HAMAP rule MF_00965

Accession	MF_00965
Dates	12-JUN-2013 (Created) 19-NOV-2019 (Last updated, Version 5)

Name	DEAD_helicase_DbpA

Scope

Bacteria

Templates

P42305 (DBPA_BACSU); P21693 (DBPA_ECOLI): [Recover all]

Triggered by

HAMAP; MF_00965 (Get profile general information and statistics)

Identifier

DBPA

Protein name

RecName: Full=ATP-dependent RNA helicase DbpA; EC 3.6.4.13;

Gene name

dbpA

Function	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
Catalytic activity	RHEA:13065: ATP + H2O = ADP + H(+) + phosphate EC 3.6.4.13
Subcellular location	Cytoplasm.
Domain	Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
Similarity	Belongs to the DEAD box helicase family. DbpA subfamily.

ATP-binding
Cytoplasm
Helicase
Hydrolase
Nucleotide-binding
Ribosome biogenesis
RNA-binding

GO:0005524; Molecular function: ATP binding.
GO:0034458; Molecular function: 3'-5' RNA helicase activity.
GO:0003723; Molecular function: RNA binding.
GO:0000027; Biological process: ribosomal large subunit assembly.
GO:0005737; Cellular component: cytoplasm.

PROSITE	PS00039; DEAD_ATP_HELICASE; 1;
	PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541;
	PS51194; HELICASE_CTER; 1; trigger=PRU00542;
	PS51195; Q_MOTIF; 1; trigger=PRU00552;
Pfam	PF03880; DbpA; 1;
	PF00270; DEAD; 1;
	PF00271; Helicase_C; 1;

From: DBPA_BACSU (P42305)

Key

From

To

Description

Tag

Condition

FTGroup

REGION

404

Cter

Involved in 23S rRNA binding

Size range	430-529 amino acids
Related rules	None
Fusion	None

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