HAMAP rule MF_00913

General rule information [?]

Accession	MF_00913
Dates	23-NOV-2011 (Created) 1-JUN-2023 (Last updated, Version 15)

Name	PGT_FtsW_proteobact

Scope

Bacteria; Pseudomonadota

Templates

P0ABG4 (FTSW_ECOLI); P0ABG7 (RODA_ECOLI): [Recover all]

Triggered by

HAMAP; MF_00913 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FTSW

Protein name

RecName:		Full=Probable peptidoglycan glycosyltransferase FtsW;
		Short=PGT;
		EC 2.4.1.129;
AltName:		Full=Cell division protein FtsW;
AltName:		Full=Cell wall polymerase;
AltName:		Full=Peptidoglycan polymerase;
		Short=PG polymerase;

Gene name

ftsW

Comments [?]

Function	Peptidoglycan polymerase that is essential for cell division.
Catalytic activity	RHEA:23708: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) EC 2.4.1.129
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location	Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
Similarity	Belongs to the SEDS family. FtsW subfamily.

Keywords [?]

Cell cycle
Cell division
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Membrane
Peptidoglycan synthesis
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008955; Molecular function: peptidoglycan glycosyltransferase activity.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0032153; Cellular component: cell division site.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE	PS00428; FTSW_RODA_SPOVE; 1;
Pfam	PF01098; FTSW_RODA_SPOVE; 1;
NCBIfam	TIGR02614; FtsW; 1;

Computed features [?]

General

Transmembrane; -; 8-10; trigger=yes;

Additional information [?]

Size range	353-524 amino acids
Related rules	None
Fusion	None
Comments	The HAMAP profile and rule are restricted to Betaproteobacteria and Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL.

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