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HAMAP rule MF_00964

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General rule information [?]

Accession MF_00964
Dates 5-JUN-2013 (Created)
13-JUL-2020 (Last updated, Version 7)
Name DEAD_helicase_DeaD
Scope(s) Bacteria
Template(s) P0A9P6 (DEAD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00964 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DEAD
RecName: Full=ATP-dependent RNA helicase DeaD;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.13">3.6.4.13</a>;<br /> AltName: Full=Cold-shock DEAD box protein A;
Gene name Name=deaD; Synonyms=csdA;

Comments [?]

FUNCTIONDEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.
CATALYTIC ACTIVITY Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the DEAD box helicase family. DeaD/CsdA subfamily.

Keywords [?]

ATP-binding
Cytoplasm
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nucleotide-binding
RNA-binding
Stress response

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0003724; Molecular function:RNA helicase activity
GO:0003723; Molecular function:RNA binding
GO:0000027; Biological process:ribosomal large subunit assembly
GO:0006401; Biological process:RNA catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00039; DEAD_ATP_HELICASE; 1;
PROSITE PS51192; HELICASE_ATP_BIND_1; 1;
PROSITE PS51194; HELICASE_CTER; 1;
PROSITE PS51195; Q_MOTIF; 1;
Pfam PF03880; DbpA; 1;
Pfam PF00270; DEAD; 1;
Pfam PF12343; DEADboxA; 1;
Pfam PF00271; Helicase_C; 1;

Features [?]


Additional information [?]

Size range 520-862 amino acids
Related rules None
Fusion Nter: None Cter: None



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