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Annotation rule MF_00955
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General rule information [?]

Accession MF_00955
Dates 11-APR-2013 (Created)
27-OCT-2018 (Last updated, Version 8)
Name GDP_Man_dehydratase
Scope
Bacteria
Archaea
Templates P0AC88 (GM4D_ECOLI); Q51366 (GM4D_PSEAE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GM4D
Protein name
RecName: Full=GDP-mannose 4,6-dehydratase;
EC=4.2.1.47;
AltName: Full=GDP-D-mannose dehydratase;
Gene name
gmd

Comments [?]

Function Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
Catalytic activity Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O; Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527, ChEBI:CHEBI:57964; EC=4.2.1.47;.
Cofactor NADP(+)
Similarity Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

Keywords [?]

Lyase
NADP

Gene Ontology [?]

GO:0008446; Molecular function: GDP-mannose 4,6-dehydratase activity.
GO:0070401; Molecular function: NADP+ binding.

Cross-references [?]

Pfam PF01370; Epimerase; 1;
TIGRFAMs TIGR01472; gmd; 1;

Features [?]

From: GMD2_ARATH (P0AC88)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     35     40       NADP     G-x-x-G-Q-D  
NP_BIND (Optional)     91     92       NADP     D-[LMIV]  
NP_BIND (Optional)     113     117       NADP     L-x-[AG]-x-[ST]  
ACT_SITE     162     162             [TS]  
ACT_SITE     164     164       Nucleophile     E  
ACT_SITE     185     185       Nucleophile     Y  
BINDING (Optional)     128     128       NADP     Y  
BINDING (Optional)     189     189       NADP     K  
BINDING (Optional)     215     215       NADP     H  
BINDING (Optional)     220     220       NADP     R  

Additional information [?]

Size range 300-430 amino acids
Related rules None
Fusion None


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