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HAMAP rule MF_00969

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General rule information [?]

Accession MF_00969
Dates 10-JUL-2013 (Created)
1-JUN-2023 (Last updated, Version 6)
Template P30958 (MFD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Transcription-repair-coupling factor;
EC 3.6.4.-;
Gene name

Comments [?]

Function Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
Subcellular location Cytoplasm.
Similarity In the N-terminal section; belongs to the UvrB family.
In the C-terminal section; belongs to the helicase family. RecG subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0000716; Biological process: transcription-coupled nucleotide-excision repair, DNA damage recognition.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541;
PS51194; HELICASE_CTER; 1; trigger=PRU00542;
Pfam PF02559; CarD_CdnL_TRCF; 1;
PF00270; DEAD; 1;
PF00271; Helicase_C; 1;
PF03461; TRCF; 1;
NCBIfam TIGR00580; mfd; 1;

Additional information [?]

Size range 700-1450 amino acids
Related rules None
Fusion None