HAMAP rule MF_00901
General rule information
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Accession | MF_00901 |
Dates | 8-JUL-2011 (Created) 7-FEB-2023 (Last updated, Version 11) |
Name | TatD_exonuclease |
Scope | Bacteria; Enterobacterales |
Template | P27859 (TATD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. |
Cofactor | Mg(2+) |
Subunit | Monomer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily. |
Keywords
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Gene Ontology
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GO:0008310; Molecular function: single-stranded DNA 3'-5' DNA exonuclease activity.
GO:0000175; Molecular function: 3'-5'-RNA exonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0005737; Cellular component: cytoplasm.
GO:0000175; Molecular function: 3'-5'-RNA exonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS01137; TATD_1; 1; |
PS01090; TATD_2; 1; | |
PS01091; TATD_3; 1; | |
Pfam | PF01026; TatD_DNase; 1; |
PIRSF | PIRSF005902; DNase_TatD; 1; |
Features
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From: TATD_ECOLI (P27859) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 91 | 91 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | E | ||||||||
BINDING | 127 | 127 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | H | ||||||||
BINDING | 152 | 152 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 | H |
Additional information
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Size range | 255-290 amino acids |
Related rules | None |
Fusion | None |
Comments | The family is restricted to Enterobacterales in order to avoid wrong matches. |