HAMAP rule MF_00934

General rule information [?]

Accession	MF_00934
Dates	17-JAN-2013 (Created) 19-NOV-2022 (Last updated, Version 9)

Name	23SrRNA_methyltr_J

Scope

Bacteria

Template

P37634 (RLMJ_ECOLI)

Triggered by

HAMAP; MF_00934 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RLMJ

Protein name

RecName:		Full=Ribosomal RNA large subunit methyltransferase J;
		EC 2.1.1.266;
AltName:		Full=23S rRNA (adenine(2030)-N6)-methyltransferase;
AltName:		Full=23S rRNA m6A2030 methyltransferase;

Gene name

rlmJ

Comments [?]

Function	Specifically methylates the adenine in position 2030 of 23S rRNA.
Catalytic activity	RHEA:43736: adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine EC 2.1.1.266
Subunit	Monomer.
Similarity	Belongs to the RlmJ family.

Keywords [?]

Methyltransferase
RNA-binding
rRNA processing
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0036307; Molecular function: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity.
GO:0003723; Molecular function: RNA binding.
GO:0070475; Biological process: rRNA base methylation.

Cross-references [?]

PROSITE	PS00092; N6_MTASE; 2;
Pfam	PF04378; DUF519; 1;

Features [?]

From: RLMJ_ECOLI (P37634)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 143 144 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [DNE]-[GAS]

ACT_SITE 164 164 Proton acceptor D

BINDING 19 19 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 H

BINDING 42 42 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [HYFN]

BINDING 100 100 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 S

BINDING 118 118 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [ED]

BINDING 164 164 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

SITE 4 4 Interaction with substrate rRNA Y

Additional information [?]

Size range	240-362 amino acids
Related rules	None
Fusion	None

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