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HAMAP rule MF_00963

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General rule information [?]

Accession MF_00963
Dates 31-MAY-2013 (Created)
1-JUN-2023 (Last updated, Version 21)
Name Sigma70_RpoD_SigA
Scope(s) Bacteria
Template(s) P00579 (RPOD_ECOLI); P0A0J0 (SIGA_STAA8); P77994 (SIGA_THEMA); Q72L95 (SIGA_THET2); Q9EZJ8 (SIGA_THEAQ); [ Recover all ]
Triggered by HAMAP; MF_00963 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Pseudomonadota> or <OC:Spirochaetales>
Identifier RPOD
Protein name RecName: Full=RNA polymerase sigma factor RpoD;
AltName: Full=Sigma-70;
Gene name Name=rpoD;
Identifier SIGA
Protein name RecName: Full=RNA polymerase sigma factor SigA;
Gene name Name=sigA;
end case

Comments [?]

FUNCTIONSigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
SUBUNITInteracts transiently with the RNA polymerase catalytic core.
SIMILARITYBelongs to the sigma-70 factor family. RpoD/SigA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0016987; Molecular function:sigma factor activity
GO:0010468; Biological process:regulation of gene expression
GO:0006352; Biological process:DNA-templated transcription initiation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00715; SIGMA70_1; 1;
PROSITE PS00716; SIGMA70_2; 1;
Pfam PF04546; Sigma70_ner; 0-1;
Pfam PF03979; Sigma70_r1_1; 0-1;
Pfam PF00140; Sigma70_r1_2; 0-1;
Pfam PF04542; Sigma70_r2; 1;
Pfam PF04539; Sigma70_r3; 1;
Pfam PF04545; Sigma70_r4; 1;
NCBIfam TIGR02393; RpoD_Cterm; 1;
NCBIfam TIGR02937; sigma70-ECF; 1;
NCBIfam TIGR02997; Sig70-cyanoRpoD; 0-1;

Features [?]

From: RPOD_ECOLI (P00579)
Key From To Description Tag Condition FTGroup
DNA_BIND 573 592 /note="H-T-H motif"
REGION 379 449 /note="Sigma-70 factor domain-2"
REGION 458 534 /note="Sigma-70 factor domain-3"
REGION 547 600 /note="Sigma-70 factor domain-4"
MOTIF 403 406 /note="Interaction with polymerase core subunit RpoC" D-[LI]-[IVLF]-[QE]

Additional information [?]

Size range 310-900 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments RpoD/SigA is the major sigma factor of most bacteria. Sequences, domains and nomenclature are highly variable. It is called RpoD in E.coli, and SigA in Bacillota and Actinomycetota.

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