HAMAP rule MF_00966
General rule information
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| Accession | MF_00966 |
| Dates | 17-JUN-2013 (Created) 1-JUN-2023 (Last updated, Version 9) |
| Name | G6PD |
| Scope | Bacteria |
| Templates | P11411 (G6PD_LEUME); P0AC53 (G6PD_ECOLI); O68282 (G6PD_PSEAE); Q5FUK8 (G6PD_GLUOX): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. |
| Catalytic activity | RHEA:15841: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
EC 1.1.1.49 |
| Pathway | Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. |
| Similarity | Belongs to the glucose-6-phosphate dehydrogenase family. |
Keywords
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Gene Ontology
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GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity.
GO:0050661; Molecular function: NADP binding.
GO:0006098; Biological process: pentose-phosphate shunt.
GO:0050661; Molecular function: NADP binding.
GO:0006098; Biological process: pentose-phosphate shunt.
Cross-references
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| PROSITE | PS00069; G6P_DEHYDROGENASE; 1; |
| Pfam | PF02781; G6PD_C; 1; |
| PF00479; G6PD_N; 1; | |
| PRINTS | PR00079; G6PDHDRGNASE; 1; |
| NCBIfam | TIGR00871; zwf; 1; |
| PIRSF | PIRSF000110; G6PD; 1; |
Features
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| From: G6PD_LEUME (P11411) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 13 | 20 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | G-[GAS]-[TS]-G-[DEN]-L-[AST]-[KR] | ||||||||
| BINDING (Optional) | 86 | 87 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [DE]-[VLIF] | ||||||||
| ACT_SITE | 241 | 241 | Proton acceptor | H | ||||||||
| BINDING (Optional) | 47 | 47 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | [RAS] | ||||||||
| BINDING (Optional) | 149 | 149 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349 | K | ||||||||
| BINDING (Optional) | 179 | 179 | /ligand="substrate | H | ||||||||
| BINDING (Optional) | 183 | 183 | /ligand="substrate | K | ||||||||
| BINDING (Optional) | 217 | 217 | /ligand="substrate | E | ||||||||
| BINDING (Optional) | 236 | 236 | /ligand="substrate | D | ||||||||
| BINDING (Optional) | 339 | 339 | /ligand="substrate | K | ||||||||
| BINDING (Optional) | 344 | 344 | /ligand="substrate | K | ||||||||
Additional information
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| Size range | 425-612 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Two members of the family (G6PD_LEUME and G6PD_PSEAE) can use either NADP(+) or NAD(+) and have a different EC number (EC 1.1.1.363). These are probably exceptions. |