HAMAP rule MF_00901

General rule information [?]

Accession	MF_00901
Dates	8-JUL-2011 (Created) 7-FEB-2023 (Last updated, Version 11)

Name	TatD_exonuclease

Scope

Bacteria; Enterobacterales

Template

P27859 (TATD_ECOLI)

Triggered by

HAMAP; MF_00901 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TATD

Protein name

RecName:		Full=3'-5' ssDNA/RNA exonuclease TatD;
		EC 3.1.11.-;
		EC 3.1.13.-;
AltName:		Full=DNase TatD;

Gene name

tatD

Comments [?]

Function	3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair.
Cofactor	Mg(2+)
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.

Keywords [?]

Cytoplasm
Exonuclease
Hydrolase
Magnesium
Metal-binding
Nuclease

Gene Ontology [?]

GO:0008310; Molecular function: single-stranded DNA 3'-5' DNA exonuclease activity.
GO:0000175; Molecular function: 3'-5'-RNA exonuclease activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0090305; Biological process: nucleic acid phosphodiester bond hydrolysis.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS01137; TATD_1; 1;
	PS01090; TATD_2; 1;
	PS01091; TATD_3; 1;
Pfam	PF01026; TatD_DNase; 1;
PIRSF	PIRSF005902; DNase_TatD; 1;

Features [?]

From: TATD_ECOLI (P27859)

Key From To Description Tag Condition FTGroup

BINDING 91 91 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 E

BINDING 127 127 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 H

BINDING 152 152 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240 H

Additional information [?]

Size range	255-290 amino acids
Related rules	None
Fusion	None
Comments	The family is restricted to Enterobacterales in order to avoid wrong matches.

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