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Annotation rule MF_00966
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General rule information [?]

Accession MF_00966
Dates 17-JUN-2013 (Created)
27-OCT-2018 (Last updated, Version 5)
Name G6PD
Scope
Bacteria
Templates P11411 (G6PD_LEUME); P0AC53 (G6PD_ECOLI); O68282 (G6PD_PSEAE); Q5FUK8 (G6PD_GLUOX): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
G6PD
Protein name
RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
Short=G6PD;
EC=1.1.1.49;
Gene name
zwf

Comments [?]

Function Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono- 1,5-lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, ChEBI:CHEBI:61548; EC=1.1.1.49;.
Pathway Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Similarity Belongs to the glucose-6-phosphate dehydrogenase family.

Keywords [?]


Gene Ontology [?]

GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity.
GO:0050661; Molecular function: NADP binding.
GO:0006098; Biological process: pentose-phosphate shunt.

Cross-references [?]

PROSITE PS00069; G6P_DEHYDROGENASE; 1;
Pfam PF02781; G6PD_C; 1;
PF00479; G6PD_N; 1;
PRINTS PR00079; G6PDHDRGNASE; 1;
TIGRFAMs TIGR00871; zwf; 1;
PIRSF PIRSF000110; G6PD; 1;

Features [?]

From: G6PD_LEUME (P11411)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     13     20       NADP     G-[GAS]-[TS]-G-[DEN]-L-[AST]-[KR]  
NP_BIND (Optional)     86     87       NADP     [DE]-[VLIF]  
ACT_SITE     241     241       Proton acceptor     H  
BINDING (Optional)     47     47       NADP     [RAS]  
BINDING (Optional)     149     149       NADP     K  
BINDING (Optional)     179     179       Substrate     H  
BINDING (Optional)     183     183       Substrate     K  
BINDING (Optional)     217     217       Substrate     E  
BINDING (Optional)     236     236       Substrate     D  
BINDING (Optional)     339     339       Substrate     K  
BINDING (Optional)     344     344       Substrate     K  

Additional information [?]

Size range 425-612 amino acids
Related rules None
Fusion None
Comments Two members of the family (G6PD_LEUME and G6PD_PSEAE) can use either NADP(+) or NAD(+) and have a different EC number (EC 1.1.1.363). These are probably exceptions.