case

case <OC:Archaea>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacteria>
Protein name
RecName: Full=Rqc2 homolog RqcH;
else case <OC:Archaea>
Protein name
RecName: Full=Archaeal Rqc2 homolog aRqcH;
end case
Gene name

Comments [?]

case <OC:Bacteria>
Function Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
else case <OC:Archaea>
Function Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
end case
Subunit Associates with stalled 50S ribosomal subunits.
Similarity Belongs to the NEMF family.

Keywords [?]

case <Feature:coiled>
end case

Gene Ontology [?]

GO:0000049; Molecular function: tRNA binding.
GO:0043023; Molecular function: ribosomal large subunit binding.
GO:0072344; Biological process: rescue of stalled ribosome.

Cross-references [?]

Pfam PF05670; NFACT-R_1; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited;

Additional information [?]

case <OC:Bacteria>
Size range 500-740 amino acids
end case
case <OC:Archaea>
Size range 560-800 amino acids
end case
Related rules None
Fusion None