HAMAP rule MF_00936

Accession	MF_00936
Dates	21-JAN-2013 (Created) 26-JAN-2023 (Last updated, Version 12)

Name	ParC_type1

Scope

Bacteria; Pseudomonadota

Templates

P0AFI2 (PARC_ECOLI); P72525 (PARC_STRPN): [Recover all]

Triggered by

HAMAP; MF_00936 (Get profile general information and statistics)

Identifier

PARC

Protein name

RecName: Full=DNA topoisomerase 4 subunit A; EC 5.6.2.2; AltName: Full=Topoisomerase IV subunit A;

Gene name

parC

Function	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity	Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2;
Subunit	Heterotetramer composed of ParC and ParE.
Subcellular location	Cell membrane; Peripheral membrane protein.
Similarity	Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.

Cell membrane
DNA-binding
Isomerase
Membrane
Topoisomerase

GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.
GO:0019897; Cellular component: extrinsic component of plasma membrane.

Pfam	PF03989; DNA_gyraseA_C; 2-3;
	PF00521; DNA_topoisoIV; 1;
TIGRFAMs	TIGR01062; parC_Gneg; 1;

From: PARC_ECOLI (P0AFI2)

Key

From

To

Description

Tag

Condition

FTGroup

ACT_SITE

120

120

O-(5'-phospho-DNA)-tyrosine intermediate

Y

SITE (Optional)

39

39

Interaction with DNA

K

SITE (Optional)

75

75

Interaction with DNA

H

SITE (Optional)

77

77

Interaction with DNA

H

SITE

119

119

Transition state stabilizer

R

Size range	710-820 amino acids
Related rules	None
Fusion	None
Comments	See MF_00937 for ParC type 2 subfamily.

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