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HAMAP rule MF_00868

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General rule information [?]

Accession MF_00868
Dates 10-JUN-2022 (Created)
13-JAN-2023 (Last updated, Version 4)
Name Cds1
Scope(s) Bacteria
Template(s) O69652 (CDS1_MYCTU); A5U908 (CDS1_MYCTA); [ Recover all ]
Triggered by HAMAP; MF_00868 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CDS1
Protein name RecName: Full=L-cysteine desulfhydrase Cds1;
                 EC=4.4.1.1;
Gene name Name=cds1;

Comments [?]

case <OC:Actinomycetota>
FUNCTIONA cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme modulates the balance between respiration and glycolysis, and contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress).
else
FUNCTIONA cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme may modulate central metabolism.
end case
CATALYTIC ACTIVITY Reaction=H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate; Xref=Rhea:RHEA:24931, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:29919, ChEBI:CHEBI:35235; EC=4.4.1.1; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24932;
case <FT:1>
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
end case
SIMILARITYBelongs to the cysteine synthase/cystathionine beta- synthase family. Cds1 subfamily.

Keywords [?]

Cytoplasm
Lyase
case <FT:1>
Pyridoxal phosphate
end case

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0019450; Biological process:L-cysteine catabolic process to pyruvate

Cross-references [?]

Pfam PF00291; PALP; 1;

Features [?]

From: CDS1_MYCTU (O69652)
Key From To Description Tag Condition FTGroup
MOD_RES 67 67 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 340-440 amino acids
Related rules None
Fusion Nter: None Cter: None



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