HAMAP rule MF_00960
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00960 |
| Accession | MF_00960 |
| Dates | 14-MAY-2013 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | ADH_synthase |
| Scope(s) |
Bacteria Aquificales Deltaproteobacteria Archaea |
| Template(s) | Q57843 (ADHS_METJA); Q6LZE3 (ADHS_METMP); [ Recover all ] |
| Triggered by |
HAMAP; MF_00960 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ADHS |
| Protein name | RecName: Full=2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Short=ADH synthase; Short=ADHS; Short=ADTH synthase; EC=2.2.1.10; |
| Gene name | Name=aroA'; |
Comments
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| FUNCTION | Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. |
| CATALYTIC ACTIVITY | Reaction=1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4- semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D- lyxo-hept-6-ulosonate; Xref=Rhea:RHEA:25952, ChEBI:CHEBI:58859, ChEBI:CHEBI:58860, ChEBI:CHEBI:58861, ChEBI:CHEBI:537519; EC=2.2.1.10; |
| SUBUNIT | Homodecamer. |
| SIMILARITY | Belongs to the DeoC/FbaB aldolase family. ADHS subfamily. |
Keywords
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Gene Ontology
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| GO:0016744; Molecular function:transketolase or transaldolase activity |
| GO:0009073; Biological process:aromatic amino acid family biosynthetic process |
Cross-references
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Features
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| From: ADHS_METJA (Q57843) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 33 | 37 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861" |
D-H-G-[VIM]-[ST] | ||||||||
| BINDING | 153 | 155 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861" |
Y-x-R | ||||||||
| BINDING | 209 | 210 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861" |
G-G | ||||||||
| BINDING | 237 | 238 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861" |
G-R | ||||||||
| ACT_SITE | 33 | 33 | /note="Proton acceptor" | D | ||||||||
| ACT_SITE | 153 | 153 | /note="Proton donor" | Y | ||||||||
| ACT_SITE | 184 | 184 | /note="Schiff-base intermediate with substrate" | K | ||||||||
Additional information
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| Size range | 243-294 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |