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HAMAP rule MF_00849

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General rule information [?]

Accession MF_00849
Dates 10-FEB-2020 (Created)
1-JUN-2023 (Last updated, Version 6)
Name BipA
Templates P0DTT0 (BIPA_ECOLI); P0A3B2 (BIPA_ECO27); H9L427 (BIPA_SALTY): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Large ribosomal subunit assembly factor BipA;
EC 3.6.5.-;
AltName: Full=GTP-binding protein BipA;
Gene name

Comments [?]

Function A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
Catalytic activity RHEA:19669: GTP + H2O = GDP + H(+) + phosphate
Subunit Monomer.
Subcellular location Cytoplasm. Note=Binds to ribosomes.
Similarity Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0043022; Molecular function: ribosome binding.
GO:0000027; Biological process: ribosomal large subunit assembly.

Cross-references [?]

PROSITE PS00301; G_TR_1; 1;
PS51722; G_TR_2; 1; trigger=PRU01059;
Pfam PF00679; EFG_C; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
NCBIfam TIGR00231; small_GTP; 1;
TIGR01394; TypA_BipA; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     15     20       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-[HA]-G-K-[ST]-[ST]  
BINDING     128     131       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     N-K-[ITV]-D  

Additional information [?]

Size range 575-643 amino acids
Related rules None
Fusion None