HAMAP rule MF_00965

General rule information [?]

Accession	MF_00965
Dates	12-JUN-2013 (Created) 3-SEP-2024 (Last updated, Version 6)
Name	DEAD_helicase_DbpA
Scope(s)	Bacteria
Template(s)	P42305 (DBPA_BACSU); P21693 (DBPA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00965 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DBPA
RecName: Full=ATP-dependent RNA helicase DbpA;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.13">3.6.4.13</a>;
Gene name	Name=dbpA;

Comments [?]

FUNCTION	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
CATALYTIC ACTIVITY	Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
SUBCELLULAR LOCATION	Cytoplasm.
DOMAIN	Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
SIMILARITY	Belongs to the DEAD box helicase family. DbpA subfamily.

Keywords [?]

ATP-binding
Cytoplasm
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nucleotide-binding
Ribosome biogenesis
RNA-binding

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0034458; Molecular function:3'-5' RNA helicase activity

GO:0003723; Molecular function:RNA binding

GO:0000027; Biological process:ribosomal large subunit assembly

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: DBPA_BACSU (P42305)

Key

From

Description

Tag

Condition

FTGroup

REGION

404

Cter

/note="Involved in 23S rRNA binding"

Additional information [?]