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HAMAP rule MF_00960

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General rule information [?]

Accession MF_00960
Dates 14-MAY-2013 (Created)
1-JUN-2023 (Last updated, Version 9)
Name ADH_synthase
Bacteria; Aquificales
Bacteria; Deltaproteobacteria
Templates Q57843 (ADHS_METJA); Q6LZE3 (ADHS_METMP): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
Short=ADH synthase;
Short=ADTH synthase;
Gene name

Comments [?]

Function Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
Catalytic activity RHEA:25952: 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate
Subunit Homodecamer.
Similarity Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016744; Molecular function: transketolase or transaldolase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

Cross-references [?]

Pfam PF01791; DeoC; 1;
NCBIfam TIGR01949; AroFGH_arch; 1;

Features [?]

From: ADHS_METJA (Q57843)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     33     37       /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861     D-H-G-[VIM]-[ST]  
BINDING (Optional)     153     155       /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861     Y-x-R  
BINDING (Optional)     209     210       /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861     G-G  
BINDING (Optional)     237     238       /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861     G-R  
ACT_SITE     33     33       Proton acceptor     D  
ACT_SITE     153     153       Proton donor     Y  
ACT_SITE     184     184       Schiff-base intermediate with substrate     K  

Additional information [?]

Size range 243-294 amino acids
Related rules None
Fusion None