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HAMAP rule MF_00935

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General rule information [?]

Accession MF_00935
Dates 18-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 8)
Name AlaDH_arch
Scope(s) Archaea
Template(s) O28608 (ALADH_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_00935 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ALADH
case <OC:Archaea>
Protein name RecName: Full=Alanine dehydrogenase;
Gene name Name=ala;
else case <OC:Bacteria>
Protein name RecName: Full=Putative alanine dehydrogenase;
end case

Comments [?]

FUNCTIONCatalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
CATALYTIC ACTIVITY Reaction=H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate; Xref=Rhea:RHEA:18405, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:57972; EC=;
SIMILARITYBelongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000286; Molecular function:alanine dehydrogenase activity
GO:0051287; Molecular function:NAD binding
GO:0006522; Biological process:alanine metabolic process

Cross-references [?]

Pfam PF02423; OCD_Mu_crystall; 1;
NCBIfam TIGR02371; ala_DH_arch; 1;
PIRSF PIRSF001439; CryM; 1;

Features [?]

From: ALADH_ARCFU (O28608)
Key From To Description Tag Condition FTGroup
BINDING 135 136 /ligand="NAD(+)"
BINDING 157 159 /ligand="NAD(+)"
BINDING 217 219 /ligand="NAD(+)"
ACT_SITE 65 65 /note="Proton donor/acceptor" K
BINDING 108 108 /ligand="NAD(+)"
BINDING 223 223 /ligand="NAD(+)"
BINDING 290 290 /ligand="NAD(+)"

Additional information [?]

Size range 291-359 amino acids
Related rules None
Fusion Nter: None Cter: None

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