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HAMAP rule MF_00901

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General rule information [?]

Accession MF_00901
Dates 8-JUL-2011 (Created)
7-FEB-2023 (Last updated, Version 11)
Name TatD_exonuclease
Bacteria; Enterobacterales
Template P27859 (TATD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3'-5' ssDNA/RNA exonuclease TatD;
EC 3.1.11.-;
EC 3.1.13.-;
AltName: Full=DNase TatD;
Gene name

Comments [?]

Function 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair.
Cofactor Mg(2+)
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008310; Molecular function: single-stranded DNA 3'-5' DNA exonuclease activity.
GO:0000175; Molecular function: 3'-5'-RNA exonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS01137; TATD_1; 1;
PS01090; TATD_2; 1;
PS01091; TATD_3; 1;
Pfam PF01026; TatD_DNase; 1;
PIRSF PIRSF005902; DNase_TatD; 1;

Features [?]

From: TATD_ECOLI (P27859)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     91     91       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     E  
BINDING     127     127       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     H  
BINDING     152     152       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240     H  

Additional information [?]

Size range 255-290 amino acids
Related rules None
Fusion None
Comments The family is restricted to Enterobacterales in order to avoid wrong matches.