HAMAP logo

HAMAP rule MF_00908

Send feedback

General rule information [?]

Accession MF_00908
Dates 30-SEP-2011 (Created)
3-MAY-2022 (Last updated, Version 4)
Name SeqA
Scope(s) Bacteria
Template(s) P0AFY8 (SEQA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00908 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SEQA
Protein name RecName: Full=Negative modulator of initiation of replication;
Gene name Name=seqA;

Comments [?]

FUNCTIONNegative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
SUBUNITHomodimer. Polymerizes to form helical filaments.
SIMILARITYBelongs to the SeqA family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0032297; Biological process:negative regulation of DNA-templated DNA replication initiation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03925; SeqA; 1;

Features [?]

Key From To Description Tag Condition FTGroup
REGION 87 88 /note="Interaction with DNA" A-V
REGION 116 120 /note="Interaction with DNA" R-T-R-[VIL]-Y
REGION 150 156 /note="Interaction with DNA" N-[TS]-N-[TS]-G-[RK]-K

Additional information [?]

Size range 149-253 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)