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HAMAP rule MF_00956

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General rule information [?]

Accession MF_00956
Dates 12-APR-2013 (Created)
19-NOV-2022 (Last updated, Version 9)
Name GDP_fucose_synth
Scope
Bacteria
Archaea
Template P32055 (FCL_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FCL
Protein name
RecName: Full=GDP-L-fucose synthase;
EC 1.1.1.271;
AltName: Full=GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase;
Gene name
fcl

Comments [?]

Function Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Catalytic activity RHEA:18885: GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH
EC 1.1.1.271
Pathway Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
Similarity Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.

Keywords [?]

Isomerase
Multifunctional enzyme
NADP
Oxidoreductase

Gene Ontology [?]

GO:0050577; Molecular function: GDP-L-fucose synthase activity.
GO:0070401; Molecular function: NADP+ binding.
GO:0042351; Biological process: 'de novo' GDP-L-fucose biosynthetic process.

Cross-references [?]

Pfam PF01370; Epimerase; 1;

Features [?]

From: FCL_ECOLI (P32055)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     10     16       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     G-x-x-G-x-x-G  
BINDING (Optional)     105     108       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     [MILV]-[GA]-[ST]-[ST]  
BINDING (Optional)     163     166       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     P-x-N-[IVL]  
ACT_SITE     136     136       Proton donor/acceptor     [YF]  
BINDING (Optional)     140     140       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     K  
BINDING (Optional)     179     179       /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349     H  
BINDING (Optional)     187     187       /ligand="substrate     [RK]  
BINDING (Optional)     202     202       /ligand="substrate     W  
BINDING (Optional)     209     209       /ligand="substrate     R  
BINDING (Optional)     278     278       /ligand="substrate     [DE]  
SITE (Optional)     107     107       Important for catalytic activity     [ST]  
SITE (Optional)     109     109       Important for catalytic activity     C  

Additional information [?]

Size range 280-440 amino acids
Related rules None
Fusion None


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