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Annotation rule MF_00979 |
Accession | MF_00979 |
Dates | 12-DEC-2013 (Created) 19-NOV-2019 (Last updated, Version 6) |
Name | RcsC |
Scope | Bacteria; Enterobacterales |
Template | P0DMC5 (RCSC_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. |
Catalytic activity | Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.; EC=2.7.13.3; |
Subunit | Interacts with RcsD. |
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
Ptm | Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain. |
Similarity | Belongs to the RcsC family. |
PROSITE | PS51426; ABL; 1; trigger=PRU00751; |
PS50109; HIS_KIN; 1; trigger=PRU00107; | |
PS50112; PAS; 1; trigger=PRU00140; | |
PS50110; RESPONSE_REGULATORY; 1; trigger=PRU00169; | |
Pfam | PF02518; HATPase_c; 1; |
PF00512; HisKA; 1; | |
PF09456; RcsC; 1; | |
PF00072; Response_reg; 1; | |
PRINTS | PR00344; BCTRLSENSOR; 1; |
General | Transmembrane; -; 2; trigger=yes; |
From: RCSC_ECOLI (P0DMC5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 479 | 479 | Phosphohistidine; by autocatalysis | H | ||||||||
MOD_RES | 875 | 875 | 4-aspartylphosphate | D |
Size range | 900-1000 amino acids |
Related rules | None |
Fusion | None |