HAMAP logo

HAMAP rule MF_00966

Send feedback

General rule information [?]

Accession MF_00966
Dates 17-JUN-2013 (Created)
1-JUN-2023 (Last updated, Version 9)
Name G6PD
Scope(s) Bacteria
Template(s) P11411 (G6PD_LEUME); P0AC53 (G6PD_ECOLI); O68282 (G6PD_PSEAE); Q5FUK8 (G6PD_GLUOX); [ Recover all ]
Triggered by HAMAP; MF_00966 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier G6PD
Protein name RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
Gene name Name=zwf;

Comments [?]

FUNCTIONCatalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
CATALYTIC ACTIVITY Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5- lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=;
PATHWAYCarbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
SIMILARITYBelongs to the glucose-6-phosphate dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0004345; Molecular function:glucose-6-phosphate dehydrogenase activity
GO:0050661; Molecular function:NADP binding
GO:0006098; Biological process:pentose-phosphate shunt

Cross-references [?]

Pfam PF02781; G6PD_C; 1;
Pfam PF00479; G6PD_N; 1;
NCBIfam TIGR00871; zwf; 1;
PIRSF PIRSF000110; G6PD; 1;

Features [?]

From: G6PD_LEUME (P11411)
Key From To Description Tag Condition FTGroup
BINDING 13 20 /ligand="NADP(+)"
BINDING 86 87 /ligand="NADP(+)"
ACT_SITE 241 241 /note="Proton acceptor" H
BINDING 47 47 /ligand="NADP(+)"
BINDING 149 149 /ligand="NADP(+)"
BINDING 179 179 /ligand="substrate" H
BINDING 183 183 /ligand="substrate" K
BINDING 217 217 /ligand="substrate" E
BINDING 236 236 /ligand="substrate" D
BINDING 339 339 /ligand="substrate" K
BINDING 344 344 /ligand="substrate" K

Additional information [?]

Size range 425-612 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Two members of the family (G6PD_LEUME and G6PD_PSEAE) can use either NADP(+) or NAD(+) and have a different EC number (EC These are probably exceptions.

View rule in raw text format (no links)