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Annotation rule MF_00916
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General rule information [?]

Accession MF_00916
Dates 6-FEB-2012 (Created)
27-OCT-2018 (Last updated, Version 5)
Name QueG
Scope
Bacteria
Templates P97030 (QUEG_BACSU); P39288 (QUEG_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
QUEG
Protein name
RecName: Full=Epoxyqueuosine reductase;
EC=1.17.99.6;
AltName: Full=Queuosine biosynthesis protein QueG;
Gene name
queG

Comments [?]

Function Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
Catalytic activity Reaction=AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA; Xref=Rhea:RHEA:32159, Rhea:RHEA- COMP:10345, Rhea:RHEA-COMP:10346, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:82831, ChEBI:CHEBI:82834; EC=1.17.99.6;.
Pathway tRNA modification; tRNA-queuosine biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the QueG family.

Keywords [?]

4Fe-4S
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Oxidoreductase
Queuosine biosynthesis
tRNA processing

Gene Ontology [?]

GO:0052693; Molecular function: epoxyqueuosine reductase activity.
GO:0051536; Molecular function: iron-sulfur cluster binding.
GO:0008616; Biological process: queuosine biosynthetic process.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00198; 4FE4S_FER_1; 1;
PS51379; 4FE4S_FER_2; 1-2; trigger=PRU00711;
Pfam PF08331; DUF1730; 1;
PF03130; HEAT_PBS; 0-1; trigger=Yes;
TIGRFAMs TIGR00276; TIGR00276; 1;

Features [?]

From: QUEG_ECOLI (P39288)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     193     193       Iron-sulfur 1 (4Fe-4S)     C  
METAL     196     196       Iron-sulfur 1 (4Fe-4S)     C  
METAL     199     199       Iron-sulfur 1 (4Fe-4S)     C  
METAL     203     203       Iron-sulfur 2     C  
METAL     246     246       Iron-sulfur 2     C  
METAL     249     249       Iron-sulfur 2     C  
METAL     253     253       Iron-sulfur 1 (4Fe-4S)     C  

Additional information [?]

Size range 289-411 amino acids
Related rules None
Fusion None


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