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HAMAP rule MF_00851

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General rule information [?]

Accession MF_00851
Dates 31-MAR-2020 (Created)
19-NOV-2022 (Last updated, Version 5)
Name Leader_SpeFL
Scope(s) Bacteria
Template(s) P0DTV7 (SPEFL_ECOLI); P0DTV8 (SPEFL_SALTS); [ Recover all ]
Triggered by HAMAP; MF_00851 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SPEFL
Protein name RecName: Full=Leader peptide SpeFL;
AltName: Full=Arrest peptide SpeFL;
Gene name Name=speFL;

Comments [?]

FUNCTIONA small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation.
SUBUNITBinds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22.
INDUCTIONInduced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon.
SIMILARITYBelongs to the speF operon leader peptide family.

Keywords [?]

Gene Ontology [?]

GO:0006448; Biological process:regulation of translational elongation
GO:0031556; Biological process:transcriptional attenuation by ribosome

Cross-references [?]

Pfam PF10940; DUF2618; 0-1;

Features [?]

Key From To Description Tag Condition FTGroup
MOTIF 10 16 /note="Ornithine recognition loop" H-I-R-R-x-x-H
BINDING 13 13 /ligand="L-ornithine"

Additional information [?]

Size range 34-64 amino acids
Related rules None
Fusion Nter: None Cter: None

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