HAMAP rule MF_00913
General rule information
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Accession | MF_00913 |
Dates | 23-NOV-2011 (Created) 26-JAN-2023 (Last updated, Version 14) |
Name | PGT_FtsW_proteobact |
Scope | Bacteria; Pseudomonadota |
Templates | P0ABG4 (FTSW_ECOLI); P0ABG7 (RODA_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Peptidoglycan polymerase that is essential for cell division. |
Catalytic activity | RHEA:23708: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
EC 2.4.1.129 |
Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. |
Subcellular location | Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the division septum. |
Similarity | Belongs to the SEDS family. FtsW subfamily. |
Keywords
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Cell cycle
Cell division
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Membrane
Peptidoglycan synthesis
Transferase
Transmembrane
Transmembrane helix
Cell division
Cell inner membrane
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Membrane
Peptidoglycan synthesis
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0008955; Molecular function: peptidoglycan glycosyltransferase activity.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0032153; Cellular component: cell division site.
GO:0005886; Cellular component: plasma membrane.
GO:0043093; Biological process: FtsZ-dependent cytokinesis.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0032153; Cellular component: cell division site.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 8-10; trigger=yes; |
Additional information
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Size range | 353-524 amino acids |
Related rules | None |
Fusion | None |
Comments | The HAMAP profile and rule are restricted to Betaproteobacteria and Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL. |