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Annotation rule MF_00939 |
Accession | MF_00939 |
Dates | 23-JAN-2013 (Created) 19-NOV-2019 (Last updated, Version 8) |
Name | ParE_type2 |
Scope | Bacteria; Firmicutes
Bacteria; Mollicutes |
Templates | Q59961 (PARE_STRPN); P20083 (PARE_ECOLI): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. |
Catalytic activity | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
Subunit | Heterotetramer composed of ParC and ParE. |
Similarity | Belongs to the type II topoisomerase family. ParE type 2 subfamily. |
PROSITE | PS00177; TOPOISOMERASE_II; 1; |
PS50880; TOPRIM; 1; trigger=PRU00995; | |
Pfam | PF00204; DNA_gyraseB; 1; |
PF00986; DNA_gyraseB_C; 1; | |
PF02518; HATPase_c; 1; | |
PF01751; Toprim; 1; | |
PRINTS | PR00418; TPI2FAMILY; 1; |
TIGRFAMs | TIGR01058; parE_Gpos; 1; |
From: PARE_STRPN (Q59961) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 118 | 124 | ATP | G-L-H-G-V-G-[AS] | ||||||||
BINDING (Optional) | 11 | 11 | ATP | Y | ||||||||
BINDING (Optional) | 51 | 51 | ATP | N | ||||||||
BINDING (Optional) | 78 | 78 | ATP | D | ||||||||
BINDING (Optional) | 344 | 344 | ATP | K | ||||||||
SITE (Optional) | 461 | 461 | Interaction with DNA | N | ||||||||
SITE (Optional) | 513 | 513 | Interaction with DNA | H | ||||||||
SITE (Optional) | 629 | 629 | Interaction with DNA | R |
Size range | 615-710 amino acids |
Related rules | None |
Fusion | None |
Comments | See MF_00938 for ParE type 1 subfamily. |