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Annotation rule MF_00979
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General rule information [?]

Accession MF_00979
Dates 12-DEC-2013 (Created)
19-NOV-2019 (Last updated, Version 6)
Name RcsC
Scope
Bacteria; Enterobacterales
Template P0DMC5 (RCSC_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RCSC
Protein name
RecName: Full=Sensor histidine kinase RcsC;
EC 2.7.13.3;
Gene name
rcsC

Comments [?]

Function Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
Catalytic activity Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.; EC=2.7.13.3;
Subunit Interacts with RcsD.
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Ptm Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain.
Similarity Belongs to the RcsC family.

Keywords [?]

ATP-binding
Cell inner membrane
Cell membrane
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Transferase
Transmembrane
Transmembrane helix
Two-component regulatory system

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000155; Molecular function: phosphorelay sensor kinase activity.
GO:0046777; Biological process: protein autophosphorylation.
GO:0000160; Biological process: phosphorelay signal transduction system.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

PROSITE PS51426; ABL; 1; trigger=PRU00751;
PS50109; HIS_KIN; 1; trigger=PRU00107;
PS50112; PAS; 1; trigger=PRU00140;
PS50110; RESPONSE_REGULATORY; 1; trigger=PRU00169;
Pfam PF02518; HATPase_c; 1;
PF00512; HisKA; 1;
PF09456; RcsC; 1;
PF00072; Response_reg; 1;
PRINTS PR00344; BCTRLSENSOR; 1;

Computed features [?]

General Transmembrane; -; 2; trigger=yes;

Features [?]

From: RCSC_ECOLI (P0DMC5)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     479     479       Phosphohistidine; by autocatalysis     H  
MOD_RES     875     875       4-aspartylphosphate     D  

Additional information [?]

Size range 900-1000 amino acids
Related rules None
Fusion None


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