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HAMAP rule MF_00849

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General rule information [?]

Accession MF_00849
Dates 10-FEB-2020 (Created)
1-JUN-2023 (Last updated, Version 6)
Name BipA
Scope(s) Bacteria
Template(s) P0DTT0 (BIPA_ECOLI); P0A3B2 (BIPA_ECO27); H9L427 (BIPA_SALTY); [ Recover all ]
Triggered by HAMAP; MF_00849 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BIPA
Protein name RecName: Full=Large ribosomal subunit assembly factor BipA;
AltName: Full=GTP-binding protein BipA;
Gene name Name=bipA;

Comments [?]

FUNCTIONA 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
CATALYTIC ACTIVITY Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
SUBCELLULAR LOCATIONCytoplasm. Note=Binds to ribosomes.
SIMILARITYBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
GO:0043022; Molecular function:ribosome binding
GO:0000027; Biological process:ribosomal large subunit assembly

Cross-references [?]

PROSITE PS00301; G_TR_1; 1;
PROSITE PS51722; G_TR_2; 1;
Pfam PF00679; EFG_C; 1;
Pfam PF00009; GTP_EFTU; 1;
Pfam PF03144; GTP_EFTU_D2; 1;
NCBIfam TIGR00231; small_GTP; 1;
NCBIfam TIGR01394; TypA_BipA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 15 20 /ligand="GTP"
BINDING 128 131 /ligand="GTP"

Additional information [?]

Size range 575-643 amino acids
Related rules None
Fusion Nter: None Cter: None

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