HAMAP rule MF_00905
General rule information
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Accession | MF_00905 |
Dates | 17-AUG-2011 (Created) 19-NOV-2022 (Last updated, Version 12) |
Name | cAMP_phosphodiest_CpdA |
Scope | Bacteria; Gammaproteobacteria |
Templates | P0AEW4 (CPDA_ECOLI); P44685 (CPDA_HAEIN); Q6XBH1 (GPDQ_KLEAE); P9WP65 (CNPD3_MYCTU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. |
Catalytic activity | RHEA:25277: 3',5'-cyclic AMP + H2O = AMP + H(+)
EC 3.1.4.53 |
Cofactor | Fe(2+) Note: Binds 2 Fe(2+) ions per subunit. |
Similarity | Belongs to the cyclic nucleotide phosphodiesterase class-III family. |
Keywords
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Gene Ontology
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GO:0004115; Molecular function: 3',5'-cyclic-AMP phosphodiesterase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.
Cross-references
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Pfam | PF00149; Metallophos; 1; |
Features
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From: CPDA_ECOLI (P0AEW4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 94 | 95 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | N-H | ||||||||
BINDING | 22 | 22 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | D | ||||||||
BINDING | 24 | 24 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | H | ||||||||
BINDING | 64 | 64 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | D | ||||||||
BINDING | 64 | 64 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | D | ||||||||
BINDING | 94 | 94 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | N | ||||||||
BINDING | 164 | 164 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | H | ||||||||
BINDING | 203 | 203 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 | H | ||||||||
BINDING | 205 | 205 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 | H | ||||||||
BINDING | 24 | 24 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | H | ||||||||
BINDING | 64 | 64 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | D | ||||||||
BINDING | 205 | 205 | /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 | H |
Additional information
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Size range | 240-320 amino acids |
Related rules | None |
Fusion | None |