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Annotation rule MF_00913
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General rule information [?]

Accession MF_00913
Dates 23-NOV-2011 (Created)
19-NOV-2019 (Last updated, Version 11)
Name PGT_FtsW_proteobact
Scope
Bacteria; Proteobacteria
Templates P0ABG4 (FTSW_ECOLI); P0ABG7 (RODA_ECOLI): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FTSW
Protein name
RecName: Full=Probable peptidoglycan glycosyltransferase FtsW;
Short=PGT;
EC 2.4.1.129;
AltName: Full=Cell division protein FtsW;
AltName: Full=Cell wall polymerase;
AltName: Full=Peptidoglycan polymerase;
Short=PG polymerase;
Gene name
ftsW

Comments [?]

Function Peptidoglycan polymerase that is essential for cell division.
Catalytic activity RHEA:23708: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphospho-di-trans,octa-cis-undecaprenol + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphospho-di-trans-octa-cis-undecaprenol + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
EC 2.4.1.129
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Similarity Belongs to the SEDS family. FtsW subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008955; Molecular function: peptidoglycan glycosyltransferase activity.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0032153; Cellular component: cell division site.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

PROSITE PS00428; FTSW_RODA_SPOVE; 1;
Pfam PF01098; FTSW_RODA_SPOVE; 1;
TIGRFAMs TIGR02614; FtsW; 1;

Computed features [?]

General Transmembrane; -; 8-10; trigger=yes;

Additional information [?]

Size range 353-524 amino acids
Related rules None
Fusion None
Comments The HAMAP profile and rule are restricted to Betaproteobacteria and Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL.