HAMAP rule MF_00851

General rule information [?]

Accession	MF_00851
Dates	31-MAR-2020 (Created) 19-NOV-2022 (Last updated, Version 5)

Name	Leader_SpeFL

Scope

Bacteria; Gammaproteobacteria

Templates

P0DTV7 (SPEFL_ECOLI); P0DTV8 (SPEFL_SALTS): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SPEFL

Protein name

RecName:		Full=Leader peptide SpeFL;
AltName:		Full=Arrest peptide SpeFL;

Gene name

speFL

Comments [?]

Function	A small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (usually speF and potE) by transcriptional and translational attenuation.
Subunit	Binds ornithine in stalled 70S ribosomes, blocking the upper two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins L4 and L22.
Induction	Induced by ornithine, repressed by putrescine. Part of the speFL-speF-potE operon.
Similarity	Belongs to the speF operon leader peptide family.

Keywords [?]

Gene Ontology [?]

GO:0006448; Biological process: regulation of translational elongation.
GO:0031556; Biological process: transcriptional attenuation by ribosome.

Cross-references [?]

Pfam	PF10940; DUF2618; 0-1;

Features [?]

From: SPEFL_ECOLI (P0DTV7)

Key From To Description Tag Condition FTGroup

MOTIF 10 16 Ornithine recognition loop H-I-R-R-x-x-H

BINDING 13 13 /ligand="L-ornithine" /ligand_id="ChEBI:CHEBI:46911 R

Additional information [?]