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| Annotation rule MF_00844 |
General rule information
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| Accession | MF_00844 |
| Dates | 29-JUL-2019 (Created) 18-NOV-2019 (Last updated, Version 4) |
| Name | RqcH |
| Scope | Bacteria
Archaea |
| Templates | O34693 (RQCH_BACSU); Q59020 (RQCH_METJA): [Recover all] |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
case <OC:Bacteria>
| Protein name |
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else case <OC:Archaea>
| Protein name |
|
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end case
| Gene name |
|
Comments
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case <OC:Bacteria>
| Function | Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. |
else case <OC:Archaea>
| Function | Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. |
end case
| Subunit | Associates with stalled 50S ribosomal subunits. |
| Similarity | Belongs to the NEMF family. |
Keywords
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case <Feature:coiled>
end case
Gene Ontology
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GO:0000049; Molecular function: tRNA binding.
GO:0043023; Molecular function: ribosomal large subunit binding.
GO:0072344; Biological process: rescue of stalled ribosome.
GO:0043023; Molecular function: ribosomal large subunit binding.
GO:0072344; Biological process: rescue of stalled ribosome.
Cross-references
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| Pfam | PF05670; NFACT-R_1; 1; |
Computed features
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| General | Coiled_coil; -; 0-unlimited; |
Additional information
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case <OC:Bacteria>
| Size range | 500-740 amino acids |
end case
case <OC:Archaea>
| Size range | 560-800 amino acids |
end case
| Related rules | None |
| Fusion | None |