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HAMAP rule MF_00853

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General rule information [?]

Accession MF_00853
Dates 12-MAY-2020 (Created)
25-AUG-2020 (Last updated, Version 3)
Name HemG
Scope
Bacteria
Templates P0ACB4 (HEMG_ECOLI); Q4QIU7 (HEMG_LEIMA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HEMG
Protein name
RecName: Full=Protoporphyrinogen IX dehydrogenase [quinone];
EC 1.3.5.3;
AltName: Full=Protoporphyrinogen IX dehydrogenase [menaquinone];
AltName: Full=Protoporphyrinogen IX dehydrogenase [ubiquinone];
AltName: Full=Protoporphyrinogen oxidase;
Short=PPO;
Gene name
hemG

Comments [?]

Function Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
Catalytic activity RHEA:65032: 3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX
EC 1.3.5.3
RHEA:27409: 3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX
EC 1.3.5.3
RHEA:63936: 3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX
Cofactor FMN
Note: Binds 1 FMN non-covalently per subunit.
Pathway Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the HemG family.

Keywords [?]

case <Property:Membrane=2>
Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
Cell membrane
end case
FMN
Flavoprotein
Nucleotide-binding
Oxidoreductase
Porphyrin biosynthesis

Gene Ontology [?]

GO:0006782; Biological process: protoporphyrinogen IX biosynthetic process.
GO:0070819; Molecular function: menaquinone-dependent protoporphyrinogen oxidase activity.
GO:0010181; Molecular function: FMN binding.
GO:0006783; Biological process: heme biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS00201; FLAVODOXIN; 0-1;
PS50902; FLAVODOXIN_LIKE; 0-1; trigger=PRU00088;
Pfam PF12724; Flavodoxin_5; 1;

Additional information [?]

Size range 163-241 amino acids
Related rules None
Fusion None


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