HAMAP logo

HAMAP rule MF_00960

Send feedback

General rule information [?]

Accession MF_00960
Dates 14-MAY-2013 (Created)
1-JUN-2023 (Last updated, Version 9)
Name ADH_synthase
Scope(s) Bacteria
Template(s) Q57843 (ADHS_METJA); Q6LZE3 (ADHS_METMP); [ Recover all ]
Triggered by HAMAP; MF_00960 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ADHS
Protein name RecName: Full=2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
                 Short=ADH synthase;
                 Short=ADTH synthase;
Gene name Name=aroA';

Comments [?]

FUNCTIONCatalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
CATALYTIC ACTIVITY Reaction=1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4- semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D- lyxo-hept-6-ulosonate; Xref=Rhea:RHEA:25952, ChEBI:CHEBI:58859, ChEBI:CHEBI:58860, ChEBI:CHEBI:58861, ChEBI:CHEBI:537519; EC=;
SIMILARITYBelongs to the DeoC/FbaB aldolase family. ADHS subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016744; Molecular function:transketolase or transaldolase activity
GO:0009073; Biological process:aromatic amino acid family biosynthetic process

Cross-references [?]

Pfam PF01791; DeoC; 1;
NCBIfam TIGR01949; AroFGH_arch; 1;

Features [?]

From: ADHS_METJA (Q57843)
Key From To Description Tag Condition FTGroup
BINDING 33 37 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
BINDING 153 155 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
BINDING 209 210 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
BINDING 237 238 /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
ACT_SITE 33 33 /note="Proton acceptor" D
ACT_SITE 153 153 /note="Proton donor" Y
ACT_SITE 184 184 /note="Schiff-base intermediate with substrate" K

Additional information [?]

Size range 243-294 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)