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HAMAP rule MF_00936

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General rule information [?]

Accession MF_00936
Dates 21-JAN-2013 (Created)
10-OCT-2023 (Last updated, Version 14)
Name ParC_type1
Scope(s) Bacteria
Template(s) P0AFI2 (PARC_ECOLI); P72525 (PARC_STRPN); [ Recover all ]
Triggered by HAMAP; MF_00936 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PARC
Protein name RecName: Full=DNA topoisomerase 4 subunit A;
AltName: Full=Topoisomerase IV subunit A;
Gene name Name=parC;

Comments [?]

FUNCTIONTopoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=;
SUBUNITHeterotetramer composed of ParC and ParE.
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
SIMILARITYBelongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0007059; Biological process:chromosome segregation
GO:0006265; Biological process:DNA topological change
GO:0019897; Cellular component:extrinsic component of plasma membrane

Cross-references [?]

Pfam PF03989; DNA_gyraseA_C; 2-3;
Pfam PF00521; DNA_topoisoIV; 1;
NCBIfam TIGR01062; parC_Gneg; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 120 120 /note="O-(5'-phospho-DNA)-tyrosine intermediate" Y
SITE 39 39 /note="Interaction with DNA" K
SITE 75 75 /note="Interaction with DNA" H
SITE 77 77 /note="Interaction with DNA" H
SITE 119 119 /note="Transition state stabilizer" R

Additional information [?]

Size range 710-820 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See MF_00937 for ParC type 2 subfamily.

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