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Annotation rule MF_00908 |
Accession | MF_00908 |
Dates | 30-SEP-2011 (Created) 19-NOV-2019 (Last updated, Version 3) |
Name | SeqA |
Scope | Bacteria; Gammaproteobacteria |
Template | P0AFY8 (SEQA_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. |
Subunit | Homodimer. Polymerizes to form helical filaments. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the SeqA family. |
Pfam | PF03925; SeqA; 1; |
From: SEQA_ECOLI (P0AFY8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION (Optional) | 87 | 88 | Interaction with DNA | A-V | ||||||||
REGION (Optional) | 116 | 120 | Interaction with DNA | R-T-R-[VIL]-Y | ||||||||
REGION (Optional) | 150 | 156 | Interaction with DNA | N-[TS]-N-[TS]-G-[RK]-K |
Size range | 149-253 amino acids |
Related rules | None |
Fusion | None |