HAMAP rule MF_00908

General rule information [?]

Accession	MF_00908
Dates	30-SEP-2011 (Created) 3-MAY-2022 (Last updated, Version 4)
Name	SeqA
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P0AFY8 (SEQA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00908 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SEQA
Protein name	RecName: Full=Negative modulator of initiation of replication;
Gene name	Name=seqA;

Comments [?]

FUNCTION	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
SUBUNIT	Homodimer. Polymerizes to form helical filaments.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the SeqA family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding

GO:0032297; Biological process:negative regulation of DNA-templated DNA replication initiation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF03925; SeqA; 1;

Features [?]

From: SEQA_ECOLI (P0AFY8)

Key

From

Description

Tag

Condition

FTGroup

REGION

/note="Interaction with DNA"

A-V

REGION

116

120

/note="Interaction with DNA"

R-T-R-[VIL]-Y

REGION

150

156

/note="Interaction with DNA"

N-[TS]-N-[TS]-G-[RK]-K

Additional information [?]