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HAMAP rule MF_00905

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General rule information [?]

Accession MF_00905
Dates 17-AUG-2011 (Created)
19-NOV-2022 (Last updated, Version 12)
Name cAMP_phosphodiest_CpdA
Bacteria; Gammaproteobacteria
Templates P0AEW4 (CPDA_ECOLI); P44685 (CPDA_HAEIN); Q6XBH1 (GPDQ_KLEAE); P9WP65 (CNPD3_MYCTU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA;
Short=3',5'-cyclic AMP phosphodiesterase;
Short=cAMP phosphodiesterase;
Gene name

Comments [?]

Function Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
Catalytic activity RHEA:25277: 3',5'-cyclic AMP + H2O = AMP + H(+)
Cofactor Fe(2+)
Note: Binds 2 Fe(2+) ions per subunit.
Similarity Belongs to the cyclic nucleotide phosphodiesterase class-III family.

Keywords [?]

Gene Ontology [?]

GO:0004115; Molecular function: 3',5'-cyclic-AMP phosphodiesterase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.

Cross-references [?]

Pfam PF00149; Metallophos; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     94     95       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     N-H  
BINDING     22     22       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     D  
BINDING     24     24       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     H  
BINDING     64     64       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     D  
BINDING     64     64       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     D  
BINDING     94     94       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     N  
BINDING     164     164       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     H  
BINDING     203     203       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2     H  
BINDING     205     205       /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1     H  
BINDING     24     24       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     H  
BINDING     64     64       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     D  
BINDING     205     205       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     H  

Additional information [?]

Size range 240-320 amino acids
Related rules None
Fusion None