HAMAP rule MF_00939
General rule information
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| Accession | MF_00939 |
| Dates | 23-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | ParE_type2 |
| Scope(s) |
Bacteria Bacillota Mollicutes |
| Template(s) | Q59961 (PARE_STRPN); P20083 (PARE_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00939 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PARE |
| Protein name | RecName: Full=DNA topoisomerase 4 subunit B; EC=5.6.2.2; AltName: Full=Topoisomerase IV subunit B; |
| Gene name | Name=parE; |
Comments
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| FUNCTION | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. |
| CATALYTIC ACTIVITY | Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; |
| SUBUNIT | Heterotetramer composed of ParC and ParE. |
| SIMILARITY | Belongs to the type II topoisomerase family. ParE type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0003677; Molecular function:DNA binding |
| GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| GO:0007059; Biological process:chromosome segregation |
| GO:0006265; Biological process:DNA topological change |
Cross-references
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| PROSITE | PS00177; TOPOISOMERASE_II; 1; |
| PROSITE | PS50880; TOPRIM; 1; |
| Pfam | PF00204; DNA_gyraseB; 1; |
| Pfam | PF00986; DNA_gyraseB_C; 1; |
| Pfam | PF02518; HATPase_c; 1; |
| Pfam | PF01751; Toprim; 1; |
| PRINTS | PR00418; TPI2FAMILY; 1; |
| NCBIfam | TIGR01058; parE_Gpos; 1; |
Features
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| From: PARE_STRPN (Q59961) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 118 | 124 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-L-H-G-V-G-[AS] | ||||||||
| BINDING | 11 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
Y | ||||||||
| BINDING | 51 | 51 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| BINDING | 78 | 78 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
| BINDING | 344 | 344 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| SITE | 461 | 461 | /note="Interaction with DNA" | N | ||||||||
| SITE | 513 | 513 | /note="Interaction with DNA" | H | ||||||||
| SITE | 629 | 629 | /note="Interaction with DNA" | R | ||||||||
Additional information
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| Size range | 615-710 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | See MF_00938 for ParE type 1 subfamily. |