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HAMAP rule MF_00913

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General rule information [?]

Accession MF_00913
Dates 23-NOV-2011 (Created)
22-FEB-2024 (Last updated, Version 16)
Name PGT_FtsW_proteobact
Scope(s) Bacteria
Template(s) P0ABG4 (FTSW_ECOLI); P0ABG7 (RODA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00913 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FTSW
Protein name RecName: Full=Probable peptidoglycan glycosyltransferase FtsW;
AltName: Full=Cell division protein FtsW;
AltName: Full=Cell wall polymerase;
AltName: Full=Peptidoglycan polymerase;
                 Short=PG polymerase;
Gene name Name=ftsW;

Comments [?]

FUNCTIONPeptidoglycan polymerase that is essential for cell division.
CATALYTIC ACTIVITY Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum.
SIMILARITYBelongs to the SEDS family. FtsW subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity
GO:0043093; Biological process:FtsZ-dependent cytokinesis
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0032153; Cellular component:cell division site
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01098; FTSW_RODA_SPOVE; 1;
NCBIfam TIGR02614; FtsW; 1;
General Transmembrane; -; 8-10;

Features [?]

Additional information [?]

Size range 353-524 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The HAMAP profile and rule are restricted to Betaproteobacteria and Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL.

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