HAMAP rule MF_00849
General rule information
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| Accession | MF_00849 |
| Dates | 10-FEB-2020 (Created) 1-JUN-2023 (Last updated, Version 6) |
| Name | BipA |
| Scope | Bacteria |
| Templates | P0DTT0 (BIPA_ECOLI); P0A3B2 (BIPA_ECO27); H9L427 (BIPA_SALTY): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA. |
| Catalytic activity | RHEA:19669: GTP + H2O = GDP + H(+) + phosphate |
| Subunit | Monomer. |
| Subcellular location | Cytoplasm. Note=Binds to ribosomes. |
| Similarity | Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily. |
Keywords
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Cytoplasm
GTP-binding
Hydrolase
Nucleotide-binding
Ribosome biogenesis
RNA-binding
rRNA-binding
tRNA-binding
GTP-binding
Hydrolase
Nucleotide-binding
Ribosome biogenesis
RNA-binding
rRNA-binding
tRNA-binding
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0043022; Molecular function: ribosome binding.
GO:0000027; Biological process: ribosomal large subunit assembly.
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0043022; Molecular function: ribosome binding.
GO:0000027; Biological process: ribosomal large subunit assembly.
Cross-references
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| PROSITE | PS00301; G_TR_1; 1; |
| PS51722; G_TR_2; 1; trigger=PRU01059; | |
| Pfam | PF00679; EFG_C; 1; |
| PF00009; GTP_EFTU; 1; | |
| PF03144; GTP_EFTU_D2; 1; | |
| PRINTS | PR00315; ELONGATNFCT; 1; |
| NCBIfam | TIGR00231; small_GTP; 1; |
| TIGR01394; TypA_BipA; 1; |
Features
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| From: BIPA_ECOLI (P0DTT0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 15 | 20 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-[HA]-G-K-[ST]-[ST] | ||||||||
| BINDING | 128 | 131 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | N-K-[ITV]-D | ||||||||
Additional information
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| Size range | 575-643 amino acids |
| Related rules | None |
| Fusion | None |