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| Annotation rule MF_00916 |
General rule information
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| Accession | MF_00916 |
| Dates | 6-FEB-2012 (Created) 19-NOV-2019 (Last updated, Version 6) |
| Name | QueG |
| Scope | Bacteria |
| Templates | P97030 (QUEG_BACSU); P39288 (QUEG_ECOLI): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). |
| Catalytic activity | RHEA:32159: AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA
EC 1.17.99.6 |
| Pathway | tRNA modification; tRNA-queuosine biosynthesis. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the QueG family. |
Keywords
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4Fe-4S
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Oxidoreductase
Queuosine biosynthesis
tRNA processing
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Oxidoreductase
Queuosine biosynthesis
tRNA processing
Gene Ontology
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GO:0052693; Molecular function: epoxyqueuosine reductase activity.
GO:0051536; Molecular function: iron-sulfur cluster binding.
GO:0008616; Biological process: queuosine biosynthetic process.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.
GO:0051536; Molecular function: iron-sulfur cluster binding.
GO:0008616; Biological process: queuosine biosynthetic process.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| PROSITE | PS00198; 4FE4S_FER_1; 1; |
| PS51379; 4FE4S_FER_2; 1-2; trigger=PRU00711; | |
| Pfam | PF08331; DUF1730; 1; |
| PF03130; HEAT_PBS; 0-1; trigger=Yes; | |
| TIGRFAMs | TIGR00276; TIGR00276; 1; |
Features
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| From: QUEG_ECOLI (P39288) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| METAL | 193 | 193 | Iron-sulfur 1 (4Fe-4S) | C | ||||||||
| METAL | 196 | 196 | Iron-sulfur 1 (4Fe-4S) | C | ||||||||
| METAL | 199 | 199 | Iron-sulfur 1 (4Fe-4S) | C | ||||||||
| METAL | 203 | 203 | Iron-sulfur 2 | C | ||||||||
| METAL | 246 | 246 | Iron-sulfur 2 | C | ||||||||
| METAL | 249 | 249 | Iron-sulfur 2 | C | ||||||||
| METAL | 253 | 253 | Iron-sulfur 1 (4Fe-4S) | C | ||||||||
Additional information
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| Size range | 289-411 amino acids |
| Related rules | None |
| Fusion | None |