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Annotation rule MF_00905
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General rule information [?]

Accession MF_00905
Dates 17-AUG-2011 (Created)
2-MAR-2021 (Last updated, Version 9)
Name cAMP_phosphodiest_CpdA
Scope
Bacteria
Templates P9WP65 (CPDA_MYCTU); P0AEW4 (CPDA_ECOLI); D4P095 (CPDA_PSEAI); Q8YLG0 (CPDA_NOSS1); P44685 (CPDA_HAEIN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CPDA
Protein name
RecName: Full=3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA;
Short=3',5'-cyclic AMP phosphodiesterase;
Short=cAMP phosphodiesterase;
EC 3.1.4.53;
Gene name
cpdA

Comments [?]

Function Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
Catalytic activity RHEA:25277: 3',5'-cyclic AMP + H2O = AMP + H(+)
EC 3.1.4.53
Cofactor Fe(2+)
Note: Binds 2 Fe(2+) ions per subunit.
Similarity Belongs to the cAMP phosphodiesterase class-III family.

Keywords [?]

cAMP
Hydrolase
Iron
Metal-binding
Nucleotide-binding

Gene Ontology [?]

GO:0004115; Molecular function: 3',5'-cyclic-AMP phosphodiesterase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.

Cross-references [?]

Pfam PF00149; Metallophos; 1;

Features [?]

From: CPDA_MYCTU (P9WP65)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     97     98       3',5'-cAMP     N-H  
METAL     21     21       Iron 1     D  
METAL     23     23       Iron 1     H  
METAL     63     63       Iron 1     D  
METAL     63     63       Iron 2     D  
METAL     97     97       Iron 2     N  
METAL     169     169       Iron 2     H  
METAL     207     207       Iron 2     H  
METAL     209     209       Iron 1     H  
BINDING     23     23       3',5'-cAMP     H  
BINDING     63     63       3',5'-cAMP     D  
BINDING     209     209       3',5'-cAMP     H  

Additional information [?]

Size range 233-340 amino acids
Related rules None
Fusion None


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