HAMAP rule MF_00939
General rule information
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| Accession | MF_00939 |
| Dates | 23-JAN-2013 (Created) 1-JUN-2023 (Last updated, Version 12) |
| Name | ParE_type2 |
| Scope | Bacteria; Bacillota
Bacteria; Mollicutes |
| Templates | Q59961 (PARE_STRPN); P20083 (PARE_ECOLI): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. |
| Catalytic activity | Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2; |
| Subunit | Heterotetramer composed of ParC and ParE. |
| Similarity | Belongs to the type II topoisomerase family. ParE type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.
Cross-references
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| PROSITE | PS00177; TOPOISOMERASE_II; 1; |
| PS50880; TOPRIM; 1; trigger=PRU00995; | |
| Pfam | PF00204; DNA_gyraseB; 1; |
| PF00986; DNA_gyraseB_C; 1; | |
| PF02518; HATPase_c; 1; | |
| PF01751; Toprim; 1; | |
| PRINTS | PR00418; TPI2FAMILY; 1; |
| NCBIfam | TIGR01058; parE_Gpos; 1; |
Features
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| From: PARE_STRPN (Q59961) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 118 | 124 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-L-H-G-V-G-[AS] | ||||||||
| BINDING (Optional) | 11 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | Y | ||||||||
| BINDING (Optional) | 51 | 51 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | N | ||||||||
| BINDING (Optional) | 78 | 78 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | D | ||||||||
| BINDING (Optional) | 344 | 344 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
| SITE (Optional) | 461 | 461 | Interaction with DNA | N | ||||||||
| SITE (Optional) | 513 | 513 | Interaction with DNA | H | ||||||||
| SITE (Optional) | 629 | 629 | Interaction with DNA | R | ||||||||
Additional information
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| Size range | 615-710 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | See MF_00938 for ParE type 1 subfamily. |