HAMAP rule MF_00941

General rule information [?]

Accession	MF_00941
Dates	7-FEB-2013 (Created) 19-NOV-2022 (Last updated, Version 8)

Name

GDPMH_gmm

Scope

Bacteria; Enterobacteriaceae

Template

P32056 (GMM_ECOLI)

Triggered by

HAMAP; MF_00941 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GMM

Protein name

RecName:		Full=GDP-mannose mannosyl hydrolase;
		Short=GDPMH;
		EC 3.6.1.-;

Gene name

gmm

Comments [?]

Function	Hydrolyzes GDP-mannose.
Catalytic activity	RHEA:28102: GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)

case <FTGroup:1>

Cofactor

Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.

end case

Subunit	Homodimer.
Similarity	Belongs to the Nudix hydrolase family.

Keywords [?]

Hydrolase

case <FTGroup:1>

Magnesium
Metal-binding

end case

Gene Ontology [?]

GO:0008727; Molecular function: GDP-mannose mannosyl hydrolase activity.

case <FTGroup:1>

GO:0000287; Molecular function: magnesium ion binding.

end case

Cross-references [?]

PROSITE	PS51462; NUDIX; 1; trigger=PRU00794;
	PS00893; NUDIX_BOX; 1;
Pfam	PF00293; NUDIX; 1;
PIRSF	PIRSF037599; GDPMH; 1;

Features [?]

From: GMM_ECOLI (P32056)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 2 3 /ligand="substrate F-L

BINDING 49 49 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 G 1

BINDING 69 69 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E 1

BINDING 122 122 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 Q 1

BINDING (Optional) 8 8 /ligand="substrate F

BINDING (Optional) 36 36 /ligand="substrate R

Additional information [?]

Size range	130-184 amino acids
Related rules	None
Fusion	None

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