HAMAP rule MF_00969

Accession	MF_00969
Dates	10-JUL-2013 (Created) 1-JUN-2023 (Last updated, Version 6)

Name

TRCF

Scope

Bacteria

Template

P30958 (MFD_ECOLI)

Triggered by

HAMAP; MF_00969 (Get profile general information and statistics)

Identifier

MFD

Protein name

RecName: Full=Transcription-repair-coupling factor; Short=TRCF; EC 3.6.4.-;

Gene name

mfd

Function	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular location	Cytoplasm.
Similarity	In the N-terminal section; belongs to the UvrB family.
	In the C-terminal section; belongs to the helicase family. RecG subfamily.

ATP-binding
Cytoplasm
DNA damage
DNA repair
DNA-binding
Hydrolase
Nucleotide-binding

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0000716; Biological process: transcription-coupled nucleotide-excision repair, DNA damage recognition.
GO:0005737; Cellular component: cytoplasm.

PROSITE	PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541;
	PS51194; HELICASE_CTER; 1; trigger=PRU00542;
Pfam	PF02559; CarD_CdnL_TRCF; 1;
	PF00270; DEAD; 1;
	PF00271; Helicase_C; 1;
	PF03461; TRCF; 1;
NCBIfam	TIGR00580; mfd; 1;

Size range	700-1450 amino acids
Related rules	None
Fusion	None

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