 |
|
Annotation rule MF_00942 |
General rule information
[?]
Accession |
MF_00942 |
Dates |
13-FEB-2013 (Created) 19-NOV-2019 (Last updated, Version 9) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=Endonuclease III;
|
|
EC 4.2.99.18;
|
AltName:
|
Full=DNA-(apurinic or apyrimidinic site) lyase;
|
|
Function |
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. |
Catalytic activity |
Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.; EC=4.2.99.18; |
Cofactor |
[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. |
Similarity |
Belongs to the Nth/MutY family. |
case <FTGroup:1>
end case
GO:0019104; Molecular function: DNA N-glycosylase activity.
GO:0003906; Molecular function: DNA-(apurinic or apyrimidinic site) endonuclease activity.
GO:0003677; Molecular function: DNA binding.
case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
end case
From: END3_ECOLI (P0AB83) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
METAL
|
|
187
|
|
187
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
1
|
METAL
|
|
194
|
|
194
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
1
|
METAL
|
|
197
|
|
197
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
1
|
METAL
|
|
203
|
|
203
|
|
Iron-sulfur (4Fe-4S)
|
|
|
|
C
|
|
1
|
Additional information
[?]
Size range |
177-390 amino acids |
Related rules |
None |
Fusion |
None |