HAMAP rule MF_00853

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00853
Accession	MF_00853
Dates	12-MAY-2020 (Created) 03-SEP-2024 (Last updated, Version 5)
Name	HemG
Scope(s)	Bacteria
Template(s)	P0ACB4; Q4QIU7; [ Recover all ]
Triggered by	HAMAP; MF_00853 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HEMG
Protein name	RecName: Full=Protoporphyrinogen IX dehydrogenase [quinone]; EC=1.3.5.3; AltName: Full=Protoporphyrinogen IX dehydrogenase [menaquinone]; AltName: Full=Protoporphyrinogen IX dehydrogenase [ubiquinone]; AltName: Full=Protoporphyrinogen oxidase; Short=PPO;
Gene name	Name=hemG;

Comments [?]

FUNCTION	Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
CATALYTIC ACTIVITY	Reaction=protoporphyrinogen IX + 3 a quinone = protoporphyrin IX + 3 a quinol; Xref=Rhea:RHEA:65032, ChEBI:CHEBI:24646, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307, ChEBI:CHEBI:132124; EC=1.3.5.3;
CATALYTIC ACTIVITY	Reaction=protoporphyrinogen IX + 3 a menaquinone = protoporphyrin IX + 3 a menaquinol; Xref=Rhea:RHEA:27409, Rhea:RHEA-COMP:9537, Rhea:RHEA-COMP:9539, ChEBI:CHEBI:16374, ChEBI:CHEBI:18151, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; EC=1.3.5.3;
CATALYTIC ACTIVITY	Reaction=protoporphyrinogen IX + 3 a ubiquinone = protoporphyrin IX + 3 a ubiquinol; Xref=Rhea:RHEA:63936, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307;
COFACTOR	Name=FMN; Xref=ChEBI:CHEBI:58210; Note=Binds 1 FMN non-covalently per subunit.;
PATHWAY	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Peripheral membrane protein.
end case
SIMILARITY	Belongs to the HemG family.

Keywords [?]

case <Property:Membrane=2>
Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
Cell membrane
end case
FMN
Flavoprotein
Nucleotide-binding
Oxidoreductase
Porphyrin biosynthesis

Gene Ontology [?]

GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process

GO:0070819; Molecular function:menaquinone-dependent protoporphyrinogen oxidase activity

GO:0010181; Molecular function:FMN binding

GO:0006783; Biological process:heme biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]