HAMAP rule MF_00844

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00844
Accession	MF_00844
Dates	29-JUL-2019 (Created) 02-SEP-2024 (Last updated, Version 6)
Name	RqcH
Scope(s)	Bacteria Archaea
Template(s)	O34693; Q59020; [ Recover all ]
Triggered by	case c? <OC:Bacteria> HAMAP; MF_00844_B (Get profile general information and statistics) end case case c? <OC:Archaea> HAMAP; MF_00844_A (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RQCH
case <OC:Bacteria>
Protein name	RecName: Full=Rqc2 homolog RqcH; Short=RqcH;
else case <OC:Archaea>
Protein name	RecName: Full=Archaeal Rqc2 homolog aRqcH; Short=aRqcH;
end case
Gene name	Name=rqcH;

Comments [?]

case <OC:Bacteria>
FUNCTION	Key component of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. RqcH recruits Ala-charged tRNA, and with RqcP directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal alanine extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
SUBUNIT	Associates with stalled 50S ribosomal subunits. Binds to RqcP.
else case <OC:Archaea>
FUNCTION	Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
SUBUNIT	Associates with stalled 50S ribosomal subunits.
end case
SIMILARITY	Belongs to the NEMF family.

Keywords [?]

Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding

GO:0000049; Molecular function:tRNA binding

GO:0043023; Molecular function:ribosomal large subunit binding

GO:0072344; Biological process:rescue of stalled ribosome

Cross-references [?]

Pfam	PF05670; NFACT-R_1; 1;
General	Coiled_coil; -; 0-unlimited;

Features [?]

Additional information [?]