HAMAP rule MF_00969
General rule information
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Accession | MF_00969 |
Dates | 10-JUL-2013 (Created)
1-JUN-2023 (Last updated, Version 6) |
Name | TRCF |
Scope(s) |
Bacteria |
Template(s) | P30958 (MFD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00969 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MFD |
Protein name | RecName: Full=Transcription-repair-coupling factor; Short=TRCF; EC=3.6.4.-; |
Gene name | Name=mfd; |
Comments
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FUNCTION | Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | In the N-terminal section; belongs to the UvrB family. |
SIMILARITY | In the C-terminal section; belongs to the helicase family. RecG subfamily. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0003677; Molecular function:DNA binding |
GO:0006355; Biological process:regulation of DNA-templated transcription |
GO:0000716; Biological process:transcription-coupled nucleotide-excision repair, DNA damage recognition |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS51192; HELICASE_ATP_BIND_1; 1; |
PROSITE | PS51194; HELICASE_CTER; 1; |
Pfam | PF02559; CarD_CdnL_TRCF; 1; |
Pfam | PF00270; DEAD; 1; |
Pfam | PF00271; Helicase_C; 1; |
Pfam | PF03461; TRCF; 1; |
NCBIfam | TIGR00580; mfd; 1; |
Features
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Additional information
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Size range | 700-1450 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |