HAMAP rule MF_00851
General rule information
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Accession | MF_00851 |
Dates | 31-MAR-2020 (Created) 19-NOV-2022 (Last updated, Version 5) |
Name | Leader_SpeFL |
Scope | Bacteria; Gammaproteobacteria |
Templates | P0DTV7 (SPEFL_ECOLI); P0DTV8 (SPEFL_SALTS): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | A small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation. |
Subunit | Binds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22. |
Induction | Induced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon. |
Similarity | Belongs to the speF operon leader peptide family. |
Keywords
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Leader peptide
RNA-binding
Transcription
Transcription regulation
Translation regulation
rRNA-binding
RNA-binding
Transcription
Transcription regulation
Translation regulation
rRNA-binding
Gene Ontology
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GO:0006448; Biological process: regulation of translational elongation.
GO:0031556; Biological process: transcriptional attenuation by ribosome.
GO:0031556; Biological process: transcriptional attenuation by ribosome.
Cross-references
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Pfam | PF10940; DUF2618; 0-1; |
Features
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From: SPEFL_ECOLI (P0DTV7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 10 | 16 | Ornithine recognition loop | H-I-R-R-x-x-H | ||||||||
BINDING | 13 | 13 | /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911 | R |
Additional information
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Size range | 34-64 amino acids |
Related rules | None |
Fusion | None |