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HAMAP rule MF_00844

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General rule information [?]

Accession MF_00844
Dates 29-JUL-2019 (Created)
18-NOV-2019 (Last updated, Version 4)
Name RqcH
Scope(s) Bacteria
Template(s) O34693 (RQCH_BACSU); Q59020 (RQCH_METJA); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_00844_B (Get profile general information and statistics)
end case
case c? <OC:Archaea>
HAMAP; MF_00844_A (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RQCH
case <OC:Bacteria>
Protein name RecName: Full=Rqc2 homolog RqcH;
else case <OC:Archaea>
Protein name RecName: Full=Archaeal Rqc2 homolog aRqcH;
end case
Gene name Name=rqcH;

Comments [?]

case <OC:Bacteria>
FUNCTIONPart of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
else case <OC:Archaea>
FUNCTIONProbably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
end case
SUBUNITAssociates with stalled 50S ribosomal subunits.
SIMILARITYBelongs to the NEMF family.

Keywords [?]

case <Feature:coiled>
Coiled coil
end case
Protein biosynthesis

Gene Ontology [?]

GO:0000049; Molecular function:tRNA binding
GO:0043023; Molecular function:ribosomal large subunit binding
GO:0072344; Biological process:rescue of stalled ribosome

Cross-references [?]

Pfam PF05670; NFACT-R_1; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

Additional information [?]

Size range 560-800 amino acids
Related rules None
Fusion Nter: None Cter: None

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