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HAMAP rule MF_00939

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General rule information [?]

Accession MF_00939
Dates 23-JAN-2013 (Created)
1-JUN-2023 (Last updated, Version 12)
Name ParE_type2
Scope(s) Bacteria
Bacillota
Mollicutes
Template(s) Q59961 (PARE_STRPN); P20083 (PARE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00939 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PARE
Protein name RecName: Full=DNA topoisomerase 4 subunit B;
                 EC=5.6.2.2;
AltName: Full=Topoisomerase IV subunit B;
Gene name Name=parE;

Comments [?]

FUNCTIONTopoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
CATALYTIC ACTIVITY Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2;
SUBUNITHeterotetramer composed of ParC and ParE.
SIMILARITYBelongs to the type II topoisomerase family. ParE type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0003918; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0007059; Biological process:chromosome segregation
GO:0006265; Biological process:DNA topological change

Cross-references [?]

PROSITE PS00177; TOPOISOMERASE_II; 1;
PROSITE PS50880; TOPRIM; 1;
Pfam PF00204; DNA_gyraseB; 1;
Pfam PF00986; DNA_gyraseB_C; 1;
Pfam PF02518; HATPase_c; 1;
Pfam PF01751; Toprim; 1;
PRINTS PR00418; TPI2FAMILY; 1;
NCBIfam TIGR01058; parE_Gpos; 1;

Features [?]

From: PARE_STRPN (Q59961)
Key From To Description Tag Condition FTGroup
BINDING 118 124 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-L-H-G-V-G-[AS]
BINDING 11 11 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
Y
BINDING 51 51 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
N
BINDING 78 78 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D
BINDING 344 344 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
SITE 461 461 /note="Interaction with DNA" N
SITE 513 513 /note="Interaction with DNA" H
SITE 629 629 /note="Interaction with DNA" R

Additional information [?]

Size range 615-710 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See MF_00938 for ParE type 1 subfamily.



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