HAMAP rule MF_00913

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00913
Accession	MF_00913
Dates	23-NOV-2011 (Created) 07-NOV-2024 (Last updated, Version 18)
Name	PGT_FtsW_proteobact
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0ABG4; P0ABG7; [ Recover all ]
Triggered by	HAMAP; MF_00913 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	FTSW
Protein name	RecName: Full=Probable peptidoglycan glycosyltransferase FtsW; Short=PGT; EC=2.4.99.28; AltName: Full=Cell division protein FtsW; AltName: Full=Cell wall polymerase; AltName: Full=Peptidoglycan polymerase; Short=PG polymerase;
Gene name	Name=ftsW;

Comments [?]

FUNCTION	Peptidoglycan polymerase that is essential for cell division.
CATALYTIC ACTIVITY	Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.99.28;
PATHWAY	Cell wall biogenesis; peptidoglycan biosynthesis.
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
SIMILARITY	Belongs to the SEDS family. FtsW subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity

GO:0043093; Biological process:FtsZ-dependent cytokinesis

GO:0009252; Biological process:peptidoglycan biosynthetic process

GO:0032153; Cellular component:cell division site

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]

Size range	353-524 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	The HAMAP profile and rule are restricted to Betaproteobacteria and Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL.