HAMAP rule MF_00960
General rule information
[?]
Accession | MF_00960 |
Dates | 14-MAY-2013 (Created) 1-JUN-2023 (Last updated, Version 9) |
Name | ADH_synthase |
Scope | Bacteria; Aquificales
Bacteria; Deltaproteobacteria
Archaea |
Templates | Q57843 (ADHS_METJA); Q6LZE3 (ADHS_METMP): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. |
Catalytic activity | RHEA:25952: 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate
EC 2.2.1.10 |
Subunit | Homodecamer. |
Similarity | Belongs to the DeoC/FbaB aldolase family. ADHS subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0016744; Molecular function: transketolase or transaldolase activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.
Cross-references
[?]
Features
[?]
From: ADHS_METJA (Q57843) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 33 | 37 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 | D-H-G-[VIM]-[ST] | ||||||||
BINDING (Optional) | 153 | 155 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 | Y-x-R | ||||||||
BINDING (Optional) | 209 | 210 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 | G-G | ||||||||
BINDING (Optional) | 237 | 238 | /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate" /ligand_id="ChEBI:CHEBI:58861 | G-R | ||||||||
ACT_SITE | 33 | 33 | Proton acceptor | D | ||||||||
ACT_SITE | 153 | 153 | Proton donor | Y | ||||||||
ACT_SITE | 184 | 184 | Schiff-base intermediate with substrate | K |
Additional information
[?]
Size range | 243-294 amino acids |
Related rules | None |
Fusion | None |