HAMAP rule MF_00844

General rule information [?]

Accession	MF_00844
Dates	29-JUL-2019 (Created) 18-NOV-2019 (Last updated, Version 4)
Name	RqcH
Scope(s)	Bacteria Archaea
Template(s)	O34693 (RQCH_BACSU); Q59020 (RQCH_METJA); [ Recover all ]
Triggered by	case c? <OC:Bacteria> HAMAP; MF_00844_B (Get profile general information and statistics) end case case c? <OC:Archaea> HAMAP; MF_00844_A (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RQCH
case <OC:Bacteria>
Protein name	RecName: Full=Rqc2 homolog RqcH; Short=RqcH;
else case <OC:Archaea>
Protein name	RecName: Full=Archaeal Rqc2 homolog aRqcH; Short=aRqcH;
end case
Gene name	Name=rqcH;

Comments [?]

case <OC:Bacteria>
FUNCTION	Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
else case <OC:Archaea>
FUNCTION	Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.
end case
SUBUNIT	Associates with stalled 50S ribosomal subunits.
SIMILARITY	Belongs to the NEMF family.

Keywords [?]

Gene Ontology [?]

GO:0000049; Molecular function:tRNA binding

GO:0043023; Molecular function:ribosomal large subunit binding

GO:0072344; Biological process:rescue of stalled ribosome

Cross-references [?]

Pfam	PF05670; NFACT-R_1; 1;
General	Coiled_coil; -; 0-unlimited;

Features [?]

Additional information [?]