HAMAP rule MF_00964
General rule information
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Accession | MF_00964 |
Dates | 5-JUN-2013 (Created)
13-JUL-2020 (Last updated, Version 7) |
Name | DEAD_helicase_DeaD |
Scope(s) |
Bacteria |
Template(s) | P0A9P6 (DEAD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00964 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DEAD |
RecName: Full=ATP-dependent RNA helicase DeaD;<br /> EC=<a href="https://enzyme.expasy.org/EC/3.6.4.13">3.6.4.13</a>;<br /> AltName: Full=Cold-shock DEAD box protein A; | |
Gene name | Name=deaD; Synonyms=csdA; |
Comments
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FUNCTION | DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. |
CATALYTIC ACTIVITY | Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the DEAD box helicase family. DeaD/CsdA subfamily. |
Keywords
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ATP-binding | |
Cytoplasm | |
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
Hydrolase | |
Nucleotide-binding | |
RNA-binding | |
Stress response |
Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0003724; Molecular function:RNA helicase activity |
GO:0003723; Molecular function:RNA binding |
GO:0000027; Biological process:ribosomal large subunit assembly |
GO:0006401; Biological process:RNA catabolic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS00039; DEAD_ATP_HELICASE; 1; |
PROSITE | PS51192; HELICASE_ATP_BIND_1; 1; |
PROSITE | PS51194; HELICASE_CTER; 1; |
PROSITE | PS51195; Q_MOTIF; 1; |
Pfam | PF03880; DbpA; 1; |
Pfam | PF00270; DEAD; 1; |
Pfam | PF12343; DEADboxA; 1; |
Pfam | PF00271; Helicase_C; 1; |
Features
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Additional information
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Size range | 520-862 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |