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Annotation rule MF_00868
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General rule information [?]

Accession MF_00868
Dates 10-JUN-2022 (Created)
13-JAN-2023 (Last updated, Version 4)
Name Cds1
Scope
Bacteria
Templates O69652 (CDS1_MYCTU); A5U908 (CDS1_MYCTA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CDS1
Protein name
RecName: Full=L-cysteine desulfhydrase Cds1;
EC 4.4.1.1;
Gene name
cds1

Comments [?]

case <OC:Actinomycetota>
Function A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme modulates the balance between respiration and glycolysis, and contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress).
else
Function A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme may modulate central metabolism.
end case
Catalytic activity RHEA:24931: H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate
EC 4.4.1.1
PhysiologicalDirection=left-to-right (RHEA:24932)
case <FT:1>
Cofactor pyridoxal 5'-phosphate
end case
Similarity Belongs to the cysteine synthase/cystathionine beta-synthase family. Cds1 subfamily.

Keywords [?]

Cytoplasm
Lyase
case <FT:1>
Pyridoxal phosphate
end case

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0019450; Biological process: L-cysteine catabolic process to pyruvate.

Cross-references [?]

Pfam PF00291; PALP; 1;

Features [?]

From: CDS1_MYCTU (O69652)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     67     67       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 340-440 amino acids
Related rules None
Fusion None


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