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HAMAP rule MF_00965

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General rule information [?]

Accession MF_00965
Dates 12-JUN-2013 (Created)
19-NOV-2019 (Last updated, Version 5)
Name DEAD_helicase_DbpA
Templates P42305 (DBPA_BACSU); P21693 (DBPA_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=ATP-dependent RNA helicase DbpA;
Gene name

Comments [?]

Function DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.
Catalytic activity RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
Subcellular location Cytoplasm.
Domain Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
Similarity Belongs to the DEAD box helicase family. DbpA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0034458; Molecular function: 3'-5' RNA helicase activity.
GO:0003723; Molecular function: RNA binding.
GO:0000027; Biological process: ribosomal large subunit assembly.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541;
PS51194; HELICASE_CTER; 1; trigger=PRU00542;
PS51195; Q_MOTIF; 1; trigger=PRU00552;
Pfam PF03880; DbpA; 1;
PF00270; DEAD; 1;
PF00271; Helicase_C; 1;

Features [?]

From: DBPA_BACSU (P42305)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     404     Cter       Involved in 23S rRNA binding        

Additional information [?]

Size range 430-529 amino acids
Related rules None
Fusion None