HAMAP rule MF_00979
General rule information
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| Accession | MF_00979 |
| Dates | 12-DEC-2013 (Created) 29-SEP-2022 (Last updated, Version 7) |
| Name | RcsC |
| Scope | Bacteria; Enterobacterales |
| Template | P0DMC5 (RCSC_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. |
| Catalytic activity | Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.; EC=2.7.13.3; |
| Subunit | Interacts with RcsD. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
| Ptm | Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain. |
| Similarity | Belongs to the RcsC family. |
Keywords
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ATP-binding
Cell inner membrane
Cell membrane
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Transferase
Transmembrane
Transmembrane helix
Two-component regulatory system
Cell inner membrane
Cell membrane
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Transferase
Transmembrane
Transmembrane helix
Two-component regulatory system
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0000155; Molecular function: phosphorelay sensor kinase activity.
GO:0046777; Biological process: protein autophosphorylation.
GO:0000160; Biological process: phosphorelay signal transduction system.
GO:0005886; Cellular component: plasma membrane.
GO:0000155; Molecular function: phosphorelay sensor kinase activity.
GO:0046777; Biological process: protein autophosphorylation.
GO:0000160; Biological process: phosphorelay signal transduction system.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| PROSITE | PS51426; ABL; 1; trigger=PRU00751; |
| PS50109; HIS_KIN; 1; trigger=PRU00107; | |
| PS50112; PAS; 1; trigger=PRU00140; | |
| PS50110; RESPONSE_REGULATORY; 1; trigger=PRU00169; | |
| Pfam | PF02518; HATPase_c; 1; |
| PF00512; HisKA; 1; | |
| PF09456; RcsC; 1; | |
| PF00072; Response_reg; 1; | |
| PRINTS | PR00344; BCTRLSENSOR; 1; |
Computed features
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| General | Transmembrane; -; 2; trigger=yes; |
Features
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| From: RCSC_ECOLI (P0DMC5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 479 | 479 | Phosphohistidine; by autocatalysis | H | ||||||||
| MOD_RES | 875 | 875 | 4-aspartylphosphate | D | ||||||||
Additional information
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| Size range | 900-1000 amino acids |
| Related rules | None |
| Fusion | None |