HAMAP rule MF_00868
General rule information
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| Accession | MF_00868 |
| Dates | 10-JUN-2022 (Created) 13-JAN-2023 (Last updated, Version 4) |
| Name | Cds1 |
| Scope | Bacteria |
| Templates | O69652 (CDS1_MYCTU); A5U908 (CDS1_MYCTA): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Actinomycetota>
| Function | A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme modulates the balance between respiration and glycolysis, and contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress). |
else
| Function | A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme may modulate central metabolism. |
end case
| Catalytic activity | RHEA:24931: H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate
EC 4.4.1.1 PhysiologicalDirection=left-to-right (RHEA:24932) |
case <FT:1>
| Cofactor | pyridoxal 5'-phosphate |
end case
| Similarity | Belongs to the cysteine synthase/cystathionine beta-synthase family. Cds1 subfamily. |
Keywords
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case <FT:1>
end case
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0019450; Biological process: L-cysteine catabolic process to pyruvate.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0019450; Biological process: L-cysteine catabolic process to pyruvate.
Cross-references
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| Pfam | PF00291; PALP; 1; |
Features
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| From: CDS1_MYCTU (O69652) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 67 | 67 | N6-(pyridoxal phosphate)lysine | K | ||||||||
Additional information
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| Size range | 340-440 amino acids |
| Related rules | None |
| Fusion | None |