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HAMAP rule MF_00851

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General rule information [?]

Accession MF_00851
Dates 31-MAR-2020 (Created)
19-NOV-2022 (Last updated, Version 5)
Name Leader_SpeFL
Bacteria; Gammaproteobacteria
Templates P0DTV7 (SPEFL_ECOLI); P0DTV8 (SPEFL_SALTS): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Leader peptide SpeFL;
AltName: Full=Arrest peptide SpeFL;
Gene name

Comments [?]

Function A small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation.
Subunit Binds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22.
Induction Induced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon.
Similarity Belongs to the speF operon leader peptide family.

Keywords [?]

Gene Ontology [?]

GO:0006448; Biological process: regulation of translational elongation.
GO:0031556; Biological process: transcriptional attenuation by ribosome.

Cross-references [?]

Pfam PF10940; DUF2618; 0-1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     10     16       Ornithine recognition loop     H-I-R-R-x-x-H  
BINDING     13     13       /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911     R  

Additional information [?]

Size range 34-64 amino acids
Related rules None
Fusion None