HAMAP rule MF_00908
General rule information
[?]
| Accession |
MF_00908 |
| Dates |
30-SEP-2011 (Created)
3-MAY-2022 (Last updated, Version 4) |
| Scope |
Bacteria; Gammaproteobacteria |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name |
|
RecName:
|
Full=Negative modulator of initiation of replication;
|
|
| Function |
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. |
| Subunit |
Homodimer. Polymerizes to form helical filaments. |
| Subcellular location |
Cytoplasm. |
| Similarity |
Belongs to the SeqA family. |
GO:0003677; Molecular function: DNA binding.
GO:0032297; Biological process: negative regulation of DNA-templated DNA replication initiation.
GO:0005737; Cellular component: cytoplasm.
| From: SEQA_ECOLI (P0AFY8) |
|
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
|
REGION (Optional)
|
|
87
|
|
88
|
|
Interaction with DNA
|
|
|
|
A-V
|
|
|
|
REGION (Optional)
|
|
116
|
|
120
|
|
Interaction with DNA
|
|
|
|
R-T-R-[VIL]-Y
|
|
|
|
REGION (Optional)
|
|
150
|
|
156
|
|
Interaction with DNA
|
|
|
|
N-[TS]-N-[TS]-G-[RK]-K
|
|
|
Additional information
[?]
| Size range |
149-253 amino acids |
| Related rules |
None |
| Fusion |
None |
