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HAMAP rule MF_00901

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General rule information [?]

Accession MF_00901
Dates 8-JUL-2011 (Created)
15-DEC-2023 (Last updated, Version 12)
Name TatD_exonuclease
Scope(s) Bacteria
Template(s) P27859 (TATD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00901 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TATD
Protein name RecName: Full=3'-5' ssDNA/RNA exonuclease TatD;
AltName: Full=DNase TatD;
Gene name Name=tatD;

Comments [?]

FUNCTION3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair.
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008310; Molecular function:single-stranded DNA 3'-5' DNA exonuclease activity
GO:0000175; Molecular function:3'-5'-RNA exonuclease activity
GO:0000287; Molecular function:magnesium ion binding
GO:0090304; Biological process:nucleic acid metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS01137; TATD_1; 1;
PROSITE PS01090; TATD_2; 1;
PROSITE PS01091; TATD_3; 1;
Pfam PF01026; TatD_DNase; 1;
PIRSF PIRSF005902; DNase_TatD; 1;

Features [?]

From: TATD_ECOLI (P27859)
Key From To Description Tag Condition FTGroup
BINDING 91 91 /ligand="a divalent metal cation"
BINDING 127 127 /ligand="a divalent metal cation"
BINDING 152 152 /ligand="a divalent metal cation"

Additional information [?]

Size range 255-290 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The family is restricted to Enterobacterales in order to avoid wrong matches.

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