HAMAP rule MF_00956
General rule information
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Accession | MF_00956 |
Dates | 12-APR-2013 (Created) 19-NOV-2022 (Last updated, Version 9) |
Name | GDP_fucose_synth |
Scope | Bacteria
Archaea |
Template | P32055 (FCL_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. |
Catalytic activity | RHEA:18885: GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
EC 1.1.1.271 |
Pathway | Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. |
Similarity | Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. |
Keywords
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Gene Ontology
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GO:0050577; Molecular function: GDP-L-fucose synthase activity.
GO:0070401; Molecular function: NADP+ binding.
GO:0042351; Biological process: 'de novo' GDP-L-fucose biosynthetic process.
GO:0070401; Molecular function: NADP+ binding.
GO:0042351; Biological process: 'de novo' GDP-L-fucose biosynthetic process.
Cross-references
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Pfam | PF01370; Epimerase; 1; |
Features
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From: FCL_ECOLI (P32055) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 10 | 16 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | G-x-x-G-x-x-G | ||||||||
BINDING (Optional) | 105 | 108 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [MILV]-[GA]-[ST]-[ST] | ||||||||
BINDING (Optional) | 163 | 166 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | P-x-N-[IVL] | ||||||||
ACT_SITE | 136 | 136 | Proton donor/acceptor | [YF] | ||||||||
BINDING (Optional) | 140 | 140 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | K | ||||||||
BINDING (Optional) | 179 | 179 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | H | ||||||||
BINDING (Optional) | 187 | 187 | /ligand="substrate | [RK] | ||||||||
BINDING (Optional) | 202 | 202 | /ligand="substrate | W | ||||||||
BINDING (Optional) | 209 | 209 | /ligand="substrate | R | ||||||||
BINDING (Optional) | 278 | 278 | /ligand="substrate | [DE] | ||||||||
SITE (Optional) | 107 | 107 | Important for catalytic activity | [ST] | ||||||||
SITE (Optional) | 109 | 109 | Important for catalytic activity | C |
Additional information
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Size range | 280-440 amino acids |
Related rules | None |
Fusion | None |