HAMAP rule MF_00960

General rule information [?]

Accession	MF_00960
Dates	14-MAY-2013 (Created) 1-JUN-2023 (Last updated, Version 9)

Name	ADH_synthase

Scope

Bacteria; Aquificales

Bacteria; Deltaproteobacteria

Archaea

Templates

Q57843 (ADHS_METJA); Q6LZE3 (ADHS_METMP): [Recover all]

Triggered by

HAMAP; MF_00960 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ADHS

Protein name

RecName:		Full=2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
		Short=ADH synthase;
		Short=ADHS;
		Short=ADTH synthase;
		EC 2.2.1.10;

Gene name

aroA'

Comments [?]

Function	Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
Catalytic activity	RHEA:25952: 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate EC 2.2.1.10
Subunit	Homodecamer.
Similarity	Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.

Keywords [?]

Amino-acid biosynthesis
Aromatic amino acid biosynthesis
Schiff base
Transferase

Gene Ontology [?]

GO:0016744; Molecular function: transketolase or transaldolase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam	PF01791; DeoC; 1;
NCBIfam	TIGR01949; AroFGH_arch; 1;

Features [?]

From: ADHS_METJA (Q57843)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 33 37 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 D-H-G-[VIM]-[ST]

BINDING (Optional) 153 155 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 Y-x-R

BINDING (Optional) 209 210 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 G-G

BINDING (Optional) 237 238 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 G-R

ACT_SITE 33 33 Proton acceptor D

ACT_SITE 153 153 Proton donor Y

ACT_SITE 184 184 Schiff-base intermediate with substrate K

Additional information [?]

Size range	243-294 amino acids
Related rules	None
Fusion	None

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