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Annotation rule MF_00844 |
Accession | MF_00844 |
Dates | 29-JUL-2019 (Created) 18-NOV-2019 (Last updated, Version 4) |
Name | RqcH |
Scope | Bacteria
Archaea |
Templates | O34693 (RQCH_BACSU); Q59020 (RQCH_METJA): [Recover all] |
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Function | Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. |
Function | Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation. |
Subunit | Associates with stalled 50S ribosomal subunits. |
Similarity | Belongs to the NEMF family. |
Pfam | PF05670; NFACT-R_1; 1; |
General | Coiled_coil; -; 0-unlimited; |
Size range | 500-740 amino acids |
Size range | 560-800 amino acids |
Related rules | None |
Fusion | None |