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HAMAP rule MF_00966
General rule information
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| Accession | MF_00966 |
| Dates | 17-JUN-2013 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | G6PD |
| Scope(s) |
Bacteria |
| Template(s) | P11411 (G6PD_LEUME); P0AC53 (G6PD_ECOLI); O68282 (G6PD_PSEAE); Q5FUK8 (G6PD_GLUOX); [ Recover all ] |
| Triggered by |
HAMAP; MF_00966 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | G6PD |
| Protein name | RecName: Full=Glucose-6-phosphate 1-dehydrogenase; Short=G6PD; EC=1.1.1.49; |
| Gene name | Name=zwf; |
Comments
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| FUNCTION | Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. |
| CATALYTIC ACTIVITY | Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=1.1.1.49; |
| PATHWAY | Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. |
| SIMILARITY | Belongs to the glucose-6-phosphate dehydrogenase family. |
Keywords
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Gene Ontology
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| GO:0004345; Molecular function:glucose-6-phosphate dehydrogenase activity |
| GO:0050661; Molecular function:NADP binding |
| GO:0006098; Biological process:pentose-phosphate shunt |
Cross-references
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| PROSITE | PS00069; G6P_DEHYDROGENASE; 1; |
| Pfam | PF02781; G6PD_C; 1; |
| Pfam | PF00479; G6PD_N; 1; |
| PRINTS | PR00079; G6PDHDRGNASE; 1; |
| NCBIfam | TIGR00871; zwf; 1; |
| PIRSF | PIRSF000110; G6PD; 1; |
Features
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| From: G6PD_LEUME (P11411) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 13 | 20 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
G-[GAS]-[TS]-G-[DEN]-L-[AST]-[KR] | ||||||||
| BINDING | 86 | 87 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[DE]-[VLIF] | ||||||||
| ACT_SITE | 241 | 241 | /note="Proton acceptor" | H | ||||||||
| BINDING | 47 | 47 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
[RAS] | ||||||||
| BINDING | 149 | 149 | /ligand="NADP(+)" /ligand_id="ChEBI:CHEBI:58349" |
K | ||||||||
| BINDING | 179 | 179 | /ligand="substrate" | H | ||||||||
| BINDING | 183 | 183 | /ligand="substrate" | K | ||||||||
| BINDING | 217 | 217 | /ligand="substrate" | E | ||||||||
| BINDING | 236 | 236 | /ligand="substrate" | D | ||||||||
| BINDING | 339 | 339 | /ligand="substrate" | K | ||||||||
| BINDING | 344 | 344 | /ligand="substrate" | K | ||||||||
Additional information
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| Size range | 425-612 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Two members of the family (G6PD_LEUME and G6PD_PSEAE) can use either NADP(+) or NAD(+) and have a different EC number (EC 1.1.1.363). These are probably exceptions. |