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Annotation rule MF_00908
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General rule information [?]

Accession MF_00908
Dates 30-SEP-2011 (Created)
19-NOV-2019 (Last updated, Version 3)
Name SeqA
Scope
Bacteria; Gammaproteobacteria
Template P0AFY8 (SEQA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SEQA
Protein name
RecName: Full=Negative modulator of initiation of replication;
Gene name
seqA

Comments [?]

Function Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Subunit Homodimer. Polymerizes to form helical filaments.
Subcellular location Cytoplasm.
Similarity Belongs to the SeqA family.

Keywords [?]

Cytoplasm
DNA replication inhibitor
DNA-binding

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0032297; Biological process: negative regulation of DNA-dependent DNA replication initiation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03925; SeqA; 1;

Features [?]

From: SEQA_ECOLI (P0AFY8)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     87     88       Interaction with DNA     A-V  
REGION (Optional)     116     120       Interaction with DNA     R-T-R-[VIL]-Y  
REGION (Optional)     150     156       Interaction with DNA     N-[TS]-N-[TS]-G-[RK]-K  

Additional information [?]

Size range 149-253 amino acids
Related rules None
Fusion None


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