Home  |  Contact
Annotation rule MF_00939
Send feedback

General rule information [?]

Accession MF_00939
Dates 23-JAN-2013 (Created)
19-NOV-2019 (Last updated, Version 8)
Name ParE_type2
Scope
Bacteria; Firmicutes
Bacteria; Mollicutes
Templates Q59961 (PARE_STRPN); P20083 (PARE_ECOLI): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PARE
Protein name
RecName: Full=DNA topoisomerase 4 subunit B;
EC 5.6.2.2;
AltName: Full=Topoisomerase IV subunit B;
Gene name
parE

Comments [?]

Function Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity Reaction=ATP-dependent breakage, passage and rejoining of double-stranded DNA.; EC=5.6.2.2;
Subunit Heterotetramer composed of ParC and ParE.
Similarity Belongs to the type II topoisomerase family. ParE type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0003918; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006265; Biological process: DNA topological change.

Cross-references [?]

PROSITE PS00177; TOPOISOMERASE_II; 1;
PS50880; TOPRIM; 1; trigger=PRU00995;
Pfam PF00204; DNA_gyraseB; 1;
PF00986; DNA_gyraseB_C; 1;
PF02518; HATPase_c; 1;
PF01751; Toprim; 1;
PRINTS PR00418; TPI2FAMILY; 1;
TIGRFAMs TIGR01058; parE_Gpos; 1;

Features [?]

From: PARE_STRPN (Q59961)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     118     124       ATP     G-L-H-G-V-G-[AS]  
BINDING (Optional)     11     11       ATP     Y  
BINDING (Optional)     51     51       ATP     N  
BINDING (Optional)     78     78       ATP     D  
BINDING (Optional)     344     344       ATP     K  
SITE (Optional)     461     461       Interaction with DNA     N  
SITE (Optional)     513     513       Interaction with DNA     H  
SITE (Optional)     629     629       Interaction with DNA     R  

Additional information [?]

Size range 615-710 amino acids
Related rules None
Fusion None
Comments See MF_00938 for ParE type 1 subfamily.