HAMAP rule MF_00905

General rule information [?]

Accession	MF_00905
Dates	17-AUG-2011 (Created) 19-NOV-2022 (Last updated, Version 12)

Name	cAMP_phosphodiest_CpdA

Scope

Bacteria; Gammaproteobacteria

Templates

P0AEW4 (CPDA_ECOLI); P44685 (CPDA_HAEIN); Q6XBH1 (GPDQ_KLEAE); P9WP65 (CNPD3_MYCTU): [Recover all]

Triggered by

HAMAP; MF_00905 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CPDA

Protein name

RecName:		Full=3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA;
		Short=3',5'-cyclic AMP phosphodiesterase;
		Short=cAMP phosphodiesterase;
		EC 3.1.4.53;

Gene name

cpdA

Comments [?]

Function	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
Catalytic activity	RHEA:25277: 3',5'-cyclic AMP + H2O = AMP + H(+) EC 3.1.4.53
Cofactor	Fe(2+) Note: Binds 2 Fe(2+) ions per subunit.
Similarity	Belongs to the cyclic nucleotide phosphodiesterase class-III family.

Keywords [?]

cAMP
Hydrolase
Iron
Metal-binding
Nucleotide-binding

Gene Ontology [?]

GO:0004115; Molecular function: 3',5'-cyclic-AMP phosphodiesterase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.

Cross-references [?]

Pfam	PF00149; Metallophos; 1;

Features [?]

From: CPDA_ECOLI (P0AEW4)

Key From To Description Tag Condition FTGroup

BINDING 94 95 /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 N-H

BINDING 22 22 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 D

BINDING 24 24 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 H

BINDING 64 64 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 D

BINDING 64 64 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 D

BINDING 94 94 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 N

BINDING 164 164 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 H

BINDING 203 203 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="2 H

BINDING 205 205 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_label="1 H

BINDING 24 24 /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 H

BINDING 64 64 /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 D

BINDING 205 205 /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215 H

Additional information [?]

Size range	240-320 amino acids
Related rules	None
Fusion	None

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