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HAMAP rule MF_00853

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General rule information [?]

Accession MF_00853
Dates 12-MAY-2020 (Created)
25-AUG-2020 (Last updated, Version 3)
Name HemG
Scope(s) Bacteria
Template(s) P0ACB4 (HEMG_ECOLI); Q4QIU7 (HEMG_LEIMA); [ Recover all ]
Triggered by HAMAP; MF_00853 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HEMG
Protein name RecName: Full=Protoporphyrinogen IX dehydrogenase [quinone];
                 EC=1.3.5.3;
AltName: Full=Protoporphyrinogen IX dehydrogenase [menaquinone];
AltName: Full=Protoporphyrinogen IX dehydrogenase [ubiquinone];
AltName: Full=Protoporphyrinogen oxidase;
                 Short=PPO;
Gene name Name=hemG;

Comments [?]

FUNCTIONCatalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
CATALYTIC ACTIVITY Reaction=3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX; Xref=Rhea:RHEA:65032, ChEBI:CHEBI:24646, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307, ChEBI:CHEBI:132124; EC=1.3.5.3;
CATALYTIC ACTIVITY Reaction=3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX; Xref=Rhea:RHEA:27409, Rhea:RHEA-COMP:9537, Rhea:RHEA-COMP:9539, ChEBI:CHEBI:16374, ChEBI:CHEBI:18151, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; EC=1.3.5.3;
CATALYTIC ACTIVITY Reaction=3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX; Xref=Rhea:RHEA:63936, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57306, ChEBI:CHEBI:57307;
COFACTOR Name=FMN; Xref=ChEBI:CHEBI:58210; Note=Binds 1 FMN non-covalently per subunit.;
PATHWAYPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein.
end case
SIMILARITYBelongs to the HemG family.

Keywords [?]

case <Property:Membrane=2>
Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
Cell membrane
end case
FMN
Flavoprotein
Nucleotide-binding
Oxidoreductase
Porphyrin biosynthesis

Gene Ontology [?]

GO:0006782; Biological process:protoporphyrinogen IX biosynthetic process
GO:0070819; Molecular function:menaquinone-dependent protoporphyrinogen oxidase activity
GO:0010181; Molecular function:FMN binding
GO:0006783; Biological process:heme biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

PROSITE PS00201; FLAVODOXIN; 0-1;
PROSITE PS50902; FLAVODOXIN_LIKE; 0-1;
Pfam PF12724; Flavodoxin_5; 1;

Features [?]


Additional information [?]

Size range 163-241 amino acids
Related rules None
Fusion Nter: None Cter: None



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