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Annotation rule MF_00935
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General rule information [?]

Accession MF_00935
Dates 18-JAN-2013 (Created)
19-NOV-2019 (Last updated, Version 5)
Name AlaDH_arch
Scope
Archaea
Bacteria
Template O28608 (ALADH_ARCFU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ALADH
case <OC:Archaea>
Protein name
RecName: Full=Alanine dehydrogenase;
Short=AlaDH;
EC 1.4.1.1;
Gene name
ala
else case <OC:Bacteria>
Protein name
RecName: Full=Putative alanine dehydrogenase;
Short=AlaDH;
EC 1.4.1.1;
end case

Comments [?]

Function Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
Catalytic activity RHEA:18405: H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate
EC 1.4.1.1
Similarity Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000286; Molecular function: alanine dehydrogenase activity.
GO:0051287; Molecular function: NAD binding.
GO:0006522; Biological process: alanine metabolic process.

Cross-references [?]

Pfam PF02423; OCD_Mu_crystall; 1;
TIGRFAMs TIGR02371; ala_DH_arch; 1;
PIRSF PIRSF001439; CryM; 1;

Features [?]

From: ALADH_ARCFU (O28608)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     135     136       NAD     x-Q  
NP_BIND (Optional)     157     159       NAD     [DN]-x-[RKH]  
NP_BIND     217     219       NAD     G-x-D  
ACT_SITE     65     65       Proton donor/acceptor     K  
BINDING     108     108       NAD     R  
BINDING     223     223       NAD     K  
BINDING     290     290       NAD     S  

Additional information [?]

Size range 291-359 amino acids
Related rules None
Fusion None