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HAMAP rule MF_00955

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General rule information [?]

Accession MF_00955
Dates 11-APR-2013 (Created)
1-JUN-2023 (Last updated, Version 12)
Name GDP_Man_dehydratase
Scope(s) Bacteria
Template(s) P0AC88 (GM4D_ECOLI); Q51366 (GM4D_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_00955 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GM4D
Protein name RecName: Full=GDP-mannose 4,6-dehydratase;
AltName: Full=GDP-D-mannose dehydratase;
Gene name Name=gmd;

Comments [?]

FUNCTIONCatalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
CATALYTIC ACTIVITY Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O; Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527, ChEBI:CHEBI:57964; EC=;
COFACTOR Name=NADP(+); Xref=ChEBI:CHEBI:58349;
SIMILARITYBelongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008446; Molecular function:GDP-mannose 4,6-dehydratase activity
GO:0070401; Molecular function:NADP+ binding

Cross-references [?]

Pfam PF01370; Epimerase; 1;
NCBIfam TIGR01472; gmd; 1;

Features [?]

From: GMD2_ARATH (P0AC88)
Key From To Description Tag Condition FTGroup
BINDING 35 40 /ligand="NADP(+)"
BINDING 91 92 /ligand="NADP(+)"
BINDING 113 117 /ligand="NADP(+)"
ACT_SITE 162 162 [TS]
ACT_SITE 164 164 /note="Nucleophile" E
ACT_SITE 185 185 /note="Nucleophile" Y
BINDING 128 128 /ligand="NADP(+)"
BINDING 189 189 /ligand="NADP(+)"
BINDING 215 215 /ligand="NADP(+)"
BINDING 220 220 /ligand="NADP(+)"

Additional information [?]

Size range 300-430 amino acids
Related rules None
Fusion Nter: None Cter: None

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