HAMAP rule MF_00851
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00851 |
| Accession | MF_00851 |
| Dates | 31-MAR-2020 (Created)
19-NOV-2022 (Last updated, Version 5) |
| Name | Leader_SpeFL |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0DTV7 (SPEFL_ECOLI); P0DTV8 (SPEFL_SALTS); [ Recover all ] |
| Triggered by |
HAMAP; MF_00851 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SPEFL |
| Protein name | RecName: Full=Leader peptide SpeFL; AltName: Full=Arrest peptide SpeFL; |
| Gene name | Name=speFL; |
Comments
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| FUNCTION | A small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation. |
| SUBUNIT | Binds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22. |
| INDUCTION | Induced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon. |
| SIMILARITY | Belongs to the speF operon leader peptide family. |
Keywords
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| Leader peptide |
| RNA-binding |
| Transcription |
| Transcription regulation |
| Translation regulation |
| rRNA-binding |
Gene Ontology
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| GO:0006448; Biological process:regulation of translational elongation |
| GO:0031556; Biological process:transcriptional attenuation by ribosome |
Cross-references
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| Pfam | PF10940; DUF2618; 0-1; |
Features
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| From: SPEFL_ECOLI (P0DTV7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 10 | 16 | /note="Ornithine recognition loop" | H-I-R-R-x-x-H | ||||||||
| BINDING | 13 | 13 | /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911" |
R | ||||||||
Additional information
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| Size range | 34-64 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |