HAMAP rule MF_00901
General rule information
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| Accession | MF_00901 |
| Dates | 8-JUL-2011 (Created)
7-FEB-2023 (Last updated, Version 11) |
| Name | TatD_exonuclease |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P27859 (TATD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00901 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TATD |
| Protein name | RecName: Full=3'-5' ssDNA/RNA exonuclease TatD; EC=3.1.11.-; EC=3.1.13.-; AltName: Full=DNase TatD; |
| Gene name | Name=tatD; |
Comments
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| FUNCTION | 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily. |
Keywords
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Gene Ontology
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| GO:0008310; Molecular function:single-stranded DNA 3'-5' DNA exonuclease activity |
| GO:0000175; Molecular function:3'-5'-RNA exonuclease activity |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0090305; Biological process:nucleic acid phosphodiester bond hydrolysis |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS01137; TATD_1; 1; |
| PROSITE | PS01090; TATD_2; 1; |
| PROSITE | PS01091; TATD_3; 1; |
| Pfam | PF01026; TatD_DNase; 1; |
| PIRSF | PIRSF005902; DNase_TatD; 1; |
Features
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| From: TATD_ECOLI (P27859) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 91 | 91 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | ||||||||
| BINDING | 127 | 127 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | ||||||||
| BINDING | 152 | 152 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
H | ||||||||
Additional information
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| Size range | 255-290 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The family is restricted to Enterobacterales in order to avoid wrong matches. |