HAMAP rule MF_00853
General rule information
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Accession | MF_00853 |
Dates | 12-MAY-2020 (Created)
25-AUG-2020 (Last updated, Version 3) |
Name | HemG |
Scope(s) |
Bacteria |
Template(s) | P0ACB4 (HEMG_ECOLI); Q4QIU7 (HEMG_LEIMA); [ Recover all ] |
Triggered by |
HAMAP; MF_00853 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HEMG |
Protein name | RecName: Full=Protoporphyrinogen IX dehydrogenase [quinone]; EC=1.3.5.3; AltName: Full=Protoporphyrinogen IX dehydrogenase [menaquinone]; AltName: Full=Protoporphyrinogen IX dehydrogenase [ubiquinone]; AltName: Full=Protoporphyrinogen oxidase; Short=PPO; |
Gene name | Name=hemG; |
Comments
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FUNCTION | Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor. |
CATALYTIC ACTIVITY | Reaction=3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX; Xref=Rhea:RHEA:65032, ChEBI:CHEBI:24646, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307, ChEBI:CHEBI:132124; EC=1.3.5.3; |
CATALYTIC ACTIVITY | Reaction=3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX; Xref=Rhea:RHEA:27409, Rhea:RHEA-COMP:9537, Rhea:RHEA-COMP:9539, ChEBI:CHEBI:16374, ChEBI:CHEBI:18151, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; EC=1.3.5.3; |
CATALYTIC ACTIVITY | Reaction=3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX; Xref=Rhea:RHEA:63936, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; |
COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; Note=Binds 1 FMN non-covalently per subunit.; |
PATHWAY | Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
end case | |
SIMILARITY | Belongs to the HemG family. |
Keywords
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case <Property:Membrane=2> | |
Cell inner membrane | |
else case not defined <Property:Membrane> or <Property:Membrane=1> | |
Cell membrane | |
end case | |
FMN | |
Flavoprotein | |
Nucleotide-binding | |
Oxidoreductase | |
Porphyrin biosynthesis |
Gene Ontology
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GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process |
GO:0070819; Molecular function:menaquinone-dependent protoporphyrinogen oxidase activity |
GO:0010181; Molecular function:FMN binding |
GO:0006783; Biological process:heme biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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PROSITE | PS00201; FLAVODOXIN; 0-1; |
PROSITE | PS50902; FLAVODOXIN_LIKE; 0-1; |
Pfam | PF12724; Flavodoxin_5; 1; |
Features
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Additional information
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Size range | 163-241 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |