HAMAP rule MF_00849

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00849
Accession	MF_00849
Dates	10-FEB-2020 (Created) 03-SEP-2024 (Last updated, Version 8)
Name	BipA
Scope(s)	Bacteria
Template(s)	P0DTT0; P0A3B2; H9L427; [ Recover all ]
Triggered by	HAMAP; MF_00849 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	BIPA
Protein name	RecName: Full=Large ribosomal subunit assembly factor BipA; EC=3.6.5.-; AltName: Full=GTP-binding protein BipA;
Gene name	Name=bipA;

Comments [?]

FUNCTION	A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
CATALYTIC ACTIVITY	Reaction=GTP + H2O = GDP + phosphate + H(+); Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
SUBUNIT	Monomer.
SUBCELLULAR LOCATION	Cytoplasm. Note=Binds to ribosomes.
SIMILARITY	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm

GO:0005525; Molecular function:GTP binding

GO:0003924; Molecular function:GTPase activity

GO:0043022; Molecular function:ribosome binding

GO:0000027; Biological process:ribosomal large subunit assembly

Cross-references [?]

Features [?]

From: BIPA_ECOLI (P0DTT0)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

D-[HA]-G-K-[ST]-[ST]

BINDING

128

131

/ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"

N-K-[ITV]-D

Additional information [?]